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Article Chemistry, Organic

C-H Bond Functionalization of Amines: A Graphical Overview of Diverse Methods

Subhradeep Dutta et al.

Summary: This review provides a concise overview of the methods that enable the functionalization of sp(3) C-H bonds in amines and their derivatives.

SYNOPEN (2021)

Article Chemistry, Organic

Simple and Efficient Synthesis of Allyl Sulfones through Cs2CO3- Mediated Radical Sulfonylation of Morita-Baylis-Hillman Adducts with Thiosulfonates

Angothu Shankar et al.

Summary: A highly efficient and eco-friendly method has been developed for the synthesis of allyl sulfones using Morita-Baylis-Hillman (MBH) adducts and thiosulfonates under mild conditions. The Cs2CO3-promoted radical sulfonylation provided a series of ally! sulfones in good to high yields with high stereoselectivities. A wide variety of MBH bromides/acetates as well as thiosulfonates were tolerated and reliable in scaled-up synthesis.

SYNOPEN (2021)

Article Chemistry, Organic

A Catalytic, Oxidative Synthesis of Olivetol, Methyl Olivetolate and Orthogonally Protected Methyl Ether Derivatives

David Hurem et al.

Summary: Using an atom-economical, catalytic oxidative aromatization process, olivetol, methyl olivetolate and a series of orthogonally protected methyl ether derivatives were synthesized from commonly available precursors.

SYNOPEN (2021)

Article Chemistry, Organic

Development of a Continuous Photochemical Benzyne-Forming Process

Cormac Bracken et al.

Summary: A new methodology utilizing a high-power LED lamp for the safe generation and derivatization of benzyne under photochemical conditions is presented. The continuous-flow process effectively controls the release of gaseous by-products and delivers a series of heterocyclic products in a short residence time. This robust methodology enables the rapid generation of important heterocyclic scaffolds through a simple and scalable flow protocol.

SYNOPEN (2021)