期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 58, 期 -, 页码 1090-1097出版社
ELSEVIER
DOI: 10.1016/j.msec.2015.09.080
关键词
Gold nanorods; Nanofibers; Polyvinyl alcohol; Chitosan; Electrospinning
资金
- NSFC [51273056, 51272110, 21202091, 21372067, 51303045, 51473046]
- Program for New Century Excellent Talent of Ordinary College in Heilongjiang Province [1254-NCET-024]
- Natural Science Foundation of Heilongjiang Province [C201225, C2015049]
- Project of Qiqihar University Graduate Innovation Science [20150911]
Gold nanorods (AuNRs) that contained polyvinyl alcohol/chitosan (PVA/CS) hybrid nanofibers with dual functions are successfully fabricated by a simple electrospinning method. The results of transmission electron microscopy (TEM), X-ray diffraction (XRD) and energy dispersive X-ray (EDX) spectroscopy indicate that AuNRs are indeed encapsulated into the PVA/CS hybrid nanofibers. FOR spectra results demonstrate that the chemical structures of PVA and CS are not affected when the AuNRs are introduced into the fibers. In vitro cytotoxicity test reveals that the hybrid fibers involving AuNRs are completely biocompatible. The as-prepared fibers can be used as a carrier for anticancer agent doxorubicin (DOX), and the drug is delivered into the cell nucleus. The AuNRs and DOX incorporated fibers are effective for inhibiting the growth and proliferation of ovary cancer cells and they can also be used as the cell imaging agent due to the unique optical properties of AuNRs. The nanofiber matrix combining two functions of cell imaging and drug delivery may be of great application potential in biomedical-related areas. (c) 2015 Elsevier B.V. All rights reserved.
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