期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 66, 期 -, 页码 147-155出版社
ELSEVIER
DOI: 10.1016/j.msec.2016.03.102
关键词
Electrospinning; Benign solvent; P(3HB-co-4HB); Collagen peptides; Wound dressing
资金
- Ministry of Science, Technology and Innovation (MOSTI), e-Science Fund [02-05-23-SF0003]
The main focus of this study is the incorporation of collagen peptides to fabricate P(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] nano-fiber construct to further enhance surface wettability and support cell growth while harbouring desired properties for biodegradable wound dressing. Simultaneous electrospinning of nanofiber P(3HB-co-4HB)/collagen peptides construct was carried out using dual syringe system. The wettability of the constructs increased with the increase in 4HB molar fraction from 20 mol% 4HB [53.2 degrees], P(3HB-co-35 mol%4HB)[48.9 degrees], P(3HB-co-50 mol%4HB)[44.5 degrees] and P(3HB-co-82 mol%4HB) [37.7 degrees]. In vitro study carried out using mouse fibroblast cells (L929) grown on nanofiber P(3HB-co-4HB)/collagen peptides construct showed an increase in cell proliferation. In vivo study using animal model (Sprague Dawley rats) showed that nanofibrous P(3HB-co-4HB)/collagen peptides construct had a significant effect on wound contractions with the highest percentage of wound closure of 79%. Hence, P(3HB-co-4HB)/collagen peptides construct suitable for wound dressing have been developed using nano-fabrication technique. (C) 2016 Elsevier B.V. All rights reserved.
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