期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 62, 期 -, 页码 692-701出版社
ELSEVIER
DOI: 10.1016/j.msec.2016.02.013
关键词
Silver; beta-Ca-3(PO4)(2); Chitosan; Composite; Ti metal
资金
- Department of Science and Technology, DST, India [SB/FT/CS-101/2012(SR)]
- European Regional Development Fund (FEDER) through COMPETE
- Portuguese Government through Portuguese Foundation for Science and Technology (FCT) [UID/CTM/50011/2013]
- [PTDC/CTM/99489/2008]
- Fundação para a Ciência e a Tecnologia [PTDC/CTM/099489/2008] Funding Source: FCT
Pure and five silver-doped (0-5Ag) beta-tricalcium phosphate [beta-TCP, beta-Ca-3(PO4)(2)]/chitosan composite coatings were deposited on Titanium (Ti) substrates and their properties that are relevant for applications in hard tissue replacements were assessed. Silver, beta-TCP and chitosan were combined to profit from their salient and complementary antibacterial and biocompatible features. The beta-Ca-3(PO4)(2) powders were synthesized by co-precipitation. The characterization results confirmed the Ag+ occupancy at the crystal lattice of beta-Ca-3(PO4)(2). The Ag-doped beta-Ca-3(PO4)(2)/chitosan composite coatings deposited by electrophoresis showed good antibacterial activity and exhibited negative cytotoxic effects towards the human osteosarcoma cell line MG-63. The morphology of the coatings was observed by SEM and their efficiency against corrosion of metallic substrates was determined through potentiodynamic polarization tests. (C) 2016 Elsevier B.V. All rights reserved.
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