期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 65, 期 -, 页码 345-353出版社
ELSEVIER
DOI: 10.1016/j.msec.2016.04.050
关键词
Reduced graphene oxide; Grape seed extract; Reduction; Anti-proliferative activity
资金
- University Grants Commission (UGC), New Delhi [2061010223]
- Department of Science and Technology (DST-Inspire fellowship)
- DST Nano Mission, New Delhi [SR/NM/NS-54/2009]
- Centre for Advanced Materials (CAM), Qatar University
The development of functionalized graphene materials concerning health and environmental aspects via green approaches is currently the most recent topic in the field of nanoscience and nanotechnology. Herein, we report the green reduction of graphene oxide (GO) to reduced graphene oxide (RGO) using grape seed extract (GSE). Structural properties of the prepared RGO were investigated using Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, thermogravimetric analysis (TGA), UV Visible spectroscopy and X-ray diffraction analysis. These all characterization techniques clearly revealed that the RGO has been successfully prepared. Moreover, the average thickness (4.2 nm) of RGO layers was also confirmed by transmission electron microscopy (TEM). Optical properties such as band gap and photoluminescence of the synthesized RGO were evaluated. The band gap of RGO was found to be 3.84 eV and it showed emission in the visible region. Efficient antimicrobial activity against Escherichia coli and Staphylococcus aureus was observed with 4 mu g ml(-1) & 5 mu g ml(-1) of RGO and also the cell wall damage of these strains has been proved by atomic force microscopy (AFM). The in vitro study of RGO (500 mu g) disclosed the effective anti-proliferative activity (88%) against HCT-116 cell lines. (C) 2016 Elsevier B.V. All rights reserved.
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