期刊
ADVANCES IN NATURAL SCIENCES-NANOSCIENCE AND NANOTECHNOLOGY
卷 14, 期 2, 页码 -出版社
IOP Publishing Ltd
DOI: 10.1088/2043-6262/acd0aa
关键词
prostate cancer; green gold nanoparticles; bioactive molecules; D2B; scFvD2B
Green nanotechnology produces biocompatible gold nanoparticles (AuNPs) with inherent anti-microbial, anti-viral, and anti-tumour properties, which are gaining popularity in prostate cancer (PC) nanotherapy. This review compares and summarizes data from studies published between 2015 and 2022, highlighting the major biological compounds and outcomes of in vitro and in vivo applications of green or biosynthesized AuNPs in PC theranostics. The use of green AuNPs shows promising antiproliferative characteristics in PC, with various apoptosis-related mechanisms and successful delivery of biological compounds. Furthermore, green AuNPs offer a potential modality for targeted cancer therapy and address ethical concerns and toxicity risks in clinical trials.
Green nanotechnology produces biocompatible gold nanoparticles (AuNPs) with intrinsic anti-microbial, anti-viral, and anti-tumour properties. Green AuNPs (g-AuNPs) are gaining a solid ground in prostate cancer (PC) nanotherapy. Hence, in this review, we summarise and compare data from studies published between 2015 and 2022 to highlight major biological compounds and outputs from in vitro and in vivo applications of green or biosynthesised AuNPs in PC theranostics. In fact, g-AuNPs can be easily generated with effective antiproliferative PC characteristics. Taken together, g-AuNPs exert various apoptosis-related mechanisms, such as reactive oxygen species (ROS) generation, cell cycle arrest, cytotoxicity, mitochondrial disruption, and anti-tumour immune cell activation, with additional successful delivery of the biological compounds in green materials. g-AuNPs could offer another modality for targeted cancer therapy using antibodies and targeting ligands to specifically recognise and destroy PC tumours. In conclusion, g-AuNPs applications drive forth sustainable nanotechnology while minimising ethical concerns and toxicity risks in clinical trials.
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