Ion-Doped Calcium Phosphate-Based Coatings with Antibacterial Properties

Ion-substituted calcium phosphate (CP) coatings have been extensively studied as promising materials for biomedical implants due to their ability to enhance biocompatibility, osteoconductivity, and bone formation. This systematic review aims to provide a comprehensive analysis of the current state of the art in ion-doped CP-based coatings for orthopaedic and dental implant applications. Specifically, this review evaluates the effects of ion addition on the physicochemical, mechanical, and biological properties of CP coatings. The review also identifies the contribution and additional effects (in a separate or a synergistic way) of different components used together with ion-doped CP for advanced composite coatings. In the final part, the effects of antibacterial coatings on specific bacteria strains are reported. The present review could be of interest to researchers, clinicians, and industry professionals involved in the development and application of CP coatings for orthopaedic and dental implants.

Automated summary

Ion-substituted calcium phosphate (CP) coatings have been extensively studied for biomedical implants, showing enhanced biocompatibility, osteoconductivity, and bone formation. This systematic review comprehensively analyzes the effects of ion addition on the physicochemical, mechanical, and biological properties of CP coatings. The review also examines the synergistic effects of different components used with ion-doped CP for composite coatings, and reports on the antibacterial effects of these coatings on specific bacteria strains.