4.3 Review

Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Chemistry, Inorganic & Nuclear

Pharmacological aspects of schiff base metal complexes: A critical review

Tuba Ashraf et al.

Summary: Multidrug-resistant infections have posed a major health issue with financial burdens. Organic compounds with pure organic mechanisms have shown improved potential through the incorporation of trace amounts of metal ions. Schiff base metal complexes have gained attention for their pharmacological applications in treating challenging diseases, providing innovative opportunities between inorganic and organic compounds.

INORGANIC CHEMISTRY COMMUNICATIONS (2023)

Article Chemistry, Medicinal

Benzothiazole as a Promising Scaffold for the Development of Antifungal Agents

Christophe Tratrat

Summary: Despite efforts in the discovery of antifungal drugs, increasing incidence of fungal infectious diseases poses a threat to public healthcare. Current antifungal agents face concerns like resistance, side effects, toxicity, and limited activity spectrum. Therefore, the urgent exploration of novel compounds with potential antifungal activity is necessary.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2023)

Article Chemistry, Applied

Co(II), Ni(II), Cu(II), and Zn(II) metal complexes of chalcone: Synthesis, characterization, thermal, antimicrobial, photocatalytic degradation of dye and molecular modeling studies

Jino Johnson et al.

Summary: Thiazole-based chalcone ligand and its metal complexes were synthesized and characterized, with their molecular structures, properties, and application in dye removal studied.

APPLIED ORGANOMETALLIC CHEMISTRY (2022)

Article Chemistry, Medicinal

Novel benzothiazole-based dual VEGFR-2/EGFR inhibitors targeting breast and liver cancers: Synthesis, cytotoxic activity, QSAR and molecular docking studies

Eman A. Abd El-Meguid et al.

Summary: A series of benzothiazole-based derivatives were synthesized and showed promising cytotoxic activities, as well as inhibitory activities against VEGFR-2 and EGFR. Some derivatives exhibited potent activity against resistant cell lines. QSAR study revealed the impact of molecular bulkiness and molecular partial charge distribution on the kinase inhibition potency in this series. Molecular docking study showed that the synthesized derivatives adopted the common binding pattern of type II PK inhibitors in VEGFR-2.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2022)

Review Chemistry, Organic

Recent Advances in the Synthesis of Benzothiazole and its Derivatives

Tanzeela Qadir et al.

Summary: Benzothiazole derivatives have been extensively studied in the fields of synthetic and medicinal chemistry due to their significant pharmaceutical properties. These compounds exhibit a wide range of biological activities, including anti-inflammatory, anticancer, and antibacterial effects. This review discusses various reaction methods for the synthesis of different benzothiazole derivatives.

CURRENT ORGANIC CHEMISTRY (2022)

Review Chemistry, Medicinal

Anti-viral activity of thiazole derivatives: an updated patent review

Thoraya A. Farghaly et al.

Summary: Viral infections pose serious threats to human health, and there is still no comprehensive treatment for many important viral infections. Therefore, the development of new, safe, and effective antiviral drugs is crucial.

EXPERT OPINION ON THERAPEUTIC PATENTS (2022)

Article Chemistry, Physical

Pharmacological and Molecular docking studies of new copper (II) complexes of N2-Phenyl-N4,N6-di(thiazol-2-yl)-1,3,5-triazine-2,4,6-triamine

M. Vathanaruba et al.

Summary: A new series of copper(II) complexes based on tri substituted 1,3,5-triazine ligand have been synthesized and characterized. The complexes exhibit significant antibacterial, anticonvulsant, and anti-inflammatory activities in vitro and in vivo.

JOURNAL OF MOLECULAR STRUCTURE (2022)

Review Biochemistry & Molecular Biology

Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents

Mohammed F. Arshad et al.

Summary: Thiazole is an important heterocycle in chemistry, possessing aromatic properties and reactive positions. Molecules with a thiazole ring can have various effects in physiological systems, making them a focus of research for medicinal chemists aiming to develop new therapeutic agents.

MOLECULES (2022)

Article Chemistry, Medicinal

Seeking heterocyclic scaffolds as antivirals against dengue virus

Soumik De et al.

Summary: This review highlights the significance of inhibitory and antiviral activities of nitrogen, oxygen, and mixed heterocyclic scaffolds for potential antiviral drug candidates against the dengue virus. It also discusses the mechanisms of action, structure-activity relationships, and the viral infection life cycle in host cells. The diversity of heterocycles and their SARs will contribute to the development of promising anti-dengue drug candidates in the future.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

Review Chemistry, Physical

Thiazole derivatives in medicinal chemistry: Recent advancements in synthetic strategies, structure activity relationship and pharmacological outcomes

Atamjit Singh et al.

Summary: Thiazole derivatives are important heterocycles in medicinal chemistry, with widespread biological activities. This review summarizes recent advancements in the medicinal chemistry of thiazole derivatives, including marketed drugs, therapeutic candidates, synthesis methods, biological significances, and structure-activity relationships.

JOURNAL OF MOLECULAR STRUCTURE (2022)

Review Chemistry, Medicinal

Advancement in Pharmacological Activities of Benzothiazole and its Derivatives: An Up to Date Review

Sumit et al.

Summary: Benzothiazole is a significant bioactive compound with a wide presence in natural products, showing potential applications in drug research.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2021)

Review Chemistry, Organic

A Mini-Review on Pharmacological Importance of Benzothiazole Scaffold

Mohammad Asif et al.

Summary: Heterocyclic compounds play a key role in drug development due to their diverse pharmacological properties. This review focuses on benzothiazole and its derivatives, which exhibit a wide range of pharmacological activities, including antimicrobial, anti-inflammatory, analgesic, and anticancer properties. Structural modifications have led to the development of benzothiazole derivatives with various pharmacological activities.

MINI-REVIEWS IN ORGANIC CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives

Anca-Maria Borcea et al.

Summary: Thiazole, a key heteroaromatic ring, is a crucial scaffold in many synthetic compounds, with diverse pharmacological activities found in clinically approved molecules. Numerous biologically active thiazole and bisthiazole derivatives have been reported, encouraging further research on thiazole-containing drugs.

MOLECULES (2021)

Article Chemistry, Physical

Spectral, modeling and biological studies on a novel (E)-3-(3-bromo-4-methoxyphenyl)-1-(thiazol-2-yl)prop-2-en-1-one and some bivalent metal(II) complexes

Jino Johnson et al.

Summary: A novel thiazole-based chalcone ligand and its metal complexes were synthesized and characterized with various techniques. The metal complexes exhibited higher antimicrobial activity compared to the free ligand. Molecular docking interactions were found to be consistent with the experimental microbial activities.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Article Chemistry, Physical

Quantum Chemical, experimental spectroscopic, Hirshfeld surface and molecular docking studies of the anti-microbial drug Sulfathiazole

Aysha Fatima et al.

Summary: The study focused on the quantum chemical investigation, surface analysis, and NMR experiments of Sulfathiazole (ST), providing insights into its molecular structure, crystal interactions, and optical properties. Results showed that ST is a potent antimicrobial drug with significant implications in the pharmaceutical sector.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Article Chemistry, Multidisciplinary

Aminothiazole-Linked Metal Chelates: Synthesis, Density Functional Theory, and Antimicrobial Studies with Antioxidant Correlations

Sadaf Noreen et al.

Summary: In this study, new aminothiazole Schiff base ligands were designed, characterized, and tested for various activities including metal chelation, bioactivity, antimicrobial action, antifungal properties, and antioxidant activity. The results demonstrated their effectiveness in these areas and highlighted the importance of metal complexes and LUMO energies on their activities.

ACS OMEGA (2021)

Article Chemistry, Multidisciplinary

Green chemistry approaches for thiazole containing compounds as a potential scaffold for cancer therapy

Diksha Sharma et al.

Summary: This article discusses the recent advancements in green chemistry-based synthesis of thiazole derivatives with anticancer potential. Thiazole scaffold is widely used in drug development, with a drug approved for breast cancer treatment.

SUSTAINABLE CHEMISTRY AND PHARMACY (2021)

Review Biochemistry & Molecular Biology

Modern Approaches to the Synthesis and Transformations of Practically Valuable Benzothiazole Derivatives

Larisa V. Zhilitskaya et al.

Summary: The review highlights the modern trends in the chemistry of 2-amino and 2-mercapto substituted benzothiazoles since 2015, focusing on their biological and industrial significance. It discusses newly developed synthesis methods, including one-pot, atom economy procedures, and emphasizes the potential of these compounds as highly reactive building blocks for organic and organoelement synthesis, including pharmacologically active heterocycles. The review also suggests that the findings presented may be valuable for developing new drugs, materials, and synthetic approaches.

MOLECULES (2021)

Review Biochemistry & Molecular Biology

Thiazole Ring-A Biologically Active Scaffold

Anthi Petrou et al.

Summary: Thiazole is a valuable pharmacophore nucleus with a wide range of biological activities, including antioxidant, analgesic, antimicrobial, antihypertensive, anti-inflammatory, and antipsychotic properties. Recent literature review identified and critically analyzed nearly 124 research articles on the synthesis and biological activities of thiazoles derivatives in the past 5 years.

MOLECULES (2021)

Article Biochemistry & Molecular Biology

Bioactive Co(II), Ni(II), and Cu(II) Complexes Containing a Tridentate Sulfathiazole-Based (ONN) Schiff Base

Aurora Reiss et al.

Summary: In this study, new Co(II), Ni(II), and Cu(II) complexes were synthesized and characterized using various techniques. The experimental results showed that the structures and properties of the complexes, as well as their antibacterial activity, were superior to those of the Schiff base ligand.

MOLECULES (2021)

Review Chemistry, Organic

SYNTHETIC APPROACHES TOWARD CERTAIN STRUCTURALLY RELATED ANTIMICROBIAL THIAZOLE DERIVATIVES (2010-2020)

Abdelfattah Hassan et al.

Summary: In this literature review, various methods of synthesizing antimicrobial thiazole derivatives published in the past decade are comprehensively discussed, with a focus on those exhibiting antibacterial, antimycobacterial, and/or antifungal activity. The diversity of thiazole-derived antimicrobial agents is highlighted through categorization into chemical classes, showcasing the common methods of thiazole ring closure and the antimicrobial activity of the most potent derivatives.

HETEROCYCLES (2021)

Article Chemistry, Inorganic & Nuclear

Tailoring copper(II) complexes with pyridine-4,5-dicarboxylate esters for anti-Candida activity

Tina P. Andrejevic et al.

Summary: Five novel copper(ii) complexes with pyridine-4,5-dicarboxylate esters as ligands were synthesized and characterized, showing antimicrobial activity against Candida species. These complexes effectively inhibited the biofilm formation and adhesion of Candida albicans, highlighting their potential as antifungal agents. The interaction of the copper(ii) complexes with ct-DNA and bovine serum albumin was also investigated, revealing their mechanism of antifungal activity.

DALTON TRANSACTIONS (2021)

Review Chemistry, Medicinal

Thiazole-containing compounds as therapeutic targets for cancer therapy

Prabodh Chander Sharma et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Benzothiazole derivatives as anticancer agents

Ali Irfan et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2020)

Review Chemistry, Organic

A retrospect on antimicrobial potential of thiazole scaffold

Isha Mishra et al.

JOURNAL OF HETEROCYCLIC CHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Recent Advances in Synthesis of Benzothiazole Compounds Related to Green Chemistry

Xiang Gao et al.

MOLECULES (2020)

Review Chemistry, Medicinal

2,4,5-Trisubstituted Thiazole: A Privileged Scaffold in Drug Design and Activity Improvement

Zhen Zhang et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2020)

Review Chemistry, Inorganic & Nuclear

REVIEW: Biomedical applications of Schiff base metal complexes

Mohammad Nasir Uddin et al.

JOURNAL OF COORDINATION CHEMISTRY (2020)

Review Chemistry, Medicinal

A Review on Recent Synthetic Strategies and Pharmacological Importance of 1,3-Thiazole Derivatives

Swarnagowri Nayak et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2019)

Review Chemistry, Medicinal

Thiazole in the targeted anticancer drug discovery

Adileh Ayati et al.

FUTURE MEDICINAL CHEMISTRY (2019)

Review Chemistry, Medicinal

Recent advances of thiazole hybrids in biological applications

Mehmet Gumus et al.

FUTURE MEDICINAL CHEMISTRY (2019)

Review Chemistry, Medicinal

Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review

Chuang Zhao et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Chemistry, Applied

Nickel(II) and copper(II) complexes of 2,2'-bibenzo[d]thiazole: Synthesis, characterisation and biological studies

Omaka N. Omaka et al.

APPLIED ORGANOMETALLIC CHEMISTRY (2018)

Review Chemistry, Medicinal

Anticancer Potential of Thiazole Derivatives: A Retrospective Review

Shweta Jain et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2018)

Review Biochemistry & Molecular Biology

Heterocyclic Schiff base transition metal complexes in antimicrobial and anticancer chemotherapy

Manzoor Ahmad Malik et al.

MEDCHEMCOMM (2018)

Review Multidisciplinary Sciences

Schiff bases and their metal complexes as urease inhibitors - A brief review

Angelo de Fatima et al.

JOURNAL OF ADVANCED RESEARCH (2018)

Review Chemistry, Medicinal

Benzothiazole Derivatives as Potential Anti-Infective Agents

Prabodh Chander Sharma et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2017)

Review Chemistry, Organic

Benzothiazole: A Versatile and Multitargeted Pharmacophore in the Field of Medicinal Chemistry

Shikha Agarwal et al.

LETTERS IN ORGANIC CHEMISTRY (2017)

Review Chemistry, Physical

A Review on Synthesis of Benzothiazole Derivatives

Subhash Banerjee et al.

CURRENT ORGANOCATALYSIS (2017)

Review Chemistry, Medicinal

Thiazole: A Review on Chemistry, Synthesis and Therapeutic Importance of its Derivatives

Mahesh T. Chhabria et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2016)

Article Chemistry, Inorganic & Nuclear

Complexation of Cu(II) with cefotaxime in NaCl solution

E. V. Zhuravlev et al.

RUSSIAN JOURNAL OF INORGANIC CHEMISTRY (2016)

Review Chemistry, Medicinal

Thiazole: A promising heterocycle for the development of potent CNS active agents

Chandra Bhushan Mishra et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Review Chemistry, Medicinal

A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry

Rangappa S. Keri et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Review Oncology

Recent Patents on Thiazole Derivatives Endowed with Antitumor Activity

Rita Morigi et al.

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY (2015)

Review Biochemistry & Molecular Biology

Potential Role of Sulfur-Containing Antioxidant Systems in Highly Oxidative Environments

Emmanuel Mukwevho et al.

MOLECULES (2014)

Article Spectroscopy

Design, synthesis and DNA binding activities of late first row transition metal(II) complexes of bi-functional tri- and tetratopic imines

Priya P. Netalkar et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2012)

Article Spectroscopy

Phenoxide bridged tetranuclear Co(II), Ni(II), Cu(II) and Zn(II) complexes: Electrochemical, magnetic and antimicrobial studies

Anupama Kamath et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2011)

Article Biochemistry & Molecular Biology

Metal specificity in DNA damage prevention by sulfur antioxidants

Erin E. Battin et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2008)

Article Chemistry, Inorganic & Nuclear

New tetrachlorocyclodiphosph(V)azane complexes of Co(II), Ni(II), and Cu(II): Preparation, characterization, solid state electrical conductivity, and biological activity studies

Abdel-Nasser M. A. Alaghaz et al.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS (2008)

Article Chemistry, Multidisciplinary

Investigating the antioxidant properties of oxo-sulfur compounds on metal-mediated DNA damage

Ria R. Ramoutar et al.

MAIN GROUP CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Bactericidal activity of different oxovanadium(IV) complexes with Schiff bases and application of chelation theory

Pragnesh K. Panchal et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2006)

Review Medicine, General & Internal

Antioxidant effects of sulfur-containing amino acids

G Atmaca

YONSEI MEDICAL JOURNAL (2004)

Article Chemistry, Inorganic & Nuclear

Heterocyclo-substituted sulfa drugs: Part XII. Mercapto-S-azo-benzothiazol dyes and their metal complexes

IMA Awad et al.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS (2003)

Article Chemistry, Inorganic & Nuclear

Symmetric binuclear complexes with an 'end-off' compartmental Schiff base ligand

SM Annigeri et al.

TRANSITION METAL CHEMISTRY (2002)