☆ 3.8 Editorial Material

Acute liver injury induces expression of FGF23 in hepatocytes via orphan nuclear receptor ERRg signaling

GENES & DISEASES (2023)

Mouse liver injury induces hepatic macrophage FGF23 production

Pradeep Kumar et al.

Summary: It has been discovered that FGF23, which is originally associated with renal disease, is also linked to hepatic and cardiac diseases. The liver is found to produce FGF23 in response to injury and it may have proinflammatory effects on hepatocytes and other organs.

PLOS ONE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Systemic Jak1 activation provokes hepatic inflammation and imbalanced FGF23 production and cleavage

Arezoo Daryadel et al.

Summary: Activation of the Jak1/Stat3 signaling pathway leads to liver inflammation and increased hepatic FGF23 synthesis, causing imbalance and blocking phosphaturic activity. Despite elevated active FGF23 levels, kidney function remains normal and MAPK pathway activation is not detected.

FASEB JOURNAL (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Orphan nuclear receptor ERR-γ regulates hepatic FGF23 production in acute kidney injury

Kamalakannan Radhakrishnan et al.

Summary: The study showed a link between high circulating FGF23 levels and disease progression and mortality in acute kidney injury patients. Through research in FA-induced AKI mice, it was discovered that IL-6 and ERR-gamma regulate the production of FGF23 in the liver, with an inverse agonist of ERR-gamma potentially serving as a therapeutic strategy to reduce adverse plasma FGF23 levels in AKI.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Pediatrics

Two Case Reports of FGF23-Induced Hypophosphatemia in Childhood Biliary Atresia

Halley Wasserman et al.

PEDIATRICS (2016)

添加到收藏夹

Review Biotechnology & Applied Microbiology

FGF23 in Acute and Chronic Illness

Christian Schnedl et al.

DISEASE MARKERS (2015)

添加到收藏夹

Acute liver injury induces expression of FGF23 in hepatocytes via orphan nuclear receptor ERRg signaling

相关参考文献

Mouse liver injury induces hepatic macrophage FGF23 production

Systemic Jak1 activation provokes hepatic inflammation and imbalanced FGF23 production and cleavage

Orphan nuclear receptor ERR-γ regulates hepatic FGF23 production in acute kidney injury

Two Case Reports of FGF23-Induced Hypophosphatemia in Childhood Biliary Atresia

FGF23 in Acute and Chronic Illness

导出引文

分享论文