Association of Internal and External Motion Based on Cine MR Images Acquired During Real-Time Treatment on MRI-Guided Linear Accelerator for Patients With Lung Cancer

Purpose: With the recent clinical implementation of magnetic resonance imaging (MRI)-guided linear accelerators, a large number of real-time planar MR images has been acquired during lung cancer treatment as a standard of care. In this study, associations among lung tumor, diaphragm, and external skin movement were studied based on MR cine imaging during the entire duration of each treatment fraction.Methods and materials: This retrospective study used 181,798 planar MRI frames acquired over 55 treatment/imaging sessions of 13 patients with lung cancer treated on 2 MRI-guided linear accelerators. From each planar MR image frame, in-house software automatically extracted 9 features: the superior-interior (SI) and posterior-anterior (PA) positions of a lung tumor; the area of the lung (Lung_Area); the posterior (Dia_Post), dome/apex (Dia_Dome), and anterior (Dia_Ant) points of a diaphragmatic curve; the diaphragm curve point (Dia_Max); and the chest (Chest) and belly (Belly) skin points experienced the maximum range of motions. Correlation analyses were performed among the 9 features for every session. Lung tumor motion range and standard deviations were calculated based on positions obtained in cine images and compared with motion ranges obtained from 4-dimensional computed tomography images.Results: In the study, 177,009 frames of images were successfully analyzed. For all patients, correlation coefficients were as follows: 0.91 +/- 0.10 between any 2 features among Lung_Area, Dia_Post, Dia_Dome, and Dia_Max; 0.82 +/- 0.21 between SI and any feature among Lung_Area, Dia_Post, Dia_Dome, and Dia_Max; 0.75 +/- 0.24 between SI and Belly. Six of 13 patients were considered large amplitude motion (patients with lung tumor SI motion standard deviation >5 mm). Furthermore, 92,956 frames of images were analyzed for the 6 large-amplitude motion patients. For this set, correlation coefficients were 0.93 +/- 0.07 between any 2 features among Lung_Area, Dia_Post, Dia_Dome, and Dia_Max; 0.94 +/- 0.06 between SI and any feature among Lung_Area, Dia_Post, Dia_Dome, and Dia_Max; and 0.90 +/- 0.09 between SI and Belly.Conclusions: Both belly and diaphragmatic motions as assessed by cine MRI are highly correlated with large amplitude lung tumor motion in the longitudinal axis.(c) 2023 Published by Elsevier Inc. on behalf of American Society for Radiation Oncology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Automated summary

This study investigated the association between lung tumor, diaphragm, and external skin movement during lung cancer treatment using MR cine imaging. The results showed a strong correlation between belly and diaphragmatic motions and large amplitude lung tumor motion in the longitudinal axis.