期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 59, 期 -, 页码 509-513出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2015.10.043
关键词
Poly (N-isopropylacrylamide); Polymer molecular weight; Cytotoxicity; Thermosensitive hydrogel; Tissue engineering; Drug delivery
资金
- 111 Project [B12034]
Poly (N-isopropylacrylamide) (PNIPAAm) is a thermosensitive polymer with various biomedical applications. We examined molecular weight (MW)-dependent cytotoxicity of PNIPAAm. Our results indicated that low-MW PNIPAAm (degree of polymerization (DP) = 35) is inherently toxic to cells. Moderate-MW PNIPAAms with their DP between 100 and 200 are non-cytotoxic. When cells are seeded on top of a polymer-coated surface, PNIPAAm with a higher MW (DP = 400) shows non/low cytotoxicity, while when monolayer cells are exposed to the polymer solution, cell viability drops drastically. This may be due to lack of nutrient and oxygen rather than intrinsic toxicity of the polymer. (C) 2015 Elsevier B.V. All rights reserved.
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