Simultaneous determination of ascorbic acid, acetaminophen and codeine based on multi-walled carbon nanotubes modified with magnetic nanoparticles paste electrode

Based on incorporating ZnCrFeO4 into multi-walled carbon nanotubes paste matrix (MWCNTs/ZnCrFeO4/CPE), a chemically modified electrode was prepared for the simultaneous determination of ascorbic add (AA), acetaminophen (AC) and codeine (CO). The prepared electrode, MWCNTs/ZnCrFeO4/CPE, was characterized by scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). The MWCNTs/ZnCrFeO4/CPE showed an efficient electrocatalytic activity for the oxidation of AA, AC, and CO. The separations of the oxidation peak potentials for AA-AC and AC-CO were about 250 mV and 630 mV, respectively. The calibration curves obtained for AA, AC, and CO were in the ranges of 0.4-730.0 mu mol L-1,0.1-368.0 mu mol L-1, and 03-250.0 mu mol L-1, respectively. The detection limits (S/N = 3) were 0.03 mu mol L-1,0.009 mu mol L-1, and 0.01 mu mol L-1 for AA, AC, and CO, respectively. The method was also successfully employed as a selective, simple, and precise method to determinate AA, AC, and CO in pharmaceutical and biological samples. (C) 2016 Elsevier B.V. All rights reserved.