期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 67, 期 -, 页码 599-610出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2016.05.081
关键词
Tussah silk fibroin; Electrospinning; Nanofiber fabric; Bone formation; Bone tissue engineering
资金
- National Natural Science Foundation of China [51203196, U1204510]
- Program for Science & Technology Innovation Talents in Universities of Henan Province of China [15HASTIT024]
- Program for Science & Technology Innovation Teams in Universities of Henan Province of China [16IRTSTHN006]
To engineer bone tissue, a scaffold with good biological properties should be provided to approximate the hierarchical structure of collagen fibrils in natural bone. In this study, we fabricated a novel scaffold consisting of multilayer nanofiber fabrics (MLNFFs) by weaving nanofiber yarns of polylactic acid (PLA) and Tussah silk fibroin (TSF). The yarns were fabricated by electrospinning, and we found that spinnability, as well as the mechanical properties of the resulting scaffold, was determined by,the ratio between polylactic acid and Tussah silk fibroin. In, particular, a 9:1 mixture can be spun continuously into nanofiber yarns with narrow diameter distribution and good mechanical properties. Accordingly, woven scaffolds based on this mixture had excellent mechanical properties, with Young's modulus 417.65 MPa and tensile strength 180.36 MPa. For nonwoven scaffolds fabricated from the same materials, the Young's modulus and tensile strength were 2- and 4-fold lower, respectively. Woven scaffolds also supported adhesion and proliferation of mouse mesenchymal stem cells, and promoted bio-mineralization via alkaline phosphatase and mineral deposition. Finally, the scaffolds significantly enhanced the formation of new bone in damaged femoral condyle in rabbits. Thus, the scaffolds are potentially suitable for bone tissue engineering because of biomimetic architecture, excellent mechanical properties, and good biocompatibility. (C) 2016 Elsevier B.V. All rights reserved.
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