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Article
Biotechnology & Applied Microbiology
Akshay Ravish et al.
Summary: This study explored the design of imidazopyridine-tethered pyrazolines as a de novo drug strategy for inhibiting STAT3 phosphorylation in human BC cells. Compound 3f with 2,3-dichlorophenyl substitution was recognized among the tested series as a lead structure that inhibited the viability of MCF-7 cells. It effectively inhibited STAT3 phosphorylation in MCF-7 and T47D cells, indicating that these structures may be an alternative synthon to target STAT3 signaling in BC.
BIOENGINEERING-BASEL
(2023)
Review
Biotechnology & Applied Microbiology
Fahad Alabdah et al.
Summary: Osteoporosis is a skeletal disease that affects bone mechanical properties. It is a major problem for patients and healthcare systems worldwide. This review aims to analyze articles related to the treatment of osteoporotic patients undergoing total hip replacement and discuss the findings and implications.
BIOENGINEERING-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Silvia Vieira et al.
Summary: This study aims to develop a stable injectable Mn-based methacrylated gellan gum (Mn/GG-MA) hydrogel for real-time monitored cell delivery into the central nervous system. By supplementing GG-MA solutions with paramagnetic Mn2+ ions, the hydrogel can be visualized under Magnetic Resonance Imaging (MRI). Cell-laden hydrogels prepared using the Mn/GG-MA formulations remained viable after 7 days of culture. In vivo tests on immunocompromised mice showed that the injection of Mn/GG-MA solutions resulted in a continuous and traceable hydrogel visible on MRI scans. Overall, the developed formulations are suitable for non-invasive cell delivery techniques and image-guided neurointerventions.
BIOENGINEERING-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Prabaha Sikder et al.
Summary: This paper presents the development and analysis of design-specific and bioactive piezoelectric scaffolds for orthopedic defect treatment using extrusion-based 3D printing. The study demonstrates that 3D-printed piezoelectric scaffolds coupled with clinical ultrasonic stimulation have the potential to expedite bone regeneration. The results show that the scaffold's pore size and the frequency of ultrasonic stimulation have significant effects on pre-osteoblast behavior.
BIOENGINEERING-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Yousef Khazaei Monfared et al.
Summary: This study tested the anticoagulant effect of cyclodextrin hyper-branched-based polymers and found that they can effectively reduce the free quantity of calcium ions in blood and prolong blood clotting time. Additionally, these polymers showed better coagulant characteristics compared to ethylenediaminetetraacetic acid and exhibited different abilities in complexing calcium ions.
BIOENGINEERING-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Miriam Salas-Monedero et al.
Summary: The objective of this study was to analyze the feasibility of using the Xiaomi Mi Band 5 wristband (XMB5) for heart rate (HR) monitoring in cervical spinal cord injury (SCI) patients during upper limb activities. The results showed a strong positive correlation between the HR measurements from XMB5 and the professional medical equipment Nonin LifeSense II capnograph and pulse oximeter (NLII) in healthy individuals. Therefore, the XMB5 wristband seems to be a feasible option for HR measurement in this biomedical application in SCI patients.
BIOENGINEERING-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Vinoda B. Patil et al.
Summary: In this research, a nanostructured zinc oxide nanoparticle-modified carbon paste electrode (ZnO/CPE) was used along with an anionic surfactant and sodium dodecyl sulphate (SDS) to detect trimethoprim (TMP) through voltametric techniques. The electrode showed higher peak current than the original CPE. Various parameters such as pH, immersion time, scan rate, and concentration were studied. The TMP electrode process was found to be irreversible and diffusion controlled with two electrons transferred. The developed electrode proved effective in detecting TMP in pharmaceutical dosages and urine samples, indicating its potential in clinical and pharmaceutical sample analysis.
BIOENGINEERING-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Ali Ikhsanul Qauli et al.
Summary: The study found that mexiletine can effectively treat LQT3 patients associated with the A1656D mutation by shortening the cell's action potential duration, changing the occurrence of alternans, and reducing the chances of spiral wave breakup.
BIOENGINEERING-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Zhiyong Zhao et al.
Summary: Poly(ethylene glycol) (PEG) films are used as porous and bioinert matrix for immobilization and hybridization of single-stranded DNA (ssDNA). Immobilization is achieved through the reaction between amine groups in the films and NHS-ester-decorated ssDNA. The strategy can be applied to the fabrication of DNA microarrays and DNA sensors, with electrochemical impedance spectroscopy suggested as a suitable transduction technique.
BIOENGINEERING-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Hamed Osouli Tabrizi et al.
Summary: This paper presents a CMOS capacitive sensing platform for analyzing oral cells, which contributes to early detection and control of periodontal diseases. The experimental and simulation results demonstrate the functionality and applicability of the proposed sensor for monitoring cells in small saliva samples.
BIOENGINEERING-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Rajamanickam Ricky et al.
Summary: In this study, the growth and biochemical composition of Chlorella vulgaris under antibiotic stress were investigated. The results showed that C. vulgaris can adapt to antibiotic contamination and remove CIP and AMX, while increasing the production of valuable biomass.
BIOENGINEERING-BASEL
(2022)
Review
Biotechnology & Applied Microbiology
Hanieh Gholizadeh et al.
Summary: This article discusses the application of in vitro human organ models in preclinical drug testing. Conventional in vitro tissue models and animal models have failed to accurately predict the clinical success of new therapies. Organ-on-chip technology provides realistic tissue models that mimic the physiological characteristics of human organs and has been successfully applied in drug testing.
BIOENGINEERING-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Federico Arippa et al.
Summary: The unilaterality of motor symptoms in Parkinson's disease is associated with motor deficits and limitations in functional abilities. This study investigated gait alterations and interlimb asymmetry in a cohort of Parkinson's disease patients using 3D gait analysis. The results showed significant differences in gait patterns and interlimb coordination compared to unaffected individuals. These findings could be useful for early diagnosis and disease progression evaluation.
BIOENGINEERING-BASEL
(2022)
Review
Engineering, Multidisciplinary
Guoguang Rong et al.
