期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 69, 期 -, 页码 407-413出版社
ELSEVIER
DOI: 10.1016/j.msec.2016.06.082
关键词
Biodegradable Zn-based alloy; Mechanical properties; Biodegradation behavior; Cytotmdcity; Antibacterial effect
资金
- National Natural Science Foundation of China [51501115]
- Science and Technology Commission of Shanghai [14DZ1940800, 15ZR1422600]
- Medical-Engineering Cross Fund of Shanghai Jiao Tong University [YG2015MS66, YG2014MS62]
- Science and Technology Commission of Minhang District Shanghai [2014MH124]
Zn-based alloys have been viewed as new potential materials for biodegradable implants, such as cardiovascular stents, mainly in consideration of their lower corrosion rate when compared with that of Mg alloys. In this study we developed a new Zinc-4 wt%Copper (Zn-4Cu) alloy as a biodegradable material. Hot extrusion was applied to Zn-4Cu to refine the microstructure and consequently improve its mechanical properties and corrosion resistance. After extrusion, dendritic CuZns phases were broken and distributed along the extrusion direction. The grains were refined obviously due to dynamical recrystallization. The yield strength (YS), ultimate tensile strength (UTS) and elongation of the as-extruded alloy are 250 +/- 10 MPa, 270 +/- 10 MPa and 51 +/- 2%, respectively. The corrosion rate of the as-extruded alloy in Hank's solution is about 9.41(+/- 134) pm year In vitro evaluation shows that Zn-4Cu presents acceptable toxicity to human endothelial cells, and could effectively inhibit bacteria adhesion and biofilm formation. The present study indicates that the as-extruded Zn-4Cu alloy exhibits excellent strength and ductility, uniform and slow degradation, good biocompatibility and significant antibacterial effect, which make it an excellent candidate material for biodegradable implants, especially for cardiovascular stents application. (C) 2016 Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据