☆ 4.3 Review

Engineering Cell-ECM-Material Interactions for Musculoskeletal Regeneration

BIOENGINEERING-BASEL (2023)

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Article Green & Sustainable Science & Technology

Level of Activity Changes Increases the Fatigue Life of the Porous Magnesium Scaffold, as Observed in Dynamic Immersion Tests, over Time

Risky Utama Putra et al.

Summary: This study investigates the impact of human physiological activity levels on the fatigue life of a porous magnesium scaffold. Dynamic immersion and biomechanical testing were conducted to simulate physiological conditions. Numerical data analysis and computer simulations were used to predict implant failure values. The findings suggest that activity levels play a crucial role in implant fatigue rate.

SUSTAINABILITY (2023)

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Article Biochemistry & Molecular Biology

The Effect of Tortuosity on Permeability of Porous Scaffold

Akbar Teguh Prakoso et al.

Summary: Permeability is an important factor to consider in the design of porous scaffolds for cell migration and bone tissue regeneration. This study developed a porous scaffold based on the morphological indices of cancellous bone and analyzed fluid flow through the scaffold using computational fluid dynamics. The permeability of the scaffold was compared to that of natural cancellous bone and different scaffold types. The results showed that the Negative Schwarz Primitive (NSP) scaffold had similar permeability to natural cancellous bone and could be manipulated by changing the curvature to support cell migration and tissue regeneration.

BIOMEDICINES (2023)

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Article Engineering, Biomedical

Rejuvenation of tendon stem/progenitor cells for functional tendon regeneration through platelet-derived exosomes loaded with recombinant Yap1

Jinwei Lu et al.

Summary: This study reveals that the downstream effector of the Hippo pathway, Yap, is involved in tendon aging and repair processes and is associated with the regenerative capabilities of TSPCs. Platelet-derived exosomes loaded with recombinant Yap1 effectively inhibit oxidative stress-induced senescence and promote tendon regeneration. Additionally, the functionalized GelMA hydrogel with parallel-aligned substrate structure enhances TSPCs adhesion and stemness for tendon rejuvenation.

ACTA BIOMATERIALIA (2023)

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Article Biochemistry & Molecular Biology

Tethered TGF-β1 in a Hyaluronic Acid-Based Bioink for Bioprinting Cartilaginous Tissues

Julia Hauptstein et al.

Summary: In this study, a hyaluronic acid-based bioink was developed that allowed for the covalent tethering of TGF-beta 1, a growth factor important for cartilage regeneration. The functionality of the tethered TGF-beta 1 was successfully demonstrated in promoting chondrogenesis and maintaining its activity after 3D printing.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Physiology

Diaphragm muscle fibrosis involves changes in collagen organization with mechanical implications in Duchenne muscular dystrophy

Ridhi Sahani et al.

Summary: In Duchenne muscular dystrophy, dysfunction of the diaphragm muscle leads to respiratory insufficiency. The accumulation of fibrotic tissue and changes in collagen organization contribute to increased muscle stiffness. Understanding the structure and mechanics of fibrotic tissue is crucial in predicting the mechanical properties of the extracellular matrix (ECM) and its impact on diaphragm muscle function.

JOURNAL OF APPLIED PHYSIOLOGY (2022)

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Review Biophysics

The Role of the Non-Collagenous Extracellular Matrix in Tendon and Ligament Mechanical Behavior: A Review

Lainie E. Eisner et al.

Summary: This article summarizes the contribution of non-collagenous ECM to tendon and ligament mechanics and highlights the knowledge gaps that need to be addressed in future studies. It discusses the role of non-collagenous ECM in the quasi-static and viscoelastic behavior of tendons and ligaments under tension, compression, and shear, with insights from theoretical mechanics and biology.

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME (2022)

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Article Biochemistry & Molecular Biology

O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development

Sanjiv Neupane et al.

Summary: This study reveals the importance of O-fucose modification of extracellular matrix (ECM) associated proteins in embryonic and musculoskeletal development. By deleting the POFUT2 gene, researchers observed limb and bone abnormalities, as well as shortened tendons, resembling musculoskeletal dysplasias in humans and mice with mutations in ADAMTS or ADAMTSL proteins. Additionally, the study suggests that O-fucose modification may influence the function of POFUT2 substrates in the extracellular environment.

MATRIX BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

CCN2 participates in overload-induced skeletal muscle hypertrophy

Jennifer M. Petrosino et al.

Summary: The regulation of skeletal muscle growth following pro-hypertrophic stimuli requires the involvement of different cell types and matricellular proteins, such as CCN2, play a key role in facilitating the communication and signaling necessary for muscle adaptation. Through genetic engineering mouse models, this study demonstrated that CCN2 is essential for the hypertrophic response of muscle to mechanical stimuli. It was found that CCN2 regulates focal adhesion kinase (FAK) mediated transduction of extracellular signals, including interleukin 6 (IL6), and affects global protein synthesis in skeletal muscle.

MATRIX BIOLOGY (2022)

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Article Medicine, General & Internal

Prevention of postoperative adhesions after flexor tendon repair with acellular dermal matrix in Zones III, IV, and V of the hand A randomized controlled (CONSORT-compliant) trial

Yeon Ji Lee et al.

Summary: This study demonstrates the effectiveness of using acellular dermal matrix (ADM) in preventing postoperative adhesions and improving functional outcomes in patients with tendon injuries in the hand.

MEDICINE (2022)

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Article Biotechnology & Applied Microbiology

The anti-fibrotic agent nintedanib protects chondrocytes against tumor necrosis factor-alpha (TNF-alpha)-induced extracellular matrix degradation

Chuankun Wang et al.

Summary: Nintedanib may have a protective effect on chondrocytes by reducing oxidative stress, inflammation, and extracellular matrix damage, thus improving osteoarthritis. Its mechanism of action may be associated with the PKA/CREB signaling pathway.

BIOENGINEERED (2022)

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Article Biochemistry & Molecular Biology

Methacrylated Cartilage ECM-Based Hydrogels as Injectables and Bioinks for Cartilage Tissue Engineering

Kevin Behan et al.

Summary: Articular cartilage has limited healing potential, leading to the development of degenerative diseases such as osteoarthritis. Current clinical strategies aim to regenerate articular cartilage, but recreating a fully functional, load-bearing tissue remains a significant challenge due to a lack of biomaterials that mimic native tissue and provide appropriate regeneration cues.

BIOMOLECULES (2022)

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Article Cell Biology

The role of the tendon ECM in mechanotransduction: disruption and repair following overuse

Monideepa Chatterjee et al.

Summary: Tendon overuse injuries result in changes in the extracellular matrix (ECM) composition and structure, disrupting mechanotransduction and negatively impacting repair processes. Different loading profiles in various tendon types lead to diverse downstream mechanical stimuli. Alterations in ECM structure and properties at multiple scales can cause inadequate repair and disease progression.

CONNECTIVE TISSUE RESEARCH (2022)

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Article Cell & Tissue Engineering

Photoreactive Hydrogel Stiffness Influences Volumetric Muscle Loss Repair

Ivan M. Basurto et al.

Summary: This report investigates the role of hydrogel mechanical properties in the repair of volumetric muscle loss (VML) injuries. The study shows that an intermediate hydrogel stiffness of 3 kPa improves and sustains regenerative outcomes and attenuates chronic inflammation in a rat model. These findings provide valuable insights for the design of hydrogels for skeletal muscle tissue engineering and regeneration.

TISSUE ENGINEERING PART A (2022)

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Review Biochemical Research Methods

Extracellular matrix dynamics: tracking in biological systems and their implications

Michael Hu et al.

Summary: The extracellular matrix (ECM) plays a crucial role in providing mechanical support and mediating biochemical interactions for cells. Understanding the dynamic changes in ECM composition and structure is essential for studying tissue homeostasis and disease progression. This review discusses the mechanisms of ECM-cell interactions, the modulation of tissue development and disease progression by ECM changes, and the implications of ECM dynamics in tissue engineering.

JOURNAL OF BIOLOGICAL ENGINEERING (2022)

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Review Cell Biology

Into the Tissues: Extracellular Matrix and Its Artificial Substitutes: Cell Signalling Mechanisms

Aleksandra Bandzerewicz et al.

Summary: The existence of orderly structures like tissues and organs is possible by cell adhesion, a process where cells attach to neighbouring cells and extracellular matrix. The extracellular matrix, composed of collagens, elastin, proteoglycans, and glycoproteins, serves as a storehouse for signaling factors. Tissue disruption may require the use of implants for reconstitution, detailing the host response and surface properties modifications.

CELLS (2022)

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Article Biotechnology & Applied Microbiology

Personalized in vitro Extracellular Matrix Models of Collagen VI-Related Muscular Dystrophies

Enrico Almici et al.

Summary: This study engineered a personalized pre-clinical model of COL6-RDs using cell-derived matrices (CDMs) technology and found alterations in ECM structure and composition in COL6-RD patients. These models may serve as promising tools to explore the pathology of COL6-RDs, identify novel biomarkers, and investigate new therapeutic targets and treatments.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Materials Science, Multidisciplinary

3D Bioprinting of human Mesenchymal Stem Cells in a novel tunic decellularized ECM bioink for Cartilage Tissue Engineering

Mano Govindharaj et al.

Summary: In this study, decellularized extracellular matrix (dECM) scaffolds and bioinks from tunicates were developed for cartilage tissue engineering. The tunicate dECM preserved its natural microstructure and functional groups. The scaffolds and bioprinted structures showed enhanced cell proliferation and chondrogenic differentiation. This study provides a biologically compatible and mechanically stable source for cartilage tissue engineering.

MATERIALIA (2022)

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Article Engineering, Biomedical

The PCK2-glycolysis axis assists three-dimensional-stiffness maintaining stem cell osteogenesis

Zheng Li et al.

Summary: This study reveals the role of extracellular matrix stiffness in regulating stem cell fate and the novel mechanism of mitochondrial phosphoenolpyruvate carboxykinase in promoting osteogenesis in 3D matrix. These findings provide new perspectives for strategies of osteoporosis.

BIOACTIVE MATERIALS (2022)

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Article Multidisciplinary Sciences

Matrix stiffness and architecture drive fibro-adipogenic progenitors' activation into myofibroblasts

Taryn Loomis et al.

Summary: This study demonstrates that fibrotic muscle stiffness can activate FAPs to become myofibroblasts through YAP signaling, driving the progression of muscle fibrosis. However, fibrotic collagen architecture actually inhibits myofibroblast activation through a YAP independent mechanism.

SCIENTIFIC REPORTS (2022)

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Article Cell & Tissue Engineering

Tenogenic induction of human adipose-derived stem cells by soluble tendon extracellular matrix: composition and transcriptomic analyses

Ying Rao et al.

Summary: This study demonstrates that urea-extracted tECM contains abundant protein components and can enhance the proliferation and tenogenic differentiation of hASCs. Comparative analysis with Col1 reveals the potential mechanism of tECM's pro-tenogenic bioactivity.

STEM CELL RESEARCH & THERAPY (2022)

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Article Materials Science, Multidisciplinary

Study on bioactive PEGDA/ECM hybrid bi-layered hydrogel scaffolds fabricated by electro-writing for cartilage regeneration

Yu Han et al.

Summary: In this study, a hybrid cell hydrogel ink was developed based on electro-writing technology for constructing a bioactive cartilage repair scaffold. The scaffold showed a layered structure and was able to functionally repair damaged cartilage when implanted in the body.

APPLIED MATERIALS TODAY (2022)

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Article Biochemistry & Molecular Biology

The Rheology and Printability of Cartilage Matrix-Only Biomaterials

Emi A. Kiyotake et al.

Summary: This study aimed to increase the stiffness and printability of cartilage matrix-based hydrogels by modifying them with methacryloylating reagents. The hydrogel with 2 ME MA showed the best printability and stiffness, approaching the modulus of native cartilage, while supporting cell viability and adhesion.

BIOMOLECULES (2022)

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Article Engineering, Biomedical

Decellularized extracellular matrix: New promising and challenging biomaterials for regenerative medicine

Mika Brown et al.

Summary: Extracellular matrix is a promising biomaterial candidate for regenerative medicine applications due to its rich biomolecules. Decellularized extracellular matrix (dECM) has been developed in various forms, such as injectable hydrogels, electrospun scaffolds, and bioprinted scaffolds, to engineer different tissue types. This review paper highlights the challenges, fabrication methods, and progress made for each tissue type, aiming to push dECM biomaterials towards effective and specialized tissue repair.

BIOMATERIALS (2022)

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Article Biotechnology & Applied Microbiology

Research on the osteogenesis and biosafety of ECM-Loaded 3D-Printed Gel/SA/58sBG scaffolds

Guozhong Tan et al.

Summary: This study explores the use of scaffolds containing cell-derived extracellular matrix (ECM) for bone defect regeneration and demonstrates their advantages. Gelatin, sodium alginate, and 58s bioactive glass are combined with deionized water to form ink, which is then used for 3D printing of composite scaffolds. Rat aortic endothelial cells (RAOECs) or rat bone mesenchymal stem cells (RBMSCs) are seeded on the scaffold, which is then decellularized to obtain ECM-loaded scaffolds. The scaffold's morphology is assessed by scanning electron microscopy, while its effects on RBMSCs proliferation, adhesion, osteogenic differentiation, and angiogenic differentiation are evaluated using staining and PCR techniques.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Review Biotechnology & Applied Microbiology

Engineering Extracellular Microenvironment for Tissue Regeneration

Dake Hao et al.

Summary: This review highlights the importance of the extracellular microenvironment and introduces engineering approaches and technologies for controlling cell behavior and tissue regeneration. By engineering different components and monitoring methods, a higher degree of control over cellular activities and behaviors can be achieved, leading to innovative tissue engineering strategies for regenerative medicine.

BIOENGINEERING-BASEL (2022)

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Article Orthopedics

Stiffness- and Bioactive Factor-Mediated Protection of Self-Assembled Cartilage against Macrophage Challenge in a Novel Co-Culture System

Ryan P. Donahue et al.

Summary: This study showed that the stiffness of neocartilage can affect the behavior of macrophages, and the use of bioactive factors can protect neocartilage from macrophage-induced degradation.

CARTILAGE (2022)

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Review Pathology

Mechanical Feed-Forward Loops Contribute to Idiopathic Pulmonary Fibrosis

Margaret A. T. Freeberg et al.

Summary: Idiopathic pulmonary fibrosis is a progressive disease characterized by accumulation of extracellular matrix in lung tissue, leading to altered mechanical properties. Recent studies suggest that these changes create a feed-forward loop, contributing to fibroblast differentiation and activation. Mechanotransduction pathways, including mechanosensors like integrins and downstream transcription factors, play a role in fibrosis progression.

AMERICAN JOURNAL OF PATHOLOGY (2021)

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Article Clinical Neurology

Extracellular matrix remodelling is associated with muscle force increase in overloaded mouse plantaris muscle

A. Stantzou et al.

Summary: TGF-beta signaling contributes to ECM remodeling in dystrophic muscle, leading to increased muscle mass and force. Lack of myostatin is not advantageous, and inhibition of ECM deposition by halofuginone is disadvantageous for muscle plasticity in response to stimuli that induce dystrophic muscle.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2021)

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Article Chemistry, Physical

ILC1 drive intestinal epithelial and matrix remodelling

Geraldine M. Jowett et al.

Summary: Type-1 innate lymphoid cells drive intestinal epithelial proliferation and extracellular matrix remodelling through TGF-beta 1 secretion, which could exacerbate inflammatory bowel disease comorbidities such as cancer and fibrosis.

NATURE MATERIALS (2021)

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Review Engineering, Biomedical

The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration

Zhi Peng et al.

Summary: Osteoarthritis (OA) is a leading cause of disability and socioeconomic loss globally, with current pharmacological treatments mainly palliative. Focus is shifting towards targeting cartilage extracellular matrix (ECM) destruction and abnormal homeostasis in OA for regenerative therapies, using potential biomarkers and preclinical studies to identify pathological stages.

BIOMATERIALS (2021)

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Article Biochemistry & Molecular Biology

Bioprinting of Cartilage with Bioink Based on High-Concentration Collagen and Chondrocytes

Evgeny E. Beketov et al.

Summary: The study aimed to assess the applicability of a bioink containing 4% collagen and chondrocytes for de novo cartilage formation, with in vivo data showing successful formation of cartilage tissue with distinct structure and components.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy

Hongtao Chen et al.

Summary: Blocking COX-2 inhibited fibrogenesis after muscle atrophy induced by injury and suppressed AKT signaling pathway by inhibiting upstream PDK1 expression, preventing the recruitment of TRAF4 to AKT, indicating that COX-2/PDK1/AKT signaling pathway could be a potential target for treating muscle atrophy in the future.

REDOX BIOLOGY (2021)

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Article Multidisciplinary Sciences

Trabecular bone organoid model for studying the regulation of localized bone remodeling

Yongkuk Park et al.

Summary: A tissue-engineered model is described that replicates bone tissue complexity and remodeling processes, allowing for further investigation into trabecular bone niche biology.

SCIENCE ADVANCES (2021)

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Review Biology

The Role of Fibrosis in Osteoarthritis Progression

Yeri Alice Rim et al.

Summary: Osteoarthritis is a chronic degenerative joint disease characterized by cartilage degeneration and synovial membrane inflammation, which may eventually require joint replacement surgery. Joint fibrosis is a critical issue for understanding the disease, but the related characteristics are still largely misunderstood.

LIFE-BASEL (2021)

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Article Engineering, Biomedical

Muscle functional recovery is driven by extracellular vesicles combined with muscle extracellular matrix in a volumetric muscle loss murine model

Fabio Magarotto et al.

Summary: In this study, muscle ECM and human MSC EVs were used to promote tissue regeneration in a VML murine model, leading to enhanced angiogenesis and myogenesis, reduced fibrosis, and a shift of inflammation towards tissue repair.

BIOMATERIALS (2021)

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Review Orthopedics

The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis

Nader Salari et al.

Summary: This study conducted a systematic review and meta-analysis to investigate the global prevalence of osteoporosis. The results showed an overall prevalence of 18.3%, with higher rates in women (23.1%) compared to men (11.7%). Africa had the highest prevalence of osteoporosis at 39.5%.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2021)

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Article Biology

Modeling the ACVR1R206H mutation in human skeletal muscle stem cells

Emilie Barruet et al.

Summary: This study elucidated the impact of ACVR1 on skeletal muscle repair using fibrodysplasia ossificans progressiva. Rare primary FOP human muscle stem cells showed abnormal ECM marker expression and impaired skeletal muscle-specific engraftment and regeneration ability. Single-cell transcriptome analysis revealed increased expression of ECM and osteogenic markers in FOP patient-derived muscle stem/progenitor cells.

ELIFE (2021)

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Article Dermatology

Preventing postoperative adhesions after hand tendon repair using acellular dermal matrix

Hyung Sup Shim et al.

Summary: The study demonstrated that the use of ADM can significantly improve the range of motion in tendon surgery and enhance patient satisfaction.

JOURNAL OF WOUND CARE (2021)

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Review Biotechnology & Applied Microbiology

Strategies for Articular Cartilage Repair and Regeneration

Yanxi Liu et al.

Summary: Articular cartilage is avascular and has limited ability to repair itself, leading to degenerative joint diseases. Current clinical treatments often result in mechanically inferior cartilage. Understanding factors affecting cartilage homeostasis and exploring emerging regenerative approaches are crucial for future treatment options.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Engineering, Biomedical

In situ bone regeneration with sequential delivery of aptamer and BMP2 from an ECM-based scaffold fabricated by cryogenic free-form extrusion

Tingfang Sun et al.

Summary: In situ tissue engineering utilizing a novel delivery system with sequential release of bioactive molecules has shown promising results in promoting bone regeneration and cell activities. The study demonstrates enhanced bone formation in critical-sized defects with the sequential release system, suggesting its potential as an ideal alternative for cell-free scaffold-based bone regeneration.

BIOACTIVE MATERIALS (2021)

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Article Biochemical Research Methods

Measuring the elastic modulus of soft culture surfaces and three-dimensional hydrogels using atomic force microscopy

Michael D. A. Norman et al.

Summary: This protocol outlines how to utilize atomic force microscopy for measuring the elastic modulus of soft 2D surfaces and cell-laden 3D hydrogels. It includes instructions for sample preparation, instrument calibration, data collection and analysis, and inferring differential matrix remodeling activity in hydrogels. The protocol is suitable for probing a variety of synthetic and naturally derived polymeric hydrogels and allows users to characterize the mechanical properties of multiple surfaces or hydrogels in a single day with introductory AFM training.

NATURE PROTOCOLS (2021)

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Article Multidisciplinary Sciences

FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy

A. J. Wood et al.

Summary: Mutations in FKRP cause muscular dystrophies with diverse clinical presentations. In addition to targeting alpha-dystroglycan, FKRP also guides the sialylation of fibronectin, which is essential for collagen recruitment to the muscle basement membrane.

NATURE COMMUNICATIONS (2021)

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Article Engineering, Biomedical

Decellularized tendon matrix membranes prevent post-surgical tendon adhesion and promote functional repair

Meihan Tao et al.

Summary: In this study, an anti-adhesion membrane, DTM, was successfully prepared from homologous extracellular matrix using an optimized decellularization method. DTM showed potential to prevent tendon adhesion and improve tendon repair quality, with proven bioactivity retention and biocompatibility. High-throughput proteomics technology was used to analyze DTM's protein components, providing valuable scientific support for its application.

ACTA BIOMATERIALIA (2021)

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Review Engineering, Biomedical

Impact of perlecan, a core component of basement membrane, on regeneration of cartilaginous tissues

Gongming Gao et al.

Summary: Perlecan (Pln) is an essential component in the extracellular matrix and plays a crucial role in cartilaginous tissue function. This review outlines the structure, biomechanical properties, and signaling pathways of Pln, as well as its potential applications in cartilage regeneration.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Physical

Promotion of Bone Regeneration Using Bioinspired PLGA/MH/ECM Scaffold Combined with Bioactive PDRN

Da-Seul Kim et al.

Summary: The study combined porous PLGA scaffold with magnesium hydroxide and bone-extracellular matrix, as well as incorporated bioactive polydeoxyribonucleotide to create a PMEP scaffold with pro-osteogenic and pro-angiogenic effects. The results showed that the PMEP scaffold had superior biological properties for human bone-marrow mesenchymal stem cells adhesion, proliferation, and osteogenic differentiation.

MATERIALS (2021)

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Article Engineering, Biomedical

Hierarchical macro-microporous WPU-ECM scaffolds combined with Microfracture Promote in Situ Articular Cartilage Regeneration in Rabbits

Mingxue Chen et al.

Summary: This study constructed WPU and WPU-ECM scaffolds utilizing decellularized cartilage extracellular matrix and waterborne polyurethane, achieving hierarchical macro-microporous structures. The optimized WPU-ECM scaffold showed improved cell distribution, adhesion, and proliferation, facilitating the production of glycosaminoglycan and collagen as well as the upregulation of cartilage-specific genes. In vivo studies demonstrated successful regeneration of hyaline cartilage with similar histological structure and mechanical performance to normal cartilage using the hierarchical macro-microporous WPU-ECM scaffold.

BIOACTIVE MATERIALS (2021)

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Article Oncology

Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids

Md Soriful Islam et al.

Summary: Injections of collagenase into uterine fibroids led to a reduction in stiffness, inhibited cell growth, and decreased key factors promoting fibroid growth. Inhibition of YAP signaling pathway showed promising effects in suppressing cell proliferation and fibrosis-related pathways in fibroid cells, suggesting a potential therapeutic strategy for uterine fibroids.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Cell Biology

Comparison between placental and skeletal muscle ECM: in vivo implantation

Carla Maria F. Carvalho et al.

Summary: This study compared the regenerative effects of decellularized canine placentas and murine skeletal muscles in rat skeletal muscles. Results showed a higher percentage of proliferative cells in placental matrices compared to muscle matrices, with placental matrices not completely degraded at day 15. Both matrices were eventually resorbed, with morphologically normal myofibers observed after 45 days.

CONNECTIVE TISSUE RESEARCH (2021)

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Review Engineering, Biomedical

ECM in Differentiation: A Review of Matrix Structure, Composition and Mechanical Properties

Abinash Padhi et al.

ANNALS OF BIOMEDICAL ENGINEERING (2020)

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Review Biotechnology & Applied Microbiology

Extracellular matrix-derived biomaterials in engineering cell function

Hao Xing et al.

BIOTECHNOLOGY ADVANCES (2020)

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Article Engineering, Biomedical

Enzymatically crosslinked silk and silk-gelatin hydrogels with tunable gelation kinetics, mechanical properties and bioactivity for cell culture and encapsulation

Onur Hasturk et al.

BIOMATERIALS (2020)

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Article Engineering, Biomedical

Decellularized tissue engineered hyaline cartilage graft for articular cartilage repair

Xiaolei Nie et al.

BIOMATERIALS (2020)

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Article Engineering, Biomedical

A method for the assessment of the coefficient of friction of articular cartilage and a replacement biomaterial

Humaira Mahmood et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2020)

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Review Cell Biology

Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasis

Zhenxing Zhao et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Engineering, Biomedical

The effect of BMP-mimetic peptide tethering bioinks on the differentiation of dental pulp stem cells (DPSCs) in 3D bioprinted dental constructs

Ji Hoon Park et al.

BIOFABRICATION (2020)

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Review Physiology

Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review

Robert Csapo et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Article Materials Science, Multidisciplinary

Functionalization of extracellular matrix (ECM) on multichannel biphasic calcium phosphate (BCP) granules for improved bone regeneration

Reiza D. Ventura et al.

MATERIALS & DESIGN (2020)

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Article Medicine, Research & Experimental

Immobilization after injury alters extracellular matrix and stem cell fate

Amanda K. Huber et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Cell Biology

Potential of Soluble Decellularized Extracellular Matrix for Musculoskeletal Tissue Engineering - Comparison of Various Mesenchymal Tissues

Hiroto Hanai et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Cell-Derived Extracellular Matrix for Tissue Engineering and Regenerative Medicine

Marisa Assuncao et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Characterization of Functional Human Skeletal Myotubes and Neuromuscular Junction Derived-From the Same Induced Pluripotent Stem Cell Source

Xiufang Guo et al.

BIOENGINEERING-BASEL (2020)

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Article Biochemistry & Molecular Biology

Denervation-induced skeletal muscle fibrosis is mediated by CTGF/CCN2 independently of TGF-β

Daniela L. Rebolledo et al.

MATRIX BIOLOGY (2019)

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Review Medical Laboratory Technology

The cellular basis of fibrotic tendon healing: challenges and opportunities

Anne E. C. Nichols et al.

TRANSLATIONAL RESEARCH (2019)

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Review Pharmacology & Pharmacy

Targeted cell delivery for articular cartilage regeneration and osteoarthritis treatment

Nahid Nasiri et al.

DRUG DISCOVERY TODAY (2019)

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Article Cell Biology

SPARCL1 promotes C2C12 cell differentiation via BMP7-mediated BMP/TGF-β cell signaling pathway

YuXin Wang et al.

CELL DEATH & DISEASE (2019)

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Article Multidisciplinary Sciences

In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration

Meifeng Zhu et al.

NATURE COMMUNICATIONS (2019)

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Review Cell & Tissue Engineering

Tendon Stem/Progenitor Cells and Their Interactions with Extracellular Matrix and Mechanical Loading

Chuanxin Zhang et al.

STEM CELLS INTERNATIONAL (2019)

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Article Biochemistry & Molecular Biology

TGFβ2-induced tenogenesis impacts cadherin and connexin cell-cell junction proteins in mesenchymal stem cells

Sophia K. Theodossiou et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Engineering, Biomedical

Subcutaneously engineered autologous extracellular matrix scaffolds with aligned microchannels for enhanced tendon regeneration Aligned microchannel scaffolds for tendon repair

Wen Li et al.

BIOMATERIALS (2019)

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Article Cell & Tissue Engineering

BIOFABRICATION OF MULTISCALE BONE EXTRACELLULAR MATRIX SCAFFOLDS FOR BONE TISSUE ENGINEERING

F. E. Freeman et al.

EUROPEAN CELLS & MATERIALS (2019)

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Article Engineering, Biomedical

Multifunctional pH sensitive 3D scaffolds for treatment and prevention of bone infection

Monica Cicuendez et al.

ACTA BIOMATERIALIA (2018)

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Article Engineering, Biomedical

Mesenchymal stem cell-derived extracellular matrix enhances chondrogenic phenotype of and cartilage formation by encapsulated chondrocytes in vitro and in vivo

Yuanheng Yang et al.

ACTA BIOMATERIALIA (2018)

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Review Pharmacology & Pharmacy

Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair

Timothy J. Keane et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

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Article Oncology

Reduced substrate stiffness promotes M2-like macrophage activation and enhances peroxisome proliferator-activated receptor γ expression

Takayuki Okamoto et al.

EXPERIMENTAL CELL RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Osteoarthritis as a disease of the cartilage pericellular matrix

Farshid Guilak et al.

MATRIX BIOLOGY (2018)

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Article Cell & Tissue Engineering

Bioinspired Three-Dimensional Human Neuromuscular Junction Development in Suspended Hydrogel Arrays

Thomas Anthony Dixon et al.

TISSUE ENGINEERING PART C-METHODS (2018)

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Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling

Arul Subramanian et al.

ELIFE (2018)

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Article Biochemical Research Methods

Cell-derived matrices for studying cell proliferation and directional migration in a complex 3D microenvironment

Riina Kaukonen et al.

NATURE PROTOCOLS (2017)

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Article Multidisciplinary Sciences

Treatment of rabbit growth plate injuries with oriented ECM scaffold and autologous BMSCs

Wenchao Li et al.

SCIENTIFIC REPORTS (2017)

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Article Engineering, Biomedical

Instructing Human Macrophage Polarization by Stiffness and Glycosaminoglycan Functionalization in 3D Collagen Networks

Markus Friedemann et al.

ADVANCED HEALTHCARE MATERIALS (2017)

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Article Orthopedics

Superficial Zone Extracellular Matrix Extracts Enhance Boundary Lubrication of Self-Assembled Articular Cartilage

Gordon Peng et al.

CARTILAGE (2016)

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Article Engineering, Biomedical

Decellularized human placenta chorion matrix as a favorable source of small-diameter vascular grafts

Karl Heinrich Schneider et al.

ACTA BIOMATERIALIA (2016)

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Review Oncology

Nanoscale and mechanical properties of the physiological cell-ECM microenvironment

Jennifer L. Young et al.

EXPERIMENTAL CELL RESEARCH (2016)

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Article Engineering, Biomedical

Elastic, silk-cardiac extracellular matrix hydrogels exhibit time-dependent stiffening that modulates cardiac fibroblast response

Whitney L. Stoppel et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2016)

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Review Cell Biology

Integrin-mediated mechanotransduction

Zhiqi Sun et al.

JOURNAL OF CELL BIOLOGY (2016)

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Review Rheumatology

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

William H. Robinson et al.

NATURE REVIEWS RHEUMATOLOGY (2016)

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Review Orthopedics

Matrix scaffolding for stem cell guidance toward skeletal muscle tissue engineering

Claudia Fuoco et al.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2016)

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Review Medicine, General & Internal

Differences among skeletal muscle mass indices derived from height-, weight-, and body mass index-adjusted models in assessing sarcopenia

Kyoung Min Kim et al.

KOREAN JOURNAL OF INTERNAL MEDICINE (2016)

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Article Engineering, Biomedical

pH-responsive scaffolds generate a pro-healing response

Jin-Oh You et al.

BIOMATERIALS (2015)

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Article Biochemistry & Molecular Biology

A Polymorphism at the Translation Start Site of the Vitamin D Receptor Gene Is Associated with the Response to Anti-Osteoporotic Therapy in Postmenopausal Women from Southern Italy

Valeria Conti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

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Article Orthopedics

Tendon Functional Extracellular Matrix

Hazel R. C. Screen et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2015)

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Article Chemistry, Physical

Atomic force microscopy in biomaterials surface science

Fabio Variola

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2015)

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Article Engineering, Mechanical

Investigation of the nano-mechanical properties and surface topographies of wear particles and human knee cartilages

Meiling Wang et al.

WEAR (2015)

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Article Multidisciplinary Sciences

Decellularized Cartilage May Be a Chondroinductive Material for Osteochondral Tissue Engineering

Amanda J. Sutherland et al.

PLOS ONE (2015)

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Article Multidisciplinary Sciences

Substrate Stiffness Regulates Proinflammatory Mediator Production through TLR4 Activity in Macrophages

Michelle L. Previtera et al.

PLOS ONE (2015)

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Review Developmental Biology

Role of Chondrocytes in Cartilage Formation, Progression of Osteoarthritis and Cartilage Regeneration

Hemanth Akkiraju et al.

JOURNAL OF DEVELOPMENTAL BIOLOGY (2015)

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Article Biotechnology & Applied Microbiology

The Potential of Encapsulating Raw Materials'' in 3D Osteochondral Gradient Scaffolds

Neethu Mohan et al.

BIOTECHNOLOGY AND BIOENGINEERING (2014)

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Article Engineering, Biomedical

3D braid scaffolds for regeneration of articular cartilage

Hyunchul Ahn et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2014)

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Review Medicine, Research & Experimental

Extracellular matrix production in vitro in cartilage tissue engineering

Jie-Lin Chen et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2014)

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Review Cell Biology

Mechanotransduction and extracellular matrix homeostasis

Jay D. Humphrey et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

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Article Cell Biology

An Acellular Biologic Scaffold Promotes Skeletal Muscle Formation in Mice and Humans with Volumetric Muscle Loss

Brian M. Sicari et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

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Review Pathology

The role of the non-collagenous matrix in tendon function

Chavaunne T. Thorpe et al.

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2013)

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Review Biotechnology & Applied Microbiology

Extracellular matrix scaffolds for cartilage and bone regeneration

Kim E. M. Benders et al.

TRENDS IN BIOTECHNOLOGY (2013)

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Review Biotechnology & Applied Microbiology

The Role of Changes in Extracellular Matrix of Cartilage in the Presence of Inflammation on the Pathology of Osteoarthritis

Maricela Maldonado et al.

BIOMED RESEARCH INTERNATIONAL (2013)

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Article Engineering, Biomedical

The effects of substrate stiffness on the in vitro activation of macrophages and in vivo host response to poly(ethylene glycol)-based hydrogels

Anna K. Blakney et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2012)

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Article Surgery

Biologic Scaffold Remodeling in a Dog Model of Complex Musculoskeletal Injury

Neill J. Turner et al.

JOURNAL OF SURGICAL RESEARCH (2012)

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Article Orthopedics

Sliding motion modulates stiffness and friction coefficient at the surface of tissue engineered cartilage

S. Grad et al.

OSTEOARTHRITIS AND CARTILAGE (2012)

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Article Cell Biology

Wnt Signaling in Bone Development and Disease: Making Stronger Bone with Wnts

Jean B. Regard et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)

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Article Multidisciplinary Sciences

Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics

Murat Guvendiren et al.

NATURE COMMUNICATIONS (2012)

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Article Endocrinology & Metabolism

Osteocyte Signaling in Bone

Mitchell B. Schaffler et al.

CURRENT OSTEOPOROSIS REPORTS (2012)

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Review Materials Science, Multidisciplinary

Nanomechanics of the Cartilage Extracellular Matrix

Lin Han et al.

ANNUAL REVIEW OF MATERIALS RESEARCH, VOL 41 (2011)

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Review Engineering, Biomedical

An overview of tissue and whole organ decellularization processes

Peter M. Crapo et al.

BIOMATERIALS (2011)

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Review Biochemistry & Molecular Biology

Matrix control of scarring

Cecelia C. Yates et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2011)

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Article Orthopedics

Volumetric Muscle Loss

Brian F. Grogan et al.

JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS (2011)

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Review Clinical Neurology

STRUCTURE AND FUNCTION OF THE SKELETAL MUSCLE EXTRACELLULAR MATRIX

Allison R. Gillies et al.

MUSCLE & NERVE (2011)

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Review Rheumatology

The pathogenesis of tendinopathy: balancing the response to loading

S. Peter Magnusson et al.

NATURE REVIEWS RHEUMATOLOGY (2010)

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Article Cell Biology

Understanding the effect of mean pore size on cell activity in collagen-glycosaminoglycan scaffolds

Ciara M. Murphy et al.

CELL ADHESION & MIGRATION (2010)

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Article Engineering, Biomedical

Effect of pore size on ECM secretion and cell growth in gelatin scaffold for articular cartilage tissue engineering

Sio-Mei Lien et al.

ACTA BIOMATERIALIA (2009)

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Article Biochemistry & Molecular Biology

Evidence against proteoglycan mediated collagen fibril load transmission and dynamic viscoelasticity in tendon

Gion Fessel et al.

MATRIX BIOLOGY (2009)

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Article Cell & Tissue Engineering

Macrophage Participation in the Degradation and Remodeling of Extracellular Matrix Scaffolds

Jolene E. Valentin et al.

TISSUE ENGINEERING PART A (2009)

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Article Engineering, Biomedical

A cartilage ECM-derived 3-D porous acellular matrix scaffold for in vivo cartilage tissue engineering with PKH26-labeled chondrogenic bone marrow-derived mesenchymal stem cells

Qiang Yang et al.

BIOMATERIALS (2008)

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Review Orthopedics

The basic science of tendinopathy

Yinghua Xu et al.

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2008)

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Optimizing collagen transport through track-etched nanopores

Ericka M. Bueno et al.

JOURNAL OF MEMBRANE SCIENCE (2008)

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Article Biochemistry & Molecular Biology

Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche

Yanming Bi et al.

NATURE MEDICINE (2007)

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Article Biochemistry & Molecular Biology

Influence of the extracellular matrix on the frictional properties of tissue-engineered cartilage

M. Plainfosse et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2007)

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Article Engineering, Biomedical

The influence of swelling and matrix degradation on the microstructural integrity of tendon

Hazel R. C. Screen et al.

ACTA BIOMATERIALIA (2006)

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Article Orthopedics

Rotator cuff repair using an acellular dermal matrix graft: An in vivo study in a canine model

Julie E. Adams et al.

ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY (2006)

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Article Anatomy & Morphology

Extracellular matrix adaptation of tendon and skeletal muscle to exercise

M Kjær et al.

JOURNAL OF ANATOMY (2006)

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Article Engineering, Biomedical

Effectiveness of three extraction techniques in the development of a decellularized bone-anterior cruciate ligament-bone graft

T Woods et al.

BIOMATERIALS (2005)

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Review Engineering, Biomedical

Porosity of 3D biomaterial scaffolds and osteogenesis

V Karageorgiou et al.

BIOMATERIALS (2005)

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Article Biochemistry & Molecular Biology

Characterisation of proteoglycans and their catabolic products in tendon and explant cultures of tendon

T Samiric et al.

MATRIX BIOLOGY (2004)

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Review Neurosciences

Elasticity in extracellular matrix 'shape modules' of tendon, cartilage, etc. A sliding proteoglycan-filament model

JE Scott

JOURNAL OF PHYSIOLOGY-LONDON (2003)

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