期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 59, 期 -, 页码 847-854出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2015.10.088
关键词
Chemically modified electrode; Citalopram determination; Electrochemical sensor; Square wave voltammetry; Human serum; Pharmaceutical preparations
资金
- Bu-Ali Sina University Research Council
- Center of Excellence in Development of Environmentally Friendly Methods for Chemical Synthesis (CEDEFMCS)
A new chemically modified carbon paste electrode (CMCPE) was applied to the simple, rapid, highly selective and sensitive determination of citalopram in human serum and pharmaceutical preparations using adsorptive square wave voltammetry (ASWV). The ZnO nanoparticles and multi-walled carbon nanotubes modified CPE (ZnO-MWCNT/CPE) electrode was prepared by incorporation of the ZnO nanopartides and multi-walled carbon nanotubes (MWCNT) in carbon paste electrode. The limit of detection and the linear range were found to be 0.005 and 0.012 to 1.54 mu mol L-1 of citalopram, respectively. The effects of potentially interfering substances on the determination of this compound were investigated and found that the electrode is highly selective. The proposed CMCPE was used to the determination of citalopram in human serum, urine and pharmaceutical samples. This reveals that ZnO-MWCNT/CPE shows excellent analytical performance for the determination of citalopram in. terms of very low detection limit, high sensitivity, very good repeatability and reproducibility over other methods reported in the literature. (C) 2016 Elsevier B.V. All rights reserved.
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