A vision for closing the evidence-practice gap in the management of low-grade prostate cancer

Article Urology & Nephrology

Use of Monitoring Tests Among Patients With Localized Prostate Cancer Managed With Observation

Michael S. Leapman et al.

Summary: It is unclear whether compliance with recommended monitoring tests has changed over time for patients with localized prostate cancer undergoing observation. A retrospective cohort study of Medicare beneficiaries diagnosed with low- or intermediate-risk prostate cancer in 2004-2016 was conducted to examine rates of PSA testing, prostate biopsy, and prostate MRI. The study found that usage of recommended monitoring tests remains low among patients managed with observation and that rates of PSA testing and biopsy have increased over time. Various factors including age, clinical risk, race/ethnicity, census tract poverty, and region were associated with testing rates.

JOURNAL OF UROLOGY (2023)

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Article Medicine, General & Internal

Time Trends and Variation in the Use of Active Surveillance for Management of Low-risk Prostate Cancer in the US

Matthew R. Cooperberg et al.

Summary: This study analyzed the use of active surveillance for low-risk prostate cancer patients using the American Urological Association Quality Registry. The findings showed an increase in active surveillance rates from 26.5% in 2014 to 59.6% in 2021. However, there was significant variation in the use of surveillance among different practices and urology practitioners. This highlights the need to improve practice patterns to enhance national prostate cancer outcomes.

JAMA NETWORK OPEN (2023)

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Article Oncology

Prostate cancer grade migration and facility-level treatment trends for grade group 1 disease

Leonardo D. Borregales et al.

Summary: Overdiagnosis and overtreatment of low-grade prostate cancer have prompted changes to guidelines and we found a significant decline in the incidence of Gleason Grade Group (GG) 1 PCa. Active surveillance (AS) uptake has increased, but there is still heterogeneity in its utilization, indicating room for improvement.

JNCI CANCER SPECTRUM (2023)

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Article Medicine, General & Internal

Trends in Incidence of Metastatic Prostate Cancer in the US

Mihir M. Desai et al.

Summary: Analysis of the recent SEER data reveals a significant increase in the incidence rates of mPCa, which coincides with the USPSTF recommendations against PCa screening. These trends are observed across different races and age groups and are associated with changes in screening practices.

JAMA NETWORK OPEN (2022)

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Article Medicine, General & Internal