Development of an Electrochemical Sensor Modified with Dealuminated Zeolite with Citric Acid for Hydroxyzine Determination by BIA-Amperometry

An electrochemical sensor modified with zeolite dealuminated with citric acid was developed for the determination of hydroxyzine in pharmaceutical products during BIA-amperometry experiments. The modified electrochemical sensor was prepared by mixing powdered graphite with zeolite treated with citric acid homogenized with hexane and mineral oil (60:20:20% w/w/w respectively). The developed sensor showed reproducible amperometric responses in a linear range of 1.0x10(-6) - 2.0x10(-5) mol L-1 in +1,28 V (vs. Ag/AgCl). The detection limit and detection limit found were 3.10x10(-7) mol L-1 e 1.04x10(-6) mol L-1, respectively. The method developed by BIA-amperometry was applied for the determination of the analyte in tablets and commercial syrups and the results found agreement with the nominal values of the commercial samples.

Automated summary

An electrochemical sensor modified with zeolite dealuminated with citric acid was developed for the determination of hydroxyzine in pharmaceutical products. The modified sensor showed reproducible amperometric responses in a linear range of 1.0x10(-6) - 2.0x10(-5) mol L-1. The method developed by BIA-amperometry was applied for the determination of the analyte in tablets and commercial syrups and the results found agreement with the nominal values of the commercial samples.