期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 66, 期 -, 页码 178-184出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2016.04.067
关键词
Hydrogel; Textural analysis; Biocompatibility; Biomaterial; Biomedical application; Sol-gel
资金
- Council of Scientific and Industrial Research (CSIR)
- CSIR, India [CSC 0134]
In the recent past, keratin has been fabricated into different forms of biomaterials like scaffold, gel, sponge, film etc. In lieu of the myriad advantages of the hydrogels for biomedical applications, a keratin-silica hydrogel was fabricated using tetraethyl orthosilicate (TEOS). Textural analysis shed light on the physical properties of the fabricated hydrogel, inturn enabling the optimization of the hydrogel. The optimized keratin-silica hydrogel was found to exhibit instant springiness, optimum hardness, with ease of spreadability. Moreover, the hydrogel showed excellent swelling with highly porous microarchitecture. MIT assay and DAPI staining revealed that keratin-silica hydrogel was biocompatible with fibroblast cells. Collectively, these properties make the fabricated keratin-silica hydrogel, a suitable dressing material for biomedical applications. (C) 2016 Elsevier B.V. All rights reserved.
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