期刊
JOURNAL OF DIETARY SUPPLEMENTS
卷 -, 期 -, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/19390211.2023.2179154
关键词
Autism spectrum disorder (ASD); dysbiosis and gut microbiota-brain axis; gut microbiota; vitamin A deficiency (VAD)
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by a lack of social behaviors, repetitive behaviors and nonverbal interactions. Studies have shown that the gut microbiota may play a role in the pathophysiology of ASD. However, the relationship between the gut microbiota and ASD is still not fully understood.
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders defined by a lack of social behaviors, repetitive behaviors and nonverbal interactions, such as limited eye contact, facial expression, and body gesturing. It is not a single condition, but rather a multi-factorial disorder caused by hereditary and non-genetic risk factors, as well as their interaction. According to several studies, the gut microbiota may have a role in the pathophysiology of autism spectrum disorder. Various studies have found differences in the composition of the gastrointestinal (GI) microbiota in children with ASD compared to unaffected siblings and/or healthy unrelated controls. The processes that relate the gut microbiota to brain dysfunctions (the gut-brain axis) in ASD are yet to be fully understood. However, the differences in the gastrointestinal composition might be due to vitamin A deficiency because vitamin A (VA) plays a role in the regulation of the intestinal microbiota. This narrative review discusses the impact of vitamin A deficiency on the gut microbiota composition and tries to understand how this may contribute for the development and severity of ASD.
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