期刊
MATERIALS LETTERS
卷 184, 期 -, 页码 211-215出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2016.08.077
关键词
Nanopetal; Fibroblast; Epithelial Cells; Adhesion; Migration; Carbon-based Materials
资金
- U.S. AFRL, AFOSR under MURI Program [FA9550-12-1-0037]
- U.S. National Science Foundation [1344654]
- Purdue University
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1344654] Funding Source: National Science Foundation
Carbon-based nanomaterials have emerged in a wide variety of applications because of their tunable mechanical, electrical, chemical and optical properties. However, poor cellular adhesion makes their use significantly limited in tissue engineering and regenerative medicines. In order to address this challenge, we studied interactions of fibroblast and epithelial cells with graphitic nanopetal structures grown on carbon fibers. We found that all the cell types studied attached to and migrated along the nanopetal coated carbon fibers, but not to the non-coated fibers. The petals' nanoscale irregular geometry is thought to enhance cellular adhesion and migration. Further understanding of the mechanisms of this interaction and improvising this method may be useful to design novel tissue engineering strategies using carbon-based nanomaterials. (C) 2016 Elsevier B.V. All rights reserved.
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