期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 67, 期 -, 页码 395-408出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2016.04.106
关键词
Hydroxyapatite coatings; Nanoplate arrays; Nanorod arrays; Cytocompatibility; Osteogenic differentiation
资金
- Natural Science Foundation of China [51372152]
- Key Disciplines of Shanghai Municipal Education Commission [J50206]
- Science and Technology Commission of Shanghai Municipality [12JC1405600]
- Program of Shanghai Normal University [DZL124, DCL201303]
- Innovation Foundation of Shanghai Education Committee [14ZZ-124]
Hydroxyapatite (HA) crystals exhibit rod-like shape with c-axis orientation and plate-like shape with a(b)-axis orientation in vertebrate bones and tooth enamel surfaces, respectively. Herein, we report the synthesis of HA coatings with the oriented nanorod arrays (RHACs) and HA coatings with oriented nanoplate arrays (PHACs) by using bioglass coatings as sacrificial templates. After soaking in simulated body fluid (SBF) at 120 degrees C, the bioglass coatings are hydrothermally converted into the HA coatings via a dissolution-precipitation reaction. If the Ca/P ratios in SBF are 2.50 and 1.25, the HA crystals on the coatings are oriented nanorod arrays and oriented nanoplate arrays, respectively. Moreover, the bioglass coatings are treated with SBF at 37 degrees C, plate-like HA coatings with a low crystallinity (SHACs) are prepared. As compared with the Ti6Al4V and SHACs, the human bone marrow stromal cells (hBMSCs) on the RHACs and PHACs have better cell adhesion, spreading, proliferation and osteogenic differentiation because of their moderately hydrophilic surfaces and similar chemical composition, morphology and crystal orientation to human hard tissues. Notably, the morphologies of HA crystals have no obvious effects on cytocompatibility and osteogenic differentiation. Hence, the HA coatings with oriented nanoplate arrays or oriented nanorod arrays have a great potential for orthopedic applications. (C) 2016 Elsevier B.V. All rights reserved.
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