Loading of atorvastatin and linezolid in β-cyclodextrin-conjugated cadmium selenide/silica nanoparticles: A spectroscopic study

The preparation of beta-cyclodextrin-conjugated cadmium selenide-silica nanoparticles, the loading of two drugs viz., Atorvastatin and linezolid in the cyclodextrin cavity, and the fluorescence energy transfer between CdSe/SiO2 nanoparticles and the drugs encapsulated in the cyclodextrin cavity are reported in this paper. IR spectroscopy, X-ray diffractometry, transmission electron microscopy, and particle size analysis by light-scattering experiment were used as the tools of characterizing the size and the crystal system of the nanoparticles. The nanoparticles fall under hexagonal system. The silica-shell containing CdSe nanoparticles were functionalized by reaction with aminoethylamino-beta-cyclodextrin. Fluorescence spectra of the nanopartides in their free and drug-encapsulated forms were studied. The FOrster distances between the encapsulated drugs and the CdSe nanoparticles are below 3 nm. The change in the FOrster resonance energy parameters under physiological conditions may aid in tracking the release of drugs from the cavity of the cyclodextrin. (C) 2016 Elsevier B.V. All rights reserved.