☆ 4.5 Review

Trends in mechanobiology guided tissue engineering and tools to study cell-substrate interactions: a brief review

BIOMATERIALS RESEARCH (2023)

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Summary: This study investigates the differentiation of human bone-marrow-derived mesenchymal stem cells (hBMSCs) into early osteoblasts on a remarkably soft 3D hydrogel. Pulsatile pressure stimulation (PPS) of 5-20 kPa for 7 days stimulates cellular processes such as mechanotransduction, cytoskeletal distribution, calcium homeostasis, and osteogenic marker gene expression. The involvement of Piezo 1 in mechanotransduction is identified as the main ion channel. RNA-sequencing results reveal differential gene expression related to osteogenesis, bone mineralization, ion channel activity, and focal adhesion.

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Berna Ozkale et al.

Summary: Active biomaterials offer novel approaches to study mechanotransduction in mammalian cells by probing cellular responses through dynamic modulation of resistance to forces and application of external forces in a controlled manner. These biomaterials have generated scientific knowledge and therapeutic potential in various conditions, including cancer metastasis, fibrosis, and tissue regeneration. Recent advances in active biomaterials have shed light on a repertoire of cellular responses that can be studied, with implications for future impact.

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Controllable ligand spacing stimulates cellular mechanotransduction and promotes stem cell osteogenic differentiation on soft hydrogels

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Myoblast mechanotransduction and myotube morphology is dependent on BAG3 regulation of YAP and TAZ

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Stiffness of Nanoparticulate Mineralized Collagen Scaffolds Triggers Osteogenesis via Mechanotransduction and Canonical Wnt Signaling

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Micro/nanoengineered technologies for human pluripotent stem cells maintenance and differentiation

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Moritz Hofer et al.

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Simple yet effective methods to probe hydrogel stiffness for mechanobiology

Alessandro Gandin et al.

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Etienne de Coulon et al.

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Anya B. Roberts et al.

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Di Li et al.

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Liliana Barbieri et al.

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NATURE COMMUNICATIONS (2021)

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Veronika Pfannenstill et al.

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Viscoelasticity and Adhesion Signaling in Biomaterials Control Human Pluripotent Stem Cell Morphogenesis in 3D Culture

Dhiraj Indana et al.

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Innovative Tools for Mechanobiology: Unraveling Outside-In and Inside-Out Mechanotransduction

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FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

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Brillouin microscopy: an emerging tool for mechanobiology

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NATURE METHODS (2019)

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Soft Hyaluronic Gels Promote Cell Spreading, Stress Fibers, Focal Adhesion, and Membrane Tension by Phosphoinositide Signaling, Not Traction Force

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ACS NANO (2019)

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Biomaterials for In Situ Tissue Regeneration: A Review

Saba Abdulghani et al.

BIOMOLECULES (2019)

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Review Chemistry, Physical

Encapsulation of the cytoskeleton: towards mimicking the mechanics of a cell

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SOFT MATTER (2019)

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Mapping the creep compliance of living cells with scanning ion conductance microscopy reveals a subcellular correlation between stiffness and fluidity

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NANOSCALE (2019)

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Atomic force microscopy-based mechanobiology

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NATURE REVIEWS PHYSICS (2019)

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Cell-Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research

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Non-contact mechanical and chemical analysis of single living cells by microspectroscopic techniques

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In Situ Real-Time Mechanical and Morphological Characterization of Electrodes for Electrochemical Energy Storage and Conversion by Electrochemical Quartz Crystal Microbalance with Dissipation Monitoring

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ACCOUNTS OF CHEMICAL RESEARCH (2018)

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ACCOUNTS OF CHEMICAL RESEARCH (2018)

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Nanoscaled and microscaled parallel topography promotes tenogenic differentiation of ASC and neotendon formation in vitro

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Quantitative characterization of viscoelastic behavior in tissue-mimicking phantoms and ex vivo animal tissues

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PLOS ONE (2018)

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Generation of Neural Organoids from Human Embryonic Stem Cells Using the Rotary Cell Culture System: Effects of Microgravity on Neural Progenitor Cell Fate

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STEM CELLS AND DEVELOPMENT (2018)

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Moshabab A. Asiry

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Real-time QCM-D monitoring of endothelial cells and macrophages adhering and spreading to SEMA4D/heparin surfaces

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Multiplexed protein maps link subcellular organization to cellular states

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SCIENCE (2018)

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Native-mimicking in vitro microenvironment: an elusive and seductive future for tumor modeling and tissue engineering

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CELLS (2018)

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Editorial Material Biochemistry & Molecular Biology

Optical Tweezers: A Force to Be Reckoned With

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Three-Dimensional Nanostructured Architectures Enable Efficient Neural Differentiation of Mesenchymal Stem Cells via Mechanotransduction

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Acoustic tweezers for the life sciences

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Mechanobiology: protein refolding under force

Lonel Popa et al.

EMERGING TOPICS IN LIFE SCIENCES (2018)

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The future of traction force microscopy

Huw Colin-York et al.

CURRENT OPINION IN BIOMEDICAL ENGINEERING (2018)

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Review Biotechnology & Applied Microbiology

Quartz Crystal Microbalance With Dissipation Monitoring: A Powerful Method to Predict the in vivo Behavior of Bioengineered Surfaces

Chiara Tonda-Turo et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2018)

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Effect of Surface Potential on the Adhesion Behavior of NIH3T3 Cells Revealed by Quartz Crystal Microbalance with Dissipation Monitoring (QCM-D)

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JOURNAL OF PHYSICAL CHEMISTRY C (2017)

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Dissection of mechanical force in living cells by super-resolved traction force microscopy

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NATURE PROTOCOLS (2017)

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Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels

William J. Hadden et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Dynamically tunable cell culture platforms for tissue engineering and mechanobiology

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PROGRESS IN POLYMER SCIENCE (2017)

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Cell Microarray Technologies for High-Throughput Cell-Based Biosensors

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SENSORS (2017)

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A multiplexed magnetic tweezer with precision particle tracking and bi-directional force control

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CYCLIC TENSILE STRAIN ENHANCES HUMAN MESENCHYMAL STEM CELL SMAD 2/3 ACTIVATION AND TENOGENIC DIFFERENTIATION IN ANISOTROPIC COLLAGEN-GLYCOSAMINOGLYCAN SCAFFOLDS

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The Osteogenic and Tenogenic Differentiation Potential of C3H10T1/2 (Mesenchymal Stem Cell Model) Cultured on PCL/PLA Electrospun Scaffolds in the Absence of Specific Differentiation Medium

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Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores

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A microengineered collagen scaffold for generating a polarized crypt-villus architecture of human small intestinal epithelium

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Estimation of Viscoelastic Properties of Cells Using Acoustic Tweezing Cytometry

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Super-Resolved Traction Force Microscopy (STFM)

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NANO LETTERS (2016)

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Nanowire Arrays as Cell Force Sensors To Investigate Adhesin-Enhanced Holdfast of Single Cell Bacteria and Biofilm Stability

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Designer matrices for intestinal stem cell and organoid culture

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Mechanotransduction of Neural Cells Through Cell-Substrate Interactions

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Microenvironmental Control of Adipocyte Fate and Function

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TRENDS IN CELL BIOLOGY (2016)

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Aligned multilayered electrospun scaffolds for rotator cuff tendon tissue engineering

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ACTA BIOMATERIALIA (2015)

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A guide to mechanobiology: Where biology and physics meet

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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2015)

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Combinatorial polymer matrices enhance in vitro maturation of human induced pluripotent stem cell-derived cardiomyocytes

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Enhanced efficiency of genetic programming toward cardiomyocyte creation through topographical cues

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Micro- and nanodevices integrated with biomolecular probes

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BIOTECHNOLOGY ADVANCES (2015)

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Resolving Intra- and Inter-Molecular Structure with Non-Contact Atomic Force Microscopy

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

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Review Cell & Tissue Engineering

Concise Review: Growing Hearts in the Right Place: On the Design of Biomimetic Materials for Cardiac Stem Cell Differentiation

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STEM CELLS (2015)

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Article Multidisciplinary Sciences

Controlling cell-cell interactions using surface acoustic waves

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Directing Stem Cell Differentiation by Changing the Molecular Mobility of Supramolecular Surfaces

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ADVANCED HEALTHCARE MATERIALS (2015)

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Temporal impact of substrate mechanics on differentiation of human embryonic stem cells to cardiomyocytes

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ACTA BIOMATERIALIA (2014)

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Nanopatterned muscle cell patches for enhanced myogenesis and dystrophin expression In a mouse model of muscular dystrophy

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BIOMATERIALS (2014)

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Three-dimensional traction forces of Schwann cells on compliant substrates

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JOURNAL OF THE ROYAL SOCIETY INTERFACE (2014)

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Electrospun fibre diameter, not alignment, affects mesenchymal stem cell differentiation into the tendon/ligament lineage

Robyn D. Cardwell et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2014)

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Interplay of matrix stiffness and protein tethering in stem cell differentiation

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NATURE MATERIALS (2014)

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High Resolution, Large Deformation 3D Traction Force Microscopy

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PLOS ONE (2014)

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Nanotopographical Manipulation of Focal Adhesion Formation for Enhanced Differentiation of Human Neural Stem Cells

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ACS APPLIED MATERIALS & INTERFACES (2013)

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Lower Extent but Similar Rhythm of Osteogenic Behavior in hBMSCs Cultured on Nanofibrous Scaffolds versus Induced with Osteogenic Supplement

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Osteogenesis of Mesenchymal Stem Cells by Nanoscale Mechanotransduction

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ACS NANO (2013)

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Substrate topography and size determine the fate of human embryonic stem cells to neuronal or glial lineage

Soneela Ankam et al.

ACTA BIOMATERIALIA (2013)

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Mesenchymal stem cells ability to generate traction stress in response to substrate stiffness is modulated by the changing extracellular matrix composition of the heart during development

Joshua R. Gershlak et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

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The effect of microgrooved culture substrates on calcium cycling of cardiac myocytes derived from human induced pluripotent stem cells

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BIOMATERIALS (2013)

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Stimulation of adipogenesis of adult adipose-derived stem cells using substrates that mimic the stiffness of adipose tissue

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BIOMATERIALS (2013)

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Review Oncology

Toward single cell traction microscopy within 3D collagen matrices

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EXPERIMENTAL CELL RESEARCH (2013)

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Biophysical regulation of epigenetic state and cell reprogramming

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NATURE MATERIALS (2013)

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Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions

Wesley R. Legant et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Aligned Fibrous Scaffolds for Enhanced Mechanoresponse and Tenogenesis of Mesenchymal Stem Cells

Thomas K. H. Teh et al.

TISSUE ENGINEERING PART A (2013)

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Acoustic tweezing cytometry for live-cell subcellular modulation of intracellular cytoskeleton contractility

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SCIENTIFIC REPORTS (2013)

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Tenogenic differentiation of human bone marrow stem cells via a combinatory effect of aligned chitosan-polycaprolactone nanofibers and TGF-beta 3

Matthew Leung et al.

JOURNAL OF MATERIALS CHEMISTRY B (2013)

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Article Engineering, Biomedical

A micropatterning and image processing approach to simplify measurement of cellular traction forces

Samuel R. Polio et al.

ACTA BIOMATERIALIA (2012)

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The differential effects of aligned electrospun PHBHHx fibers on adipogenic and osteogenic potential of MSCs through the regulation of PPAR gamma signaling

Yang Wang et al.

BIOMATERIALS (2012)

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Routine and Timely Sub-picoNewton Force Stability and Precision for Biological Applications of Atomic Force Microscopy

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NANO LETTERS (2012)

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Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics

Murat Guvendiren et al.

NATURE COMMUNICATIONS (2012)

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Mechanosignaling to the Cell Nucleus and Gene Regulation

G. V. Shivashankar

ANNUAL REVIEW OF BIOPHYSICS, VOL 40 (2011)

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Matrix Stiffness Regulation of Integrin-Mediated Mechanotransduction During Osteogenic Differentiation of Human Mesenchymal Stem Cells

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JOURNAL OF BONE AND MINERAL RESEARCH (2011)

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MEMS sensors and microsystems for cell mechanobiology

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JOURNAL OF MICROMECHANICS AND MICROENGINEERING (2011)

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The effect of poly (L-lactic acid) nanofiber orientation on osteogenic responses of human osteoblast-like MG63 cells

Bo Wang et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2011)

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Assaying stem cell mechanobiology on microfabricated elastomeric substrates with geometrically modulated rigidity

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NATURE PROTOCOLS (2011)

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Unidirectional mechanical cellular stimuli via micropost array gradients

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SOFT MATTER (2011)

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The use of decellularized adipose tissue to provide an inductive microenvironment for the adipogenic differentiation of human adipose-derived stem cells

L. E. Flynn

BIOMATERIALS (2010)

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The effect of nanofiber-guided cell alignment on the preferential differentiation of neural stem cells

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BIOMATERIALS (2010)

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The regulation of tendon stem cell differentiation by the alignment of nanofibers

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Micropatterned matrix directs differentiation of human mesenchymal stem cells towards myocardial lineage

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EXPERIMENTAL CELL RESEARCH (2010)

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Mechanobiology of cardiomyocyte development

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Mechanobiology of bone healing and regeneration: in vivo models

D. R. Epari et al.

PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE (2010)

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Mechanotransduction in development: a growing role for contractility

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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)

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Induction of osteoblast differentiation phenotype on poly(L-lactic acid) nanofibrous matrix

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BIOMATERIALS (2008)

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A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ

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FEBS JOURNAL (2008)

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The role of matrix stiffness in regulating cell behavior

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HEPATOLOGY (2008)

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Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating

Adam J. Engler et al.

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Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage

Evelyn K. F. Yim et al.

EXPERIMENTAL CELL RESEARCH (2007)

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Adipogenesis of murine embryonic stem cells in a three-dimensional culture system using electrospun polymer scaffolds

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BIOMATERIALS (2007)

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Force sensing by mechanical extension of the Src family kinase substrate p130Cas

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CELL (2006)

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Matrix elasticity directs stem cell lineage specification

Adam J. Engler et al.

CELL (2006)

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Tissue regeneration - The past, the present and the future

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INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2005)

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Article Biochemistry & Molecular Biology

Neuronal sodium channels in ventricular heart cells are localized near T-tubules openings

H Duclohier

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

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Changes in integrin expression during adipocyte differentiation

J Liu et al.

CELL METABOLISM (2005)

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The emergence of integrins: a personal and historical perspective

RO Hynes

MATRIX BIOLOGY (2004)

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Article Cell Biology

Myotubes differentiate optimally on substrates with tissue-like stiffness:: pathological implications for soft or stiff microenvironments

AJ Engler et al.

JOURNAL OF CELL BIOLOGY (2004)

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Article Biochemical Research Methods

Simultaneous, real-time imaging of intracellular calcium and cellular traction force production

AD Doyle et al.

BIOTECHNIQUES (2002)

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Traction fields, moments, and strain energy that cells exert on their surroundings

JP Butler et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2002)

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Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates

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NATURE CELL BIOLOGY (2001)

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Regulating cellular actin assembly

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CURRENT OPINION IN CELL BIOLOGY (2001)

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Cellular function of p70S6K:: A role in regulating cell motility

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IMMUNOLOGY AND CELL BIOLOGY (2000)

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