3.8 Review

Molecular and cellular pathophysiology of circulating cardiomyocyte-specific cell free DNA (cfDNA): Biomarkers of heart failure and potential therapeutic targets

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

Oxidized mitochondrial DNA sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine

Chunju Fang et al.

Summary: The study demonstrates that oxidized mitochondrial DNA and STING signaling play key roles in enhancing the antitumor effect of an irradiated tumor cell vaccine. Elevated levels of ROS and oxidized mtDNA in irradiated tumor cells activate the STING-TBK1-IRF3-IFN-beta pathway in dendritic cells, leading to antitumor immunity.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Editorial Material Cardiac & Cardiovascular Systems

Circulating cell-free DNA levels are associated with adverse outcomes in heart failure: testing liquid biopsy in heart failure

Andrea Salzano et al.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Autocrine Signaling in Cardiac Remodeling: A Rich Source of Therapeutic Targets

Vincent F. M. Segers et al.

Summary: The myocardium is composed of different cell types, including endothelial cells, cardiomyocytes, and fibroblasts, and communication between these cells is crucial for normal cardiac function. Studies have shown that many ligand-receptor pairs are present in most heart cells, indicating that autocrine signaling is a widespread phenomenon in cardiac remodeling and heart failure. Autocrine signaling is involved in various pathophysiological mechanisms observed in myocardial biology and disease, highlighting its essential role in heart health.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Article Hematology

Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease

Laxminath Tumburu et al.

Summary: Sickle cell disease is driven by chronic inflammation associated with elevated cell-free DNA, specifically mitochondrial DNA, in patients. The abnormal retention of mitochondria in circulating red blood cells of patients contributes to the increased levels of cf-mtDNA. High levels of cf-mtDNA in patient plasma trigger the formation of neutrophil extracellular traps, implicating activation of the cGAS-STING pathway.
Review Cell Biology

Sensing and Responding of Cardiomyocytes to Changes of Tissue Stiffness in the Diseased Heart

Juliane Muench et al.

Summary: Cardiomyocytes are exposed to mechanical stimulation due to cardiac contractility, with changes in myocardial stiffness affecting ventricular compliance and blood filling, leading to heart disease. Recent research has shown how disease-related environmental stiffness changes impact cardiomyocyte behavior and function.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Cardiac & Cardiovascular Systems

Pathophysiology of heart failure

Robert H. G. Schwinger

Summary: Heart failure is a global epidemic disease that affects about 1% to 2% of the population worldwide, with varying etiology and phenotype. Various cellular, structural, and neurohumoral modulations occur after a cardiac injury, leading to a complex pathophysiology involving activation of different systems and the need for personalized diagnostic and therapeutic approaches.

CARDIOVASCULAR DIAGNOSIS AND THERAPY (2021)

Review Cardiac & Cardiovascular Systems

Cell-free DNA beyond a biomarker for rejection: Biological trigger of tissue injury and potential therapeutics

Naoko Tsuji et al.

Summary: Cell-free DNA, measured as donor-derived cell-free DNA, is being developed as a non-specific biomarker for allograft injury and transplant rejection. However, the characteristics of cell-free DNA are more specific and can be used to phenotype transplant rejection and point to underlying molecular mechanisms. Novel treatment approaches targeting these cell-free DNA pathways may be useful in treating rejection and preventing organ dysfunction.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2021)

Review Genetics & Heredity

The Nexus of cfDNA and Nuclease Biology

Diana S. C. Han et al.

Summary: Cell-free DNA (cfDNA) serves as a widely used noninvasive biomarker in the diagnosis and prognosis of diseases. The balance between cfDNA generation and clearance is crucial in maintaining health and managing diseases, with plasma nuclease activity linked to various pathologies and changes in cfDNA fragmentation. Further research on factors influencing cfDNA levels and fragmentomic profiles provides insights into the biology of cfDNA.

TRENDS IN GENETICS (2021)

Article Multidisciplinary Sciences

Sparsely methylated mitochondrial cell free DNA released from cardiomyocytes contributes to systemic inflammatory response accompanied by atrial fibrillation

Masahiro Yamazoe et al.

Summary: Studies have shown that patients with atrial fibrillation (AF) have higher levels of cfDNA in their blood, especially mt-cfDNA. cfDNA and mt-cfDNA can promote the expression of IL-1 beta and IL-6 in macrophages through TLR9.

SCIENTIFIC REPORTS (2021)

Article Cell Biology

Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury

Qinjie Liu et al.

Summary: The STING pathway and its induction of autophagy play a crucial role in immune defense response against pathogenic DNA, but excessive activation of STING can exacerbate organ damage. Increased circulating mtDNA levels and STING activation in sALI patients contribute to lung injury by triggering an inflammatory response and disrupting autophagy. STING activation interferes with lysosomal acidification in an IFN-dependent manner, worsening sepsis.

CELL DEATH & DISEASE (2021)

Review Immunology

The cGAS-STING pathway as a therapeutic target in inflammatory diseases

Alexiane Decout et al.

Summary: The cGAS-STING signaling pathway plays a crucial role in inflammation in infection, cellular stress, and tissue damage settings. It has the ability to sense and regulate cellular responses to DNA and has the potential to be targeted in the treatment of various inflammatory diseases.

NATURE REVIEWS IMMUNOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Rapid Report Clinical Signi ficance of Circulating Cardiomyocyte-Speci fic Cell -Free DNA in Patients With Heart Failure: A Proof -of

Tetsuro Yokokawa et al.

CANADIAN JOURNAL OF CARDIOLOGY (2020)

Review Cardiac & Cardiovascular Systems

Reappraising the role of inflammation in heart failure

Luigi Adamo et al.

NATURE REVIEWS CARDIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Cytosolic DNA sensor cGAS plays an essential pathogenetic role in pressure overload-induced heart failure

Dan Hu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

Review Biochemistry & Molecular Biology

Mitochondrial DNA in inflammation and immunity

Joel S. Riley et al.

EMBO REPORTS (2020)

Article Cardiac & Cardiovascular Systems

Cardiac-specific methylation patterns of circulating DNA for identification of cardiomyocyte death

Qin Liu et al.

BMC CARDIOVASCULAR DISORDERS (2020)

Article Biochemistry & Molecular Biology

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

Jose A. Nicolas-Avila et al.

Review Biochemistry & Molecular Biology

Putative Origins of Cell-Free DNA in Humans: A Review of Active and Passive Nucleic Acid Release Mechanisms

Stefan Grabuschnig et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Immunology

Emerging roles of Toll-like receptor 9 in cardiometabolic disorders

Sachiko Nishimoto et al.

INFLAMMATION AND REGENERATION (2020)

Review Immunology

DAMP-sensing receptors in sterile inflammation and inflammatory diseases

Tao Gong et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Oncology

Life and death of circulating cell-free DNA

Anatoli Kustanovich et al.

CANCER BIOLOGY & THERAPY (2019)

Review Immunology

Pharmacological Inhibitors of the NLRP3 Inflammasome

Ayesha Zahid et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Cardiac & Cardiovascular Systems

Three in a Box: Understanding Cardiomyocyte, Fibroblast, and Innate Immune Cell Interactions to Orchestrate Cardiac Repair Processes

Stelios Psarras et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2019)

Review Biochemistry & Molecular Biology

Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases

Hiroyuki Nakayama et al.

BIOCHEMICAL JOURNAL (2018)

Article Biotechnology & Applied Microbiology

Polymer-Mediated Inhibition of Pro-invasive Nucleic Acid DAMPs and Microvesicles Limits Pancreatic Cancer Metastasis

Ibtehaj Naqvi et al.

MOLECULAR THERAPY (2018)

Review Immunology

ZBP1: Innate Sensor Regulating Cell Death and Inflammation

Teneema Kuriakose et al.

TRENDS IN IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

Non-invasive detection of human cardiomyocyte death using methylation patterns of circulating DNA

Hai Zemmour et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Targeting STING with covalent small-molecule inhibitors

Simone M. Haag et al.

NATURE (2018)

Article Multidisciplinary Sciences

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders

Liudmila Andreeva et al.

NATURE (2017)

Review Oncology

The role of reactive oxygen species in myocardial redox signaling and regulation

Demetrios Moris et al.

ANNALS OF TRANSLATIONAL MEDICINE (2017)

Article Cardiac & Cardiovascular Systems

Extracellular mtDNA activates NF-κB via toll-like receptor 9 and induces cell death in cardiomyocytes

Marte Bliksoen et al.

BASIC RESEARCH IN CARDIOLOGY (2016)

Review Oncology

Origins, structures, and functions of circulating DNA in oncology

A. R. Thierry et al.

CANCER AND METASTASIS REVIEWS (2016)

Editorial Material Cardiac & Cardiovascular Systems

Recounting Cardiac Cellular Composition

Pingzhu Zhou et al.

CIRCULATION RESEARCH (2016)

Article Cardiac & Cardiovascular Systems

Role of cell death in the progression of heart failure

Gordon W. Moe et al.

HEART FAILURE REVIEWS (2016)

Article Cardiac & Cardiovascular Systems

Inflammatory and fibrotic responses of cardiac fibroblasts to myocardial damage associated molecular patterns (DAMPs)

Neil A. Turner

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016)

Article Physiology

Pathophysiology of Heart Failure

Edit Tanai et al.

COMPREHENSIVE PHYSIOLOGY (2016)

Review Immunology

Discriminating self from non-self in nucleic acid sensing

Martin Schlee et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Review Biochemistry & Molecular Biology

Pathologic function and therapeutic potential of exosomes in cardiovascular disease

Shaina Ailawadi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2015)

Article Cardiac & Cardiovascular Systems

Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats

Cameron G. McCarthy et al.

CARDIOVASCULAR RESEARCH (2015)

Review Cardiac & Cardiovascular Systems

Innate Immunity and the Failing Heart The Cytokine Hypothesis Revisited

Douglas L. Mann

CIRCULATION RESEARCH (2015)

Editorial Material Cardiac & Cardiovascular Systems

Plasma nuclear and mitochondrial DNA levels in acute myocardial infarction patients

Jon D. Simmons et al.

CORONARY ARTERY DISEASE (2015)

Review Immunology

Role of innate and adaptive immune mechanisms in cardiac injury and repair

Slava Epelman et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Review Medicine, Research & Experimental

Innate immunity and cardiomyocytes in ischemic heart disease

Li Lin et al.

LIFE SCIENCES (2014)

Review Cardiac & Cardiovascular Systems

The inflammatory response in myocardial injury, repair, and remodelling

Nikolaos G. Frangogiannis

NATURE REVIEWS CARDIOLOGY (2014)

Article Multidisciplinary Sciences

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart

Kory J. Lavine et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemical Research Methods

Structural mechanism of DNA recognition by the p202 HINa domain: insights into the inhibition of Aim2-mediated inflammatory signalling

He Li et al.

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2014)

Review Cardiac & Cardiovascular Systems

Contributions of cardiomyocyte-cardiac fibroblast-immune cell interactions in heart failure development

Katsuhito Fujiu et al.

BASIC RESEARCH IN CARDIOLOGY (2013)

Review Cell Biology

Extracellular vesicles: Exosomes, microvesicles, and friends

Graca Raposo et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Immunology

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA

Cherilyn M. Sirois et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

Review Cell Biology

Danger Signals in the Initiation of the Inflammatory Response after Myocardial Infarction

J. J. de Haan et al.

MEDIATORS OF INFLAMMATION (2013)

Review Cell Biology

Oxidized Extracellular DNA as a Stress Signal in Human Cells

Aleksei V. Ermakov et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)

Article Multidisciplinary Sciences

TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons

Yasunori Shintani et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Immunology

Nucleic acids and endosomal pattern recognition: how to tell friend from foe?

Eva Brencicova et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2013)

Review Cardiac & Cardiovascular Systems

Cross talk between cardiac myocytes and fibroblasts: from multiscale investigative approaches to mechanisms and functional consequences

P. Zhang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2012)

Article Cardiac & Cardiovascular Systems

S100A8/A9 aggravates post-ischemic heart failure through activation of RAGE-dependent NF-κB signaling

H. Christian Volz et al.

BASIC RESEARCH IN CARDIOLOGY (2012)

Article Multidisciplinary Sciences

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

Takafumi Oka et al.

NATURE (2012)

Article Multidisciplinary Sciences

Cardiomyocyte Microvesicles Contain DNA/RNA and Convey Biological Messages to Target Cells

Anders Waldenstrom et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Nucleic acid scavengers inhibit thrombosis without increasing bleeding

Shashank Jain et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Cardiac & Cardiovascular Systems

Oxidative stress and heart failure

Hiroyuki Tsutsui et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2011)

Review Immunology

The PYHIN protein family as mediators of host defenses

Stefan A. Schattgen et al.

IMMUNOLOGICAL REVIEWS (2011)

Article Multidisciplinary Sciences

Nucleic acid-binding polymers as anti-inflammatory agents

Jaewoo Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Biochemistry & Molecular Biology

Pattern Recognition Receptors and Inflammation

Osamu Takeuchi et al.

Review Biochemistry & Molecular Biology

The virtosome-a novel cytosolic informative entity and intercellular messenger

Peter B. Gahan et al.

CELL BIOCHEMISTRY AND FUNCTION (2010)

Review Biochemistry & Molecular Biology

Secondary necrosis: The natural outcome of the complete apoptotic program

Manuel T. Silva

FEBS LETTERS (2010)

Article Cardiac & Cardiovascular Systems

Cell-free DNA levels in acute myocardial infarction patients during hospitalization

Aspasia Destouni et al.

ACTA CARDIOLOGICA (2009)

Article Cardiac & Cardiovascular Systems

High-mobility group box-1 in ischemia-reperfusion injury of the heart

Martin Andrassy et al.

CIRCULATION (2008)

Article Cardiac & Cardiovascular Systems

Cell Death in Heart Failure

Kazuhiko Nishida et al.

CIRCULATION JOURNAL (2008)

Article Biochemistry & Molecular Biology

Extracellular circulating nucleic acids in human plasma in health and disease

PP Laktionov et al.

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2004)

Article Medical Laboratory Technology

Elevated cell-free serum DNA detected in patients with myocardial infarction

CPY Chang et al.

CLINICA CHIMICA ACTA (2003)

Article Cell Biology

Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts

DA Siwik et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2001)