期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 62, 期 -, 页码 444-449出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2016.01.071
关键词
Magnetic biomaterials; Scanning probes; Nanomedicine; Tissue engineering; Percolation; Escherichia coli adhesion
资金
- Dresden High Magnetic Field Laboratory (HLD), an Institute of the Helmholtz-Zentrum Dresden-Rossendorf (HZRD, Science center of the Helmholtz association), member of the European Magnetic Field Laboratory (EMFL)
Hydroxyapatite films enriched with magnetite have been fabricated via a Pulsed Plasma Deposition (PPD) system with the final aim of representing a new platform able to disincentivate bacterial adhesion and biofilm formation. The chemical composition and magnetic properties of films were respectively examined by X-ray photoelectron spectroscopy (XPS) and Superconducting Quantum Interference Device (SQUID) measurements. The morphology and conductive properties of the magnetic films were investigated via a combination of scanning probe technologies including atomic force microscopy (AFM), electrostatic force microscopy (EFM), and scanning tunneling microscopy (STM). Interestingly, the range of adopted techniques allowed determining the preservation of the chemical composition and magnetic properties of the deposition target material while STM analysis provided new insights on the presence of surface inhomogeneities, revealing the presence of magnetite-rich islands over length scales compatible with the applications. Finally, preliminary results of bacterial adhesion tests, indicated a higher ability of magnetic hydroxyapatite films to reduce Escherichia coli adhesion at 4 h from seeding compared to control hydroxyapatite films. (C) 2016 Elsevier B.V. All rights reserved.
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