期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 58, 期 -, 页码 194-203出版社
ELSEVIER
DOI: 10.1016/j.msec.2015.08.027
关键词
Borosilicate glass; Copper doping; Glass network; Glass scaffolds; Biodegradation
资金
- Shanghai Committee of Science and Technology, China [12JC1408500]
- National Natural Science Foundation, China [51072133, 51272274, 51372170]
Copper doped borosilicate glasses (BG-Cu) were studied by means of FT-IR, Raman, UV-vis and NMR spectroscopies to investigate the changes that appeared in the structure of borosilicate glass matrix by doping copper ions. Micro-fil and imMunohistochemistry analysis were applied to study the angiogenesis of its derived scaffolds in vivo. Results indicated that the Cu ions significantly increased the B-O bond of BO4 groups at 980 cm(-1), while they decrease that of BO2O- groups at 1440-1470 cm(-1) as shown by Raman spectra. A negative shift was observed from B-11 and Si-29 NMR spectra. The B-11 NMR spectra exhibited a clear transformation from BO3 into BO4 groups, caused by the agglutination effect of the Cu ions and the charge balance of the agglomerate in the glass network, leading to a more stable glass network and lower ions release rate in the degradation process. Furthermore, the BG-Cu scaffolds significantly enhanced blood vessel formation in rat calvarial defects at 8 weeks post-implantation. Generally, it suggested that the introduction of Cu into borosilicate glass endowed glass and its derived scaffolds with good properties, and the cooperation of Cu with bioactive glass may pave a new way for tissue engineering. (C) 2015 Elsevier B.V. All rights reserved.
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