Intelligent Jellyfish-type Janus Nanoreactor Targeting Synergistic Treatment of Bacterial Infections

Infections caused by multidrug-resistant bacteria continueto posea serious threat to human health, and therefore it is important toexplore the availability of antimicrobial drugs and modalities. Herein,jellyfish-type irregular mesoporous iron oxide nanoreactors containingciprofloxacin, Janus Fe3O4@mSiO(2)@Cipnanoparticles (JFmS@Cip NPs), were developed for pH-responsive synergisticantimicrobial therapy in a microacidic environment. Compared withthe use of symmetric nanocarriers, the asymmetric decoration on bothsides of the particles allows different components to act on bacteria,Fe3O4 NPs have good magnetic and peroxidase-likecatalytic activity, and the antibiotic ciprofloxacin can kill bacteriaefficiently. Notably, due to the synergistic effect between differentcomponents of Janus particles, in vitro antibacterialexperiments showed that JFmS@Cip NPs can kill bacteria efficientlyat low concentrations, reaching an antibacterial rate of 99.6%. JFmS@CipNPs combine multiple antibacterial properties that can be used toimprove the therapeutic efficacy of current nanomedicines againstdrug-resistant bacteria.

Automated summary

In order to address the serious threat of infections caused by multidrug-resistant bacteria, researchers have developed jellyfish-like irregular mesoporous iron oxide nanoreactors that can efficiently kill bacteria through synergistic action of different components.