期刊
CHEMICAL COMMUNICATIONS
卷 51, 期 50, 页码 10214-10217出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc02199e
关键词
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资金
- National Cancer Institute of the US National Institutes of Health [R01CA88986]
- Mayo Breast Specialized Programs of Research Excellence (SPORE) [P50CA116201]
- Mayo Pancreas SPORE [P50CA102701]
- NATIONAL CANCER INSTITUTE [P50CA102701, R01CA088986, P50CA116201] Funding Source: NIH RePORTER
A strategy for the linear synthesis of a sialylated glycolipopeptide cancer vaccine candidate has been developed using a strategically designed sialyl-Tn building block and microwave-assisted solid-phase peptide synthesis. The glycolipopeptide elicited potent humoral and cellular immune responses. T-cells primed by such a vaccine candidate could be restimulated by tumor-associated MUC1.
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