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Proteomic Research of Extracellular Vesicles in Clinical Biofluid

PROTEOMES (2023)

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Article Oncology

A large-scale targeted proteomics of plasma extracellular vesicles shows utility for prognosis prediction subtyping in colorectal cancer

Keiko Kasahara et al.

Summary: This study performed a large-scale targeted proteomics analysis of plasma extracellular vesicles to identify novel subtypes of colorectal cancer (CRC) and important biomarker proteins associated with these subtypes. Liquid biopsy assessment with targeted proteomics analysis was proposed to be crucial for predicting CRC prognosis.

CANCER MEDICINE (2023)

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Article Oncology

Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses

Ernesto Gargiulo et al.

Summary: This study investigated the interactions between cancer cells and the microenvironment using mouse models of chronic lymphocytic leukemia (CLL). It found that small extracellular vesicles (sEVs) derived from CLL tissue contain specific miRNA and immune-checkpoint ligands, which alter the function and exhaustion of CD8+ T cells. Blocking sEV biogenesis delayed CLL pathogenesis and high expression of sEV-related genes correlated with poor outcomes in CLL patients.

BLOOD CANCER DISCOVERY (2023)

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Article Oncology

Plasma extracellular vesicle microRNA profiling and the identification of a diagnostic signature for stage I lung adenocarcinoma

Shugeng Gao et al.

Summary: This study explored the profile of plasma EV-delivered miRNAs in patients with early-stage LUAD and developed a diagnostic signature comprising four EV-derived miRNAs for early detection of the disease, exhibiting high precision and the ability to recognize patients with AIS and MIA as well.

CANCER SCIENCE (2022)

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Article Oncology

miRNAs derived from plasma small extracellular vesicles predict organo-tropic metastasis of gastric cancer

Cheng Zhang et al.

Summary: This study investigated biomarkers for organo-tropic metastasis of gastric cancer (GC) from the perspective of small extracellular vesicle (sEV)-derived miRNAs. The expression profiles of sEV-miRNAs varied greatly across different metastatic patterns, and signatures were constructed to characterize and predict organo-tropic metastasis. The study also explored the impact of these biomarker miRNAs on GC's in vitro motility and discussed their potential involvement in cancer-related biological processes and pathways.

GASTRIC CANCER (2022)

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Article Multidisciplinary Sciences

MicroRNA sequence codes for small extracellular vesicle release and cellular retention

Ruben Garcia-Martin et al.

Summary: Research has shown that miRNAs have sorting sequences that determine their secretion in sEVs, different cell types preferentially use specific sorting sequences to define their sEV miRNA profile. Insertion or deletion of these sequences affects miRNA secretion. RNA-binding proteins Alyref and Fus are involved in the mechanism, leading to enhanced miRNA delivery and inhibition of target genes in distant cells.

NATURE (2022)

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Article Obstetrics & Gynecology

Extracellular vesicle-derived long non-coding RNA as circulating biomarkers for endometriosis

Shan Shan et al.

Summary: The combination of RP3-399L15.2 and CH507-513H4.6 may serve as potential biomarkers for endometriosis, and CH507-513H4.6 alone may be useful in detecting early-stage endometriosis lesions.

REPRODUCTIVE BIOMEDICINE ONLINE (2022)

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Article Chemistry, Multidisciplinary

Fine Particulate Matter Induces Childhood Asthma Attacks via Extracellular Vesicle-Packaged Let-7i-5p-Mediated Modulation of the MAPK Signaling Pathway

Rui Zheng et al.

Summary: The study revealed that PM2.5 exposure triggers HBE cells to secrete EVs that cause cytotoxicity and increase contractility of bronchial smooth muscle cells, activating the MAPK signaling pathway through let-7i-5p interaction with ELAVL1. EV-packaged let-7i-5p serves as a novel predictor of childhood asthma.

ADVANCED SCIENCE (2022)

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Article Immunology

Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response

Elisa Pesce et al.

Summary: This study compared exosomes recovered from the plasma of MILD or SEVERE COVID-19 patients and found that exosomes from MILD patients efficiently regulated immune responses, while those from SEVERE patients were associated with increased and chronic inflammation.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Cell Biology

Cannabinoids Reduce Extracellular Vesicle Release from HIV-1 Infected Myeloid Cells and Inhibit Viral Transcription

Catherine DeMarino et al.

Summary: Research shows that CBD significantly reduces the number of EVs released from infected cells, potentially mediated through decreasing viral transcription and autophagy activation. Therefore, CBD may exert a protective effect by alleviating the pathogenic effects of EVs in HIV-1 and CNS-related infections.

CELLS (2022)

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Article Cell Biology

Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain

Yang You et al.

Summary: In this study, the proteomic profiles of EVs derived from different types of neural cells were investigated. Cell type-specific EV protein markers were identified, and the role of astrocyte-specific EVs in Alzheimer's disease (AD) progression was explored. The hub protein ITGB1 was found to be significantly elevated in astrocyte-specific EVs and associated with AD pathology.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Article Chemistry, Analytical

One-Pot Exosome Proteomics Enabled by a Photocleavable Surfactant

Kevin M. Buck et al.

Summary: The one-pot exosome proteomics method using a photocleavable surfactant Azo simplifies exosomal lysis, protein extraction, and digestion, enabling fast, simple, and effective exosomal proteomics research with broad applications.

ANALYTICAL CHEMISTRY (2022)

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Review Biochemical Research Methods

Unraveling the complexity of the extracellular vesicle landscape with advanced proteomics

Julia Morales-Sanfrutos et al.

Summary: The field of EVs is rapidly advancing, with mass spectrometry-based proteomics providing new insights. Techniques for EV purification have inherent limitations, highlighting the need to accurately identify molecular constituents and study their functions in EVs.

EXPERT REVIEW OF PROTEOMICS (2022)

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Article Biochemistry & Molecular Biology

Proteomics and Phosphoproteomics of Circulating Extracellular Vesicles Provide New Insights into Diabetes Pathobiology

Yury O. Nunez Lopez et al.

Summary: This study identified EV proteomic and phosphoproteomic signatures in people with prediabetes and T2DM, offering novel insights into the pathobiology of diabetes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Comparative Proteomic Profiling of Secreted Extracellular Vesicles from Breast Fibroadenoma and Malignant Lesions: A Pilot Study

Katia Pane et al.

Summary: Extracellular vesicles (EVs) play a crucial role in cell-to-cell communication by shuttling proteins, RNA, DNA, and lipids. Recent studies have shown that EVs may also contribute to breast cancer growth and metastasis. This pilot study evaluated the physicochemical composition and proteomic profiles of EVs from benign and malignant breast cells, providing potential implications for precision medicine in breast cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Alteration of miRNAs in Small Neuron-Derived Extracellular Vesicles of Alzheimer's Disease Patients and the Effect of Extracellular Vesicles on Microglial Immune Responses

Devrim Yagmur Durur et al.

Summary: Alzheimer's disease (AD) is a severe neurodegenerative disease in the elderly population, and there is still a lack of definitive diagnosis and treatment methods. This study identified let-7e as a potential biomarker for AD diagnosis by studying the altered miRNA content in small neuron-derived extracellular vesicles (sNDEVs). Furthermore, it was found that AD patient-derived sNDEVs induce a neuroinflammatory response.

JOURNAL OF MOLECULAR NEUROSCIENCE (2022)

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Article Neurosciences

Novel Exosome Biomarker Candidates for Alzheimer's Disease Unravelled Through Mass Spectrometry Analysis

Tania Soares Martins et al.

Summary: Exosomes in blood can serve as biomarkers for the diagnosis of Alzheimer's disease (AD) and monitoring disease progression. Proteomic analysis identified 9 significantly different abundant proteins between healthy controls and AD cases, and their levels were validated using antibody-based approaches. These findings contribute to the development of blood-based tools for AD diagnosis.

MOLECULAR NEUROBIOLOGY (2022)

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Review Biochemical Research Methods

Clinical applications of plasma proteomics and peptidomics: Towards precision medicine

Bo He et al.

Summary: In the field of precision medicine, developing individualized treatment strategies based on molecular characteristics is crucial for overcoming therapeutic challenges caused by disease heterogeneity. Plasma proteomics and peptidomics have emerged as critical tools for developing novel precision medicine preventative measures, offering great potential in studying disease pathogenesis, identifying valuable biomarkers, and improving clinical management.

PROTEOMICS CLINICAL APPLICATIONS (2022)

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Article Medicine, Research & Experimental

Comparative proteomics identify HSP90A, STIP1 and TAGLN-2 in serum extracellular vesicles as potential circulating biomarkers for human adenomyosis

Dayong Chen et al.

Summary: Extracellular vesicles (EVs) carry specific proteins involved in intercellular communication. Recent studies have identified proteins in adenomyosis (AM)-derived EVs (AMEVs) from blood as potential biomarkers for this disease. This study analyzed tissue and blood AMEVs to identify proteins associated with adenomyosis and found potential biomarkers for diagnosis.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

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Article Multidisciplinary Sciences

Combining plasma extracellular vesicle Let-7b-5p, miR-184 and circulating miR-22-3p levels for NSCLC diagnosis and drug resistance prediction

G. P. Vadla et al.

Summary: Low-dose computed tomography (LDCT) Non-Small Cell Lung (NSCLC) screening has a high false-positive rate, and there is a need for minimally invasive approaches to improve the accuracy of NSCLC diagnosis. Additionally, NSCLC patients treated with Osimertinib often develop resistance, and the underlying mechanisms are not fully understood. This study found that a combination of plasma extracellular vesicle (EV) and circulating microRNA (miRNA) can effectively discriminate between NSCLC patients and high-risk cancer-free controls, and certain miRNAs play a role in cancer therapy resistance signals.

SCIENTIFIC REPORTS (2022)

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Article Microbiology

Plasma Exosomal Proteomic Pattern of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis

Yan Xie et al.

Summary: This study identifies potential biomarkers for the early diagnosis and clinical treatment of EBV-HLH by analyzing the differential plasma exosomal proteome of an EBV-HLH patient and his healthy twin brother. The differentially expressed proteins are related to virus infection, coagulopathy, nervous system dysfunction, imbalance of immune response, and abnormal liver function. These findings provide new insights into the diagnostic and therapeutic biomarkers of EBV-HLH.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Identification and evaluation of circulating small extracellular vesicle microRNAs as diagnostic biomarkers for patients with indeterminate pulmonary nodules

Di Zheng et al.

Summary: This study evaluated the diagnostic value of circulating small extracellular vesicle microRNAs in patients with indeterminate pulmonary nodules detected by low-dose computed tomography. A circulating sEV miRNA model was constructed and showed promise in distinguishing between benign and malignant nodules, providing insights into the development of diagnostic biomarkers.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Chemistry, Multidisciplinary

Exosome Processing and Characterization Approaches for Research and Technology Development

James J. Lai et al.

Summary: Exosomes, as extracellular vesicles, have potential as disease biomarkers and therapeutic agents. However, manufacturing high-quality exosomes is challenging due to the lack of standardized practices and reference materials. This review compares exosome processing and characterization methods, recommends exosome workflows, and provides an introduction to exosomes, including their properties and roles in biological processes and disease progression. It also summarizes ongoing clinical trials.

ADVANCED SCIENCE (2022)

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Article Oncology

Plasma extracellular vesicle long RNA profiling identifies a diagnostic signature for stage I lung adenocarcinoma

Wei Guo et al.

Summary: This study characterized the plasma exLR profile of early LUAD and developed an exLR-based diagnostic signature for the detection of LUAD. The signature exhibited high accuracy and could distinguish different types of LUAD.

TRANSLATIONAL LUNG CANCER RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Nebulization of extracellular vesicles: A promising small RNA delivery approach for lung diseases

Yohan Han et al.

Summary: sEVs, with a diameter up to 200 nm, can reflect the pathogenesis of human diseases and mediate intercellular communications. This study demonstrates that sEVs can be delivered to murine lungs through a vibrating mesh nebulizer and successfully loaded with small RNAs. Inhalation of siMyd88-loaded sEVs can reduce lipopolysaccharide-induced lung injury in mice.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Nanoscience & Nanotechnology

All-in-One Strategy for Downstream Molecular Profiling of Tumor-Derived Exosomes

Shurong Wang et al.

Summary: An all-in-one strategy based on nanoporous TiO2 clusters has been proposed for comprehensive characterization of exosomal proteins. This strategy allows efficient and specific isolation of exosomes, as well as highly efficient proteomic analysis. The approach has been successfully applied to the study of exosome markers and their functions, leading to the discovery of potential biomarkers and functional insights related to gastric cancer.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Discovering the Secret of Diseases by Incorporated Tear Exosomes Analysis via Rapid-Isolation System: iTEARS

Liang Hu et al.

Summary: This study introduces a rapid and efficient tear-exosomes analysis system called iTEARS, which uses nanotechnology to isolate nanoscale extracellular vesicles from a small volume of tears for the study of ocular disorders and systemic diseases. Through proteomic and transcriptomic analysis, numerous proteins and miRNAs were identified in tears, and potential biomarkers for dry eye disease and diabetic retinopathy were discovered.

ACS NANO (2022)

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Article Biochemistry & Molecular Biology

A pilot study using proximity extension assay of cerebrospinal fluid and its extracellular vesicles identifies novel amyotrophic lateral sclerosis biomarker candidates

Sebastian Sjoqvist et al.

Summary: The study analyzed cerebrospinal fluid (CSF) from ALS patients and identified several proteins that could potentially serve as biomarkers for the disease. These findings could contribute to the early diagnosis and treatment of ALS, as well as enhance our understanding of its pathology.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Article Physiology

Urinary extracellular vesicle as a potential biomarker of exercise-induced fatigue in young adult males

Suhong Park et al.

Summary: The study found that the number of urinary EVs significantly increased after exercise and returned to baseline levels after 1-hour rest. miRNA sequencing revealed alterations in four miRNAs pre- and post-exercise, suggesting that urinary EVs could potentially serve as a novel biomarker for acute exercise-induced fatigue.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2022)

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Article Clinical Neurology

Proteomic profiling of circulating plasma exosomes reveals novel biomarkers of Alzheimer's disease

Huimin Cai et al.

Summary: This study found that a combination of six proteins in plasma exosomes can accurately differentiate Alzheimer's disease patients from healthy individuals, suggesting its potential as a novel biomarker for AD diagnosis.

ALZHEIMERS RESEARCH & THERAPY (2022)

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Article Biochemistry & Molecular Biology

Characterization of the MicroRNA Cargo of Extracellular Vesicles Isolated from a Pulmonary Tumor-Draining Vein Identifies miR-203a-3p as a Relapse Biomarker for Resected Non-Small Cell Lung Cancer

Bing Han et al.

Summary: By analyzing the cargo of extracellular vesicles (EVs) from the tumor-draining vein of the lung, researchers have identified a promising new biomarker (EV-miR-203a-3p) for predicting post-surgical relapse in patients with non-small cell lung cancer (NSCLC).

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Pharmacology & Pharmacy

DNAJB6-Containing Extracellular Vesicles as Chaperone Delivery Systems: A Proteomic Analysis

Bhagyashree S. Joshi et al.

Summary: Cell-derived extracellular vesicles are considered as promising candidates for in vivo drug delivery due to their ability to enter cells and deliver cargo. This study investigated the transmission mechanism of DNAJB6 in EVs using HEK293T cells.

PHARMACEUTICS (2022)

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Article Cell Biology

Characterizing single extracellular vesicles by droplet barcode sequencing for protein analysis

Mahsan Banijamali et al.

Summary: Small extracellular vesicles (sEVs) have emerged as a valuable source of biomarkers for disease diagnosis and therapy monitoring. A new method called droplet barcode sequencing for protein analysis (DBS-Pro) has been developed to profile surface proteins on individual sEVs, enabling the identification of sEV subtypes. This method uses DNA barcoded affinity reagents and sequencing as readout to analyze multiple proteins in high throughput single vesicle profiling.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Article Oncology

Extracellular vesicles in cancer therapy

Shizhen Emily Wang

Summary: Extracellular vesicles (EVs) play a major role in intercellular communication in both physiological and pathological processes. Tumor-derived EVs contribute to cancer cell plasticity and resistance to therapy, adaptation of tumor microenvironment, vascular remodeling, immunomodulation, and establishment of pre-metastatic niches. Therefore, studying EVs and developing targeted therapies and diagnostic methods based on EVs is of great importance for cancer treatment.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Lipidomic identification of urinary extracellular vesicles for non-alcoholic steatohepatitis diagnosis

Qingfu Zhu et al.

Summary: This study investigates the lipid composition of urinary EVs and their potential as biomarkers for NASH detection. By analyzing the lipid profiles, a panel of lipid molecules is identified that can distinguish NASH with high accuracy. These lipid molecules are closely associated with the occurrence and development of NASH.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Cell Biology

Mesenchymal Stem Cell-Derived Extracellular Vesicles as Idiopathic Pulmonary Fibrosis Microenvironment Targeted Delivery

Lu Sang et al.

Summary: IPF is a disease affecting an increasing number of people globally with limited treatment options. Extracellular vesicles have shown extraordinary therapeutic effects in treating inflammation, fibrosis, and tissue damage, providing a new approach for IPF treatment.

CELLS (2022)

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Article Cell Biology

Proteomics, Phosphoproteomics and Mirna Analysis of Circulating Extracellular Vesicles through Automated and High-Throughput Isolation

Hao Zhang et al.

Summary: The magnetic bead-based EV enrichment approach (EVrich) allows for automated and high-throughput processing of urine samples, resulting in the identification of a large number of unique EV peptides and proteins. Phosphoproteomics analysis revealed specific proteins significantly elevated in prostate cancer patients. EVrich represents a universal and scalable platform for EV isolation, enabling downstream cargo analyses for both research and clinical applications.

CELLS (2022)

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Article Oncology

Expression and clinical value of circRNAs in serum extracellular vesicles for gastric cancer

Ke Xiao et al.

Summary: This study investigated the expression profile of serum Extracellular Vesicle circular RNAs (EV circRNAs) in gastric cancer (GC) patients and found that these circRNAs may serve as potential biomarkers for the diagnosis of GC.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

Serum Extracellular Vesicle Stratifin Is a Biomarker of Perineural Invasion in Patients With Colorectal Cancer and Predicts Worse Prognosis

Wenyun Hou et al.

Summary: In this study, quantitative proteomics was used to analyze serum-derived extracellular vesicles (EV) in colorectal cancer patients, revealing differences in proteomic profiles between PNI and NPNI groups. Stratifin (SFN) expression levels in EV were identified as a potential biomarker for distinguishing PNI from NPNI patients and as an independent predictor of CRC prognosis.

FRONTIERS IN ONCOLOGY (2022)

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Article Cell Biology

Neoantigen-based cancer vaccination using chimeric RNA-loaded dendritic cell-derived extracellular vesicles

Xiao Xiong et al.

Summary: This study demonstrates the potential of using cancer-specific transcription-induced chimeric RNAs to produce a cell-free cancer vaccine that induces potent CD8(+) T cell-mediated anticancer immunity. This novel approach may be particularly useful for developing cancer vaccines to treat malignancies with low mutational burden or without mutation-based antigens.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Review Cell Biology

A review on exosomes application in clinical trials: perspective, questions, and challenges

Jafar Rezaie et al.

Summary: Exosomes, as significant mediators of cell-to-cell communication, have promising applications in the treatment of various diseases. They can be used as biomarkers, cell-free therapeutic agents, and drug delivery carriers. However, there are challenges to overcome in the clinical application of exosomes, and further research and standardization are needed.

CELL COMMUNICATION AND SIGNALING (2022)

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Review Biochemistry & Molecular Biology

Tumor-derived exosomal non-coding RNAs as diagnostic biomarkers in cancer

Nasim Ebrahimi et al.

Summary: Reliable, accessible, and non-invasive biomarkers are crucial for reducing cancer mortality. Extracellular vesicles, particularly exosomes, have emerged as potential biomarkers for the diagnosis and follow-up of solid and hematopoietic tumors due to their abundance in bodily fluids and ability to transport various biomolecules. However, the lack of standardized effective methods for their isolation, identification, and precise characterization poses challenges for their clinical application.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Extracellular Vesicles in Diffuse Large B Cell Lymphoma: Characterization and Diagnostic Potential

Rune Matthiesen et al.

Summary: This study characterized and evaluated the proteome of plasma extracellular vesicles in DLBCL patients, and found that these proteins are closely associated with the status of DLBCL and may serve as prognostic markers for patient survival.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Neurosciences

Brain Tissue-Derived Extracellular Vesicles in Alzheimer's Disease Display Altered Key Protein Levels Including Cell Type-Specific Markers

Yiyao Huang et al.

Summary: This study profiles the proteomes of brain tissue and brain tissue-derived extracellular vesicles (bdEVs) in Alzheimer's disease (AD) patients to reveal the pathological mechanisms. Cell-specific markers on intact bdEVs were also analyzed to indicate targets for capturing and molecular profiling of bdEVs in the periphery. The findings suggest that several proteins in bdEVs are involved in AD mechanisms and may be used for disease monitoring.

JOURNAL OF ALZHEIMERS DISEASE (2022)

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Review Chemistry, Multidisciplinary

Apoptotic bodies for advanced drug delivery and therapy

Min Zhou et al.

Summary: Extracellular vesicles (EVs), including apoptotic bodies (ABs), have emerged as promising candidates for various biomedical applications. ABs, derived from parent cells during the final stages of apoptosis, possess diverse sources and stable morphological features. They accommodate more functional biomolecules due to their larger volume and exhibit advantageous interactions with recipient cells through their predominant body surface ratio. ABs hold great potential in modulating and alleviating symptoms of numerous diseases, and have also been applied in disease diagnosis, immunotherapy, regenerative therapy, and drug delivery.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Neurosciences

Trem2 deletion enhances tau dispersion and pathology through microglia exosomes

Bing Zhu et al.

Summary: This study found that Trem2 deletion can enhance the spreading of tau in the brain of mice, leading to impaired synaptic function and memory. Furthermore, Trem2 deletion can strengthen the ability of microglia to transmit tau through exosomal vesicles.

MOLECULAR NEURODEGENERATION (2022)

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Article Multidisciplinary Sciences

Fluid nanoporous microinterface enables multiscale-enhanced affinity interaction for tumor-derived extracellular vesicle detection

Qi Niu et al.

Summary: In this study, researchers developed a fluid nanoporous microinterface for efficient isolation of tumor-derived extracellular vesicles (T-EVs). By decorating lipid bilayers on nanoporous herringbone microstructures, they significantly enhanced the affinity of T-EVs to the interface, resulting in ultrasensitive detection and successful differentiation between cancer patients and healthy donors.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Multidisciplinary Sciences

Evaluation of circulating small extracellular vesicle-derived miRNAs as diagnostic biomarkers for differentiating between different pathological types of early lung cancer

Yi-fang Jiang et al.

Summary: This study revealed that plasma-derived sEV miRNAs can serve as diagnostic biomarkers for early-stage lung cancer (SCLC and NSCLC). Differential expression analysis identified specific miRNAs, and their potential functions and pathology-related miRNA modules were predicted.

SCIENTIFIC REPORTS (2022)

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Article Biology

Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study

Zicheng Hu et al.

Summary: Using host proteomics and transcriptomics, the trajectory of immune response in COVID-19 patients was characterized. Early immune markers were found to be associated with disease progression, control of viral shedding, and SARS-CoV-2-specific T cell and antibody responses. Machine-learning models accurately predicted patient outcomes.

ELIFE (2022)

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Article Respiratory System

Plasma Extracellular Vesicle miRNA Profiles Distinguish Chronic Obstructive Pulmonary Disease Exacerbations and Disease Severity

Hannah E. O'Farrell et al.

Summary: This preliminary study suggests that bioactive cargo (miRNAs) in plasma extracellular vesicles hold specific biological information for the severity of airflow obstruction and COPD exacerbations, warranting further investigation.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2022)

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Article Chemistry, Multidisciplinary

Large Oncosome-Loaded VAPA Promotes Bone-Tropic Metastasis of Hepatocellular Carcinoma Via Formation of Osteoclastic Pre-Metastatic Niche

Shuxia Zhang et al.

Summary: Tumor-derived extracellular vesicles play critical roles in generating a pre-metastatic microenvironment for organotropic metastasis. This study discovers the crucial role of large oncosomes in bone-tropic metastasis of hepatocellular carcinoma by engineering an osteoclastic pre-metastatic niche. The interaction between VAMP-associated protein A on large oncosomes and osteoclasts mediates the formation of the microenvironment and contributes to HCC bone metastasis.

ADVANCED SCIENCE (2022)

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Article Genetics & Heredity

Serum extracellular vesicle MicroRNAs as candidate biomarkers for acute rejection in patients subjected to liver transplant

Wenjing Wang et al.

Summary: Acute rejection (AR) is a common and serious complication of liver transplantation (LT). This study identified serum extracellular vesicle (EV) microRNAs (miRNAs) as potential biomarkers for AR in LT patients. The results showed that miR-223 and let-7e-5p were up-regulated, while miR-199a-3p was down-regulated, in AR patients compared to non-AR patients. These miRNAs can serve as promising diagnostic biomarkers for AR in patients subjected to liver transplant.

FRONTIERS IN GENETICS (2022)

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Article Biotechnology & Applied Microbiology

A light-activated magnetic bead strategy utilized in spatio-temporal controllable exosomes isolation

Chenhan Wang et al.

Summary: Tumor-derived exosomes are important biomarkers in liquid biopsy. A novel nanoplatform was developed for spatially and temporally controlled extraction and release of exosomes through magnetic separation and light activation, showing advantages over current ultracentrifugation methods.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Chemistry, Physical

Transcriptomic Features in a Single Extracellular Vesicle via Single-Cell RNA Sequencing

Tao Luo et al.

Summary: This study utilized the 10x Genomics platform to profile RNA cargos in single EVs derived from human K562 and mesenchymal stem cells, revealing a wide range of gene numbers and significant heterogeneity at the single-EV level. Marker genes in EVs demonstrated unique cell origins and features, providing insights into the understanding of EVs and their potential applications.

SMALL METHODS (2022)

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Review Biochemistry & Molecular Biology

Omics-based biomarkers discovery for Alzheimer's disease

Qiaolifan Aerqin et al.

Summary: This review summarizes the progress made in the discovery of reliable Alzheimer's disease (AD) biomarkers using genomics, transcriptomics, proteomics, and metabolomics. The importance of these biomarkers in the diagnosis and treatment of AD is discussed.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

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Article Chemistry, Multidisciplinary

A new integrated method for tissue extracellular vesicle enrichment and proteome profiling

Miaomiao Zhang et al.

Summary: Extracellular vesicles (EVs) are membranous vesicles released by cells and contain important components such as lipids, proteins, and mRNAs. EVs play a crucial role in cancer cell migration, invasion, angiogenesis, and cell survival in the tumor microenvironment. They also hold diagnostic and prognostic significance in various cancers. However, isolating pure EVs directly from tissue samples remains challenging. The current methods for EV isolation are time-consuming, instrumental dependent, have a low recovery rate, and limited purity. In this study, a novel isolation approach using an extraction kit combined with TiO2 microspheres (kit-TiO2) was developed. This approach improved the purity and enrichment efficiency of the isolated EVs. The study identified differentially expressed proteins in liver tissue EVs from healthy and hepatocellular carcinoma (HCC) bearing-mice, providing insights into HCC biomarkers and drug screening. The novel isolation strategy enables the direct enrichment of EVs from tissues and could be beneficial for biomedical and clinical research.

RSC ADVANCES (2022)

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Review Medicine, Research & Experimental

Small extracellular vesicles isolation and separation: Current techniques, pending questions and clinical applications

Yuanwang Jia et al.

Summary: Extracellular vesicles, especially small extracellular vesicles (sEVs), are important messengers in cell-to-cell communication and promising drug delivery platforms. However, the heterogeneity of their physicochemical properties and functions is not fully understood, limiting their clinical applications. This review provides up-to-date research on sEVs isolation methods, discusses their advantages and limitations, and reviews their applications in disease diagnosis and treatment.

THERANOSTICS (2022)

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Article Cell Biology

Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson's disease

Ozge Karayel et al.

Summary: The study presents a mass spectrometry-based workflow for analyzing the CSF proteome of Parkinson's disease (PD) patients. The workflow identifies several proteins that are altered in PD patients or significantly correlated with clinical scores, and reveals enhanced neuroinflammation in LRRK2 G2019S carriers. Comparison with urinary proteomes also demonstrates overlapping PD-associated changes, including lysosomal protein alterations, shedding light on the understanding of PD pathogenesis.

CELL REPORTS MEDICINE (2022)

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Article Biochemistry & Molecular Biology

A Comparison of Blood Plasma Small Extracellular Vesicle Enrichment Strategies for Proteomic Analysis

Natalie P. Turner et al.

Summary: This study evaluated different methods for proteomic analysis of small extracellular vesicles (sEVs). The UC + SEC method was found to be the best method for sEV enrichment, resulting in the highest number of protein identifications, improved purity, and particle yield.

PROTEOMES (2022)

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Article Immunology

Circulating extracellular vesicles as new inflammation marker in HIV infection

Katia Falasca et al.

Summary: Circulating levels of total extracellular vesicles, EMVs and LMVs were significantly lower in HIV+ patients compared to healthy subjects, while platelet-derived extracellular vesicles were higher in patients. Proteomic analysis revealed the upregulation of gammaIFN and IL1 alpha, and down-regulation of OSM, NF-kB, LIF, and RXRA signaling in these patients.

AIDS (2021)

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Review Pharmacology & Pharmacy

The Impact of Immune Cell-derived Exosomes on Immune Response Initiation and Immune System Function

Fataneh Tavasolian et al.

Summary: Exosomes are small extracellular vesicles that play a role in cell-to-cell communication by transferring genetic material. They are involved in various immune system functions such as antigen presentation, NK cell and T cell activation/polarisation, immune suppression, and anti-inflammatory processes. Exosomes have potential applications in immunotherapy as delivery vehicles.

CURRENT PHARMACEUTICAL DESIGN (2021)

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Article Oncology

Small extracellular vesicle-packaged TGFS1 promotes the reprogramming of normal fibroblasts into cancer-associated fibroblasts by regulating fibronectin in head and neck squamous cell carcinoma

Qiang Huang et al.

Summary: The study demonstrates that TGFS1 packaged in sEV can reprogram NFs into CAFs, shedding light on an important mechanism for cancer-recruited stroma responses.

CANCER LETTERS (2021)

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Review Biochemistry & Molecular Biology

Membrane Microvesicles as Potential Vaccine Candidates

Layaly Shkair et al.

Summary: The prevention and control of infectious diseases is crucial, with vaccination being an effective approach. Microvesicles are suggested as potential vehicles for antigen delivery, carrying various immunogenic molecules directly to target cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Multidisciplinary

Molecular Identification of Tumor-Derived Extracellular Vesicles Using Thermophoresis-Mediated DNA Computation

Yike Li et al.

Summary: The study introduces a novel DNA computation device mediated by thermophoresis for detecting tEVs, achieving high sensitivity and specificity in analysis, providing new opportunities for cancer diagnosis.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Biochemical Research Methods

Exosome detection via the ultrafast-isolation system: EXODUS

Yuchao Chen et al.

Summary: The study introduces an ultrafast isolation system called EXODUS for efficient purification of exosomes from biofluids, with superior speed, purity, and yield compared to other isolation techniques.

NATURE METHODS (2021)

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Article Chemistry, Analytical

Ultrasensitive electrochemiluminescence biosensor for the detection of tumor exosomes based on peptide recognition and luminol-AuNPs@g-C3N4 nanoprobe signal amplification

Xuejiao Liu et al.

Summary: This study developed a sandwich peptide-based ECL biosensor for sensitive and cost-effective determination of tumor exosomes. The biosensor showed superior performance with wider linear range and lower detection limit, and it could be applicable for determination of exosomes in complex biological samples. The combination of peptide recognition with nanoprobe as a label for signal amplification in sandwich ECL biosensing is a promising strategy.

TALANTA (2021)

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Article Oncology

Molecular Signature of Extracellular Vesicular Small Non-Coding RNAs Derived from Cerebrospinal Fluid of Leptomeningeal Metastasis Patients: Functional Implication of miR-21 and Other Small RNAs in Cancer Malignancy

Kyue-Yim Lee et al.

Summary: Leptomeningeal metastasis (LM) is a deadly complication where cancer spreads to the meninges, and currently lacks definitive treatments or diagnosis methods. This study suggests that examining small non-coding RNA populations of extracellular vesicles (EVs) derived from cerebrospinal fluid (CSF) may offer potential for diagnosis and treatment strategies. Systemic analysis revealed unique expression patterns of LM CSF EVs smRNAs compared to healthy donors, indicating their potential as novel biomarkers for LM pathogenesis and diagnosis.

CANCERS (2021)

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Article Chemistry, Multidisciplinary

Sequencing-Based Protein Analysis of Single Extracellular Vesicles

Jina Ko et al.

Summary: Circulating extracellular vesicles (EVs) are promising biomarkers and drug delivery vehicles, but human EVs exhibit significant heterogeneity even in homogeneous cell populations. An antibody-based immunosequencing method enables multiplex measurement of protein molecules from individual EVs, providing a way to detect specific proteins at the single EV level. This technology has the potential to be adapted for multiplexed protein analysis of any nanoparticle.

ACS NANO (2021)

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Article Cell Biology

The emerging role of exosomes in Alzheimer's disease

Tongmei Zhang et al.

Summary: Exosomes, as potential biomarkers and therapeutic targets, play important roles in the pathogenesis, diagnosis, and treatment of Alzheimer's disease. Research findings suggest that exosomal constituents regulate intercellular communication and may offer new avenues for future AD treatments.

AGEING RESEARCH REVIEWS (2021)

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Article Endocrinology & Metabolism

Proteomic Profile of Urinary Extracellular Vesicles Identifies AGP1 as a Potential Biomarker of Primary Aldosteronism

Eric R. Barros et al.

Summary: This study evaluated the proteome of urinary extracellular vesicles (uEVs) from patients with primary aldosteronism (PA) and identified an upregulation of alpha-1-acid glycoprotein 1 (AGP1) in PA uEVs, suggesting AGP1 as a potential biomarker for PA. Additionally, the concentration of uEVs was positively correlated with urinary creatinine, and the size of uEVs in PA patients was smaller compared to the control group, indicating differences in uEV characteristics between the two groups.

ENDOCRINOLOGY (2021)

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Article Biochemical Research Methods

An ultracentrifugation - hollow-fiber flow field-flow fractionation orthogonal approach for the purification and mapping of extracellular vesicle subtypes

Valentina Marassi et al.

Summary: Cells release various vesicles known as extracellular vesicles (EVs) carrying signals for intercellular communication. However, the complex biogenesis and heterogeneity of EVs pose challenges for their characterization and quantification, requiring new combined approaches.

JOURNAL OF CHROMATOGRAPHY A (2021)

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Article Multidisciplinary Sciences

The genetic source tracking of human urinary exosomes

Qingfu Zhu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Genetics & Heredity

Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles

Kathryn A. Jewett et al.

Summary: This study shows that GCase deficiency leads to abnormal protein aggregation within EVs, and restoring GCase protein reduces protein aggregation and affects the spread of protein aggregation between tissues. These findings are important for understanding PD progression and may lead to new targets for slowing neurodegeneration.

PLOS GENETICS (2021)

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Article Biochemistry & Molecular Biology

Circulating Exosomes Are Strongly Involved in SARS-CoV-2 Infection

Elettra Barberis et al.

Summary: Limited knowledge of the host response to SARS-CoV-2 hinders understanding of COVID-19 pathogenesis and therapeutic strategies. This study revealed that SARS-CoV-2 infection modulates exosome content and their involvement in disease progression, highlighting the potential of plasma exosomes as biomarkers for disease severity. Proteomic analysis of patient-derived exosomes identified molecules implicated in immune response, inflammation, coagulation, and complement pathways associated with COVID-19 tissue damage and organ dysfunction. Moreover, the presence of SARS-CoV-2 RNA in exosomes suggests a potential route for viral spread.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Oncology

Proteomic analysis of urinary and tissue-exudative extracellular vesicles to discover novel bladder cancer biomarkers

Eisuke Tomiyama et al.

Summary: Proteomic analysis of urinary EVs combined with Te-EVs allows for selective detection of urinary BCa biomarkers.

CANCER SCIENCE (2021)

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Article Oncology

miRNAs derived from circulating small extracellular vesicles as diagnostic biomarkers for nasopharyngeal carcinoma

Li Jiang et al.

Summary: The study evaluated circulating sEV-derived miRNAs as potential biomarkers for the diagnosis of nasopharyngeal carcinoma (NPC). It identified a distinct set of differentially expressed miRNAs between NPC patients and healthy controls, with target genes mainly involved in cancer-associated signaling pathways. A 3 miRNA-based model showed good discriminating power in diagnosing NPC and had an excellent ability to distinguish NPC patients at different stages from healthy controls.

CANCER SCIENCE (2021)

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Article Neurosciences

Extracellular Vesicles in Serum and Central Nervous System Tissues Contain microRNA Signatures in Sporadic Amyotrophic Lateral Sclerosis

Ting-wen Lo et al.

Summary: ALS is a terminal neurodegenerative disease where pathology may spread in an organized and prion-like manner through extracellular vesicles. The study found differences in size of EVs between ALS patients and healthy controls in spinal cord and serum, as well as altered miRNA levels in ALS frontal cortex, spinal cord, and serum. The dysregulated miRNAs were associated with pathways commonly altered in neurodegeneration, offering potential insights into pathogenic factors of ALS.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

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Article Pharmacology & Pharmacy

Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer's Disease Brain Tissue Reveals Disease-Associated Signatures

Whitaker Cohn et al.

Summary: This study analyzed the composition of EVs derived from microglial cells in the brains of AD patients, revealing significant changes in certain markers in AD EVs compared to normal cases, indicating a potential role for EVs in the progression of AD.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Proteomic and phospholipidomic characterization of extracellular vesicles inducing tumor microenvironment in Epstein-Barr virus-associated lymphomas

Masatoshi Ito et al.

Summary: The study revealed that EVs derived from EBV-transformed lymphomas contain immunomodulatory proteins and phospholipids associated with TAM formation, which may contribute to the development of lymphomas.

FASEB JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Characterization of Extracellular Vesicle Cargo in Sjogren's Syndrome through a SWATH-MS Proteomics Approach

Francesco Finamore et al.

Summary: In this pilot study, SWATH-MS approach was used to monitor extracellular vesicles-enriched saliva sub-proteome in pSS patients, revealing 121 differentially expressed proteins with 82% upregulated and 18% downregulated in pSS samples, mainly related to immune-innate response. The results highlight the usefulness of EVs for discovering novel salivary-omic biomarkers and offer new perspectives for the identification of clinically relevant proteins in pSS.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

A comprehensive study to delineate the role of an extracellular vesicle-associated microRNA-29a in chronic methamphetamine use disorder

Subhash Chand et al.

Summary: The study found that during chronic methamphetamine (MA) exposure, brain-derived EV (BDE) miRNA miR-29a-3p levels significantly increased and were associated with drug-seeking and reinstatement in MA. EV-associated miR-29a was enriched in the EV pool and played a critical role in MA-induced inflammation and synaptodendritic damage. EV-miR29a could potentially serve as a biomarker to detect neuronal damage in MUD individuals.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Cell Biology

Detection of Atherosclerosis by Small RNA-Sequencing Analysis of Extracellular Vesicle Enriched Serum Samples

Alex Hildebrandt et al.

Summary: The study analyzed serum-derived miRNA profiles from patients and volunteers to identify potential biomarkers for atherosclerosis. The differential expression analysis found 27 differentially expressed miRNAs in patients compared to healthy volunteers, with specific miRNA fingerprints for different atherosclerotic manifestations. Overrepresentation analysis revealed relevant biological processes related to atherosclerosis, indicating the potential of these miRNAs as biomarker candidates.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Chemistry, Medicinal

Extracellular Vesicles in Human Milk

Yong Hu et al.

Summary: Milk contains a component called extracellular vesicles (EVs) which have different biological functions in human milk and cow's milk. EVs in human milk expose the protein that triggers blood clotting, while EVs in cow's milk lack this coagulant activity.

PHARMACEUTICALS (2021)

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Article Biochemical Research Methods

Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells

Annalisa L. E. Carli et al.

Summary: DCLK1 is a putative cancer stem cell marker that is associated with advanced disease and poor prognosis in malignant tumors, and has been shown to promote epithelial-to-mesenchymal transition. Additionally, DCLK1 influences the biogenesis of small extracellular vesicles, promoting cell migration and impacting signaling in gastric tumorigenesis.

PROTEOMICS (2021)

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Article Medicine, General & Internal

CD5L as an Extracellular Vesicle-Derived Biomarker for Liquid Biopsy of Lung Cancer

Eun-Sook Choi et al.

Summary: This study focused on analyzing specific molecules within serum-derived extracellular vesicles (EVs) for cancer screening and diagnosis, identifying potential lung cancer biomarkers. The study found that EV-derived CD5L may be a potential biomarker for the noninvasive diagnosis of lung cancer. This discovery provides a promising direction for further research into liquid biopsy-based cancer diagnostics.

DIAGNOSTICS (2021)

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Article Oncology

Extracellular vesicles in the tumor immune microenvironment

Pei-pei Hou et al.

Summary: Extracellular vesicles (EVs) are important mediators of intercellular communication, playing crucial roles in remodeling the tumor immune microenvironment and modulating tumor-specific immunity. Through the mutual communication via EVs, tumor cells and immune cells achieve bidirectional regulation in the TIME.

CANCER LETTERS (2021)

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Article Oncology

Plasma extracellular vesicle microRNA-491-5p as diagnostic and prognostic marker for head and neck squamous cell carcinoma

Wittaya Panvongsa et al.

Summary: The research found that the miRNA prediction model can serve as a blood-based diagnostic marker for LA-HNSCC, and Delta miR-491-5p may be an important monitoring prognostic marker reflecting the survival of HNSCC patients.

CANCER SCIENCE (2021)

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Article Biochemistry & Molecular Biology

MicroRNA-431-5p encapsulated in serum extracellular vesicles as a biomarker for proliferative diabetic retinopathy

Bo Yu et al.

Summary: Early diagnosis and precise monitoring of PDR are crucial for improving therapeutic strategies and reducing blindness. EVs, especially sEVs, are potential sources for novel biomarkers, with miR-431-5p showing promise as a biomarker for PDR.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2021)

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Article Cell Biology

Identification and characterization of hADSC-derived exosome proteins from different isolation methods

Lien-Hung Huang et al.

Summary: Exosomes are secreted by many cell types and play roles in various biological processes. Adipose-derived mesenchymal stem cells (ADSCs) can secrete paracrine factors through exosomes, with potential diagnostic and therapeutic applications. Different isolation methods may introduce variations in exosome protein composition, affecting their biological function.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Review Nanoscience & Nanotechnology

Extracellular vesicles as a next-generation drug delivery platform

Inge Katrin Herrmann et al.

Summary: Extracellular vesicles play a crucial role in cell-to-cell communication and can serve as drug carriers with advantages over synthetic carriers. However, clinical translation of extracellular vesicle-based therapies remains challenging, requiring further research and development efforts.

NATURE NANOTECHNOLOGY (2021)

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Article Neurosciences

Proteome profiling of neuron-derived exosomes in Alzheimer's disease reveals hemoglobin as a potential biomarker

Burak Ibrahim Arioz et al.

Summary: Alzheimer's disease is a chronic neurodegenerative disorder with limited diagnostic methods. This study found that hemoglobin levels were elevated in neuron-derived exosomes of AD patients, suggesting it could be a diagnostic marker for the disease.

NEUROSCIENCE LETTERS (2021)

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Article Multidisciplinary Sciences

Shotgun-based proteomics of extracellular vesicles in Alzheimer's disease reveals biomarkers involved in immunological and coagulation pathways

Jonas Ellegaard Nielsen et al.

Summary: Alzheimer's disease (AD) is the most common form of dementia with no readily available clinical biomarkers. Blood-derived extracellular vesicles (EVs) show potential as a source for AD biomarkers, with specific proteins elevated in some AD patients. Certain proteins can effectively distinguish between AD patients and healthy controls, indicating that EVs provide a promising and accessible matrix for AD biomarkers.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Extracellular vesicle-shuttled miRNAs as a diagnostic and prognostic biomarker and their potential roles in gallbladder cancer patients

Eijiro Ueta et al.

Summary: The study found that miR-1246 in serum extracellular vesicles (EVs) may serve as a diagnostic and prognostic marker for gallbladder cancer (GBC), while miR-451a could be a novel therapeutic target for GBC. Additionally, through analyzing the functional roles of miRNAs, the study also revealed the regulatory effects of miR-1246 and miR-451a on proliferation, invasion, and apoptosis in GBC cell lines.

SCIENTIFIC REPORTS (2021)

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Article Oncology

Exploration of the Proteomic Landscape of Small Extracellular Vesicles in Serum as Biomarkers for Early Detection of Colorectal Neoplasia

Li-Chun Chang et al.

Summary: It was found that patients with colorectal neoplasia had a distinct sEV proteome expression pattern in serum compared to healthy individuals, and six specific sEV proteins were identified to differentiate early-stage from advanced neoplasia. Additionally, the study explored the implication of the sEV proteome in colorectal cancer carcinogenesis via specific signaling pathways.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

A Novel Microfluidic Chip for Fast, Sensitive Quantification of Plasma Extracellular Vesicles as Biomarkers in Patients With Osteosarcoma

Yi-Qi Xu et al.

Summary: Utilizing the ZnO-nanorods integrated microfluidic chip facilitates rapid and efficient capture of plasma EVs, showing great potential as a reliable diagnostic and surveillance tool in osteosarcoma.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell Biology

Early prediction of COVID-19 severity using extracellular vesicle COPS2

Yu Fujita et al.

Summary: The study identified EV COPB2 protein as a potential early predictive biomarker for severity of COVID-19, showing excellent predictive value in both discovery and validation cohorts.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Cell Biology

Establishment of a simplified dichotomic size-exclusion chromatography for isolating extracellular vesicles toward clinical applications

Jiahui Guo et al.

Summary: The study established a simplified SEC method and compared different resins for EV isolation. By increasing column bed volumes and optimizing operations, the resolution and purity of EVs were improved. A dichotomic SEC method requiring only two bulk elutions was developed for efficient EV and protein separation from complex samples.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Cell Biology

Extracellular vesicle miRNA predict FDG-PET status in patients with classical Hodgkin Lymphoma

Esther E. E. Drees et al.

Summary: This study showed that miRNAs associated with tumour-secreted EVs in the circulation of cHL patients can improve response assessment. The levels of EV-miRNAs are predictive of metabolic tumour activity in cHL patients, and combining them with TARC protein levels increases the accuracy for predicting PET-status.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Medicine, Research & Experimental

Extracellular Vesicle Proteome of Breast Cancer Patients with and Without Cognitive Impairment Following Anthracycline-based Chemotherapy: An Exploratory Study

Yong Qin Koh et al.

Summary: The study identified 517 differentially expressed EV proteins between cognitive impaired and non-impaired groups, suggesting a potential link between cognitive impairment and alterations in synaptic plasticity mechanisms. Additionally, reduced tight junction proteins in EVs of cognitive-impaired patients may indicate a weakening of the blood-brain barrier. These EV protein signatures could serve as a fingerprint for understanding the mechanisms underlying cognitive impairment in cancer patients and survivors.

BIOMARKER INSIGHTS (2021)

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Article Biochemical Research Methods

Isolation and quantification of extracellular vesicle-encapsulated microRNA on an integrated microfluidic platform

Chia-Yu Sung et al.

Summary: The study developed an integrated microfluidic platform for isolating and quantifying ovarian cancer blood biomarkers, demonstrating high sensitivity and accuracy. The system showed promising potential as a valuable tool for ovarian cancer biomarker measurements.

LAB ON A CHIP (2021)

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Article Biochemistry & Molecular Biology

Extracellular Vesicle Separation Techniques Impact Results from Human Blood Samples: Considerations for Diagnostic Applications

Theophilos Tzaridis et al.

Summary: Extracellular vesicles (EVs) are valuable sources of biomarkers, but their clinical use requires simple, comparable, and reproducible analytical methods. A comprehensive analysis of EV separation techniques found that combining size exclusion chromatography (SEC) with ultracentrifugation yields the highest purity and functionality of EVs for biomarker studies from human serum or plasma.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Integrative Multi-Omics Approaches in Cancer Research: From Biological Networks to Clinical Subtypes

Yong Jin Heo et al.

Summary: Multi-omics approaches integrate multiple omics datasets to better understand cancer, classify cancers into subtypes, improve survival prediction and therapeutic outcome, and understand key pathophysiological processes. Emerging omics algorithms provide unprecedented opportunities in cancer research, leading to advancements in patient subtyping and drug development. Large-scale multi-omics studies have significant implications for improving cancer treatment and patient outcomes.

MOLECULES AND CELLS (2021)

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Article Chemistry, Multidisciplinary

Metabolomic analysis of exosomal-markers in esophageal squamous cell carcinoma

Qingfu Zhu et al.

Summary: Metabolomic analysis of plasma exosomes in patients with ESCC revealed 196 metabolites, with a marker set of 3'-UMP, palmitoleic acid, palmitaldehyde, and isobutyl decanoate showing high accuracy in predicting ESCC recurrence. These exosome metabolome signatures, likely associated with cancer metabolism, could potentially serve as novel biomarkers for diagnosis and prognosis of ESCC.

NANOSCALE (2021)

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Article Nanoscience & Nanotechnology

Isolation of Exosome Nanoparticles from Human Cerebrospinal Fluid for Proteomic Analysis

Meng Li et al.

Summary: A label-free method was developed to rapidly isolate exosomes from cerebrospinal fluid for proteomic analysis, showing higher yield and purity compared to traditional methods. Proteomic analysis revealed that the exosomes isolated by this method identified more exosome-related proteins, potentially reflecting disease status for exosome-based diagnosis.

ACS APPLIED NANO MATERIALS (2021)

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Article Medicine, Research & Experimental

Discovery of extracellular vesicles derived miR-181a-5p in patient's serum as an indicator for bone-metastatic prostate cancer

Yanqing Wang et al.

Summary: The study identified miR-181a-5p as a potential diagnostic biomarker for bone-metastatic prostate cancer in EVs from patient's serum, with significantly upregulated expression in bone metastatic groups compared to non-bone metastatic groups. Logistic regression and AUC analysis confirmed miR-181a-5p as the best biomarker for diagnosing both prostate cancer and bone metastatic prostate cancer.

THERANOSTICS (2021)

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Article Oncology

Circulating extracellular vesicle-encapsulated HULC is a potential biomarker for human pancreatic cancer

Kenji Takahashi et al.

CANCER SCIENCE (2020)

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Article Biochemical Research Methods

Potential urinary extracellular vesicle protein biomarkers of chronic active antibody-mediated rejection in kidney transplant recipients

Hee-Yeon Jung et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2020)

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Review Biochemical Research Methods

From laboratory to clinic: Translation of extracellular vesicle based cancer biomarkers

Anudeep Yekula et al.

METHODS (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Article Physiology

Extracellular vesicle miRNA-21 is a potential biomarker for predicting chronic lung disease in premature infants

Hayato Go et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2020)

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Article Oncology

Predicting the presence of breast cancer using circulating small RNAs, including those in the extracellular vesicles

Yumiko Koi et al.

CANCER SCIENCE (2020)

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Review Immunology

The function and clinical application of extracellular vesicles in innate immune regulation

Xiaoxue Zhou et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Article Clinical Neurology

Serum neuronal exosomes predict and differentiate Parkinson's disease from atypical parkinsonism

Cheng Jiang et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2020)

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Article Biochemical Research Methods

Comparative Glycomic Analysis of Exosome Subpopulations Derived from Pancreatic Cancer Cell Lines

Atsushi Matsuda et al.

JOURNAL OF PROTEOME RESEARCH (2020)

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Review Immunology

Post-translational Modification Regulates Formation and Cargo-Loading of Extracellular Vesicles

Jonathan M. Carnino et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Oncology

Hypoxia-Induced Adaptations of miRNomes and Proteomes in Melanoma Cells and Their Secreted Extracellular Vesicles

Geoffroy Walbrecq et al.

CANCERS (2020)

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Article Chemistry, Analytical

Deconstruction of Heterogeneity of Size-Dependent Exosome Subpopulations from Human Urine by Profiling N-Glycoproteomics and Phosphoproteomics Simultaneously

Haoyang Zheng et al.

ANALYTICAL CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

Ayuko Hoshino et al.

CELL (2020)

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Article Biochemistry & Molecular Biology

Deep Sequencing of Small RNAs from Neurosurgical Extracellular Vesicles Substantiates miR-486-3p as a Circulating Biomarker that Distinguishes Glioblastoma from Lower-Grade Astrocytoma Patients

Susannah Hallal et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

Revealing the Proteome of Motor Cortex Derived Extracellular Vesicles Isolated from Amyotrophic Lateral Sclerosis Human Postmortem Tissues

Natasha Vassileff et al.

CELLS (2020)

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Article Biochemistry & Molecular Biology

Mass-Spectrometry Based Proteome Comparison of Extracellular Vesicle Isolation Methods: Comparison of ME-kit, Size-Exclusion Chromatography, and High-Speed Centrifugation

Anders Askeland et al.

BIOMEDICINES (2020)

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Review Engineering, Biomedical

Exosomes as a next-generation drug delivery system: An update on drug loading approaches, characterization, and clinical application challenges

Fatemeh Mehryab et al.

ACTA BIOMATERIALIA (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Tracking of Tumor Cell-Derived Extracellular VesiclesIn VivoReveals a Specific Distribution Pattern with Consecutive Biological Effects on Target Sites of Metastasis

Mirjam Gerwing et al.

MOLECULAR IMAGING AND BIOLOGY (2020)

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Article Oncology

Serum small extracellular vesicle-derivedLINC00853as a novel diagnostic marker for early hepatocellular carcinoma

Soon Sun Kim et al.

MOLECULAR ONCOLOGY (2020)

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Article Virology

Extracellular vesicles in virus infection and pathogenesis

Ryan P. McNamara et al.

CURRENT OPINION IN VIROLOGY (2020)

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Article Biochemical Research Methods

CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis

Alexander G. Thompson et al.

CLINICAL PROTEOMICS (2020)

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Article Cell Biology

Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study

Satoshi Muraoka et al.

CELLS (2020)

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Review Immunology

Extracellular Vesicles in Viral Infections: Two Sides of the Same Coin?

Sharon de Toledo Martins et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Application of exosomes as liquid biopsy in clinical diagnosis

Biting Zhou et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Cell Biology

A circulating extracellular vesicles-based novel screening tool for colorectal cancer revealed by shotgun and data-independent acquisition mass spectrometry

Xi Zheng et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Review Biology

Apoptotic Bodies: Particular Extracellular Vesicles Involved in Intercellular Communication

Michela Battistelli et al.

BIOLOGY-BASEL (2020)

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Article Medicine, Research & Experimental

Extracellular vesicle-mediated delivery of miR-101 inhibits lung metastasis in osteosarcoma

Kailiang Zhang et al.

THERANOSTICS (2020)

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Article Biochemical Research Methods

Asymmetric-flow field-flow fractionation technology for exomere and small extracellular vesicle separation and characterization

Haiying Zhang et al.

NATURE PROTOCOLS (2019)

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Article Biochemistry & Molecular Biology

Reassessment of Exosome Composition

Dennis K. Jeppesen et al.

CELL (2019)

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Review Biochemistry & Molecular Biology

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

Ladan Mashouri et al.

MOLECULAR CANCER (2019)

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Small RNA-sequence analysis of plasma-derived extracellular vesicle miRNAs in smokers and patients with chronic obstructive pulmonary disease as circulating biomarkers

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Plasmatic extracellular vesicle microRNAs in malignant pleural mesothelioma and asbestos-exposed subjects suggest a 2-miRNA signature as potential biomarker of disease

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Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics

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Differential protein profiling of renal cell carcinoma urinary exosomes

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Extracellular vesicle-mediated transfer of donor genomic DNA to recipient cells is a novel mechanism for genetic influence between cells

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Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-β1

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Isolation and identification of potential urinary microparticle biomarkers of bladder cancer

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