期刊
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 61, 期 -, 页码 665-673出版社
ELSEVIER
DOI: 10.1016/j.msec.2015.12.067
关键词
Naproxen; Conjugation; Methoxy poly(ethylene glycol)-poly(epsilon-caprolactone) copolymers; Micelle; Triggered drug delivery
资金
- Zanjan University of Medical Sciences [A-12-233-10]
A conjugate of the NSAIDs drug, naproxen, with diblock methoxy poly(ethylene glycol)-poly(epsilon-caprolactone) (mPEG-PCL) copolymer was synthesized by the reaction of copolymer with naproxen in the presence of dicyclohexylcarbodiimide and dimethylaminopyridine. The naproxen conjugated copolymers were characterized with different techniques including (HNMR)-H-1, FTIR, and DSC The naproxen conjugated mPEG-PCL copolymers were self-assembled into micelles in aqueous solution. The TEM analysis revealed that the micelles had the average size of about 80 nm. The release behavior of conjugated copolymer was investigated in two different media with the pH values of 7.4 and 5.2. In vitro release study showed that the drug release rate was dependant on pH as it was higher at lower pH compared to neutral pH. Another feature of the conjugated micelles was a more sustained release profile compared to the conjugated copolymer. The kinetic of the drug release from naproxen conjugated micelles under different values of pH was also investigated by different kinetic models such as first order, Makoid-Banakar, Weibull, Logistic, and Gompertz. (C) 2015 Elsevier B.V. All rights reserved.
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