期刊
MATERIALS TODAY
卷 19, 期 5, 页码 274-283出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mattod.2015.11.025
关键词
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资金
- Natural Science Foundation of Jiangsu Province of China [BK20150029]
- Six Talent Peaks Project of Jiangsu Province of China
- Jiangsu Specially-Appointed Professors Program
- CPU High-Level Talent Program
- NIH's Clinical and Translational Science Awards (CTSA) at UNC-CH [1UL1TR001111]
- CPU
- NC TraCS
- Joint BME Department of UNC-CH
- Joint BME Department of NC State
Cancer-associated stimuli-responsive nanosystems have been increasingly considered for the delivery of anticancer drugs, which primarily target the tumor microenvironment and/or intracellular elements to enhance intratumoral accumulation and promote drug release at the target site. The signals facilitating drug delivery include tumor and endocytic acidities, hypoxia, enzyme overexpression, as well as high levels of intracellular glutathione, reactive oxygen species, and adenosine-50-triphosphate. This article reviews the current techniques and ongoing developments in anticancer drug delivery using these signals. In particular, the focus is placed on design strategies and methods of formulating novel nanoscaled materials. The merits and drawbacks of recent strategies, as well as potential future developments, are discussed.
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