Square wave voltammetric determination of paracetamol at chitosan modified carbon paste electrode: Application in natural water samples, commercial tablets and human urines

A novel analytical approach has been developed and evaluated for the quantitative analysis of paracetamol (PCT). The anodic peak currents of paracetamol on the CS-CPE were about 200 fold higher than that of the unmodified electrodes. The influence of various parameters on the CS-CPE was investigated. Under the optimized working conditions, the oxidation peak current is linear to the paracetamol concentration in the ranges of 1.0 x 4.0 x 10(-4) mol L-1 and 2.0 x 10(-4)-8.0 x 10(-7) mol L-1 with a detection limit of 5.08 x 10(-7) mol L. The repeatability of the method expressed as relative standard deviation (RSD) is 1.73% (n = 8). Possible interferences were tested and evaluated in 1.0 x 10(-4) mol L-7 paracetamol in the presence of inorganic ions, dopamine, ibuprofen, ascorbic acid and uric acid. The proposed method was successfully applied to PCT determination in natural waters, tablets and urine samples. (C) 2015 Elsevier B.V. All rights reserved.