期刊
CHEMICAL COMMUNICATIONS
卷 51, 期 80, 页码 14826-14831出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc04536c
关键词
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资金
- ANR Malz [ANR-10-MALZ-0004]
- France Alzheimer
- Labex IRON [ANR-11-LABX-0018-01]
- Region Centre
- Agence Nationale de la Recherche (ANR) [ANR-10-MALZ-0004] Funding Source: Agence Nationale de la Recherche (ANR)
Positron emission tomography (PET) molecular imaging of brain targets is a powerful tool to diagnose, follow up, and develop treatments and personalized medicine for a number of acute and chronic brain disorders. The availability of beta+ emitter tracers labelled with [C-11] or [F-18] having optimal characteristics of affinity and selectivity for alpha-7 nicotinic receptors (alpha 7R) has received considerable attention, due to the major implication of these receptors in brain functions. The aim of this review is to identify the interest and need for the in vivo exploration of alpha 7R by PET molecular imaging, which tools are currently available for this and how to progress.
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