期刊
MATERIALS LETTERS
卷 167, 期 -, 页码 175-178出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2015.12.151
关键词
Supercritical CO2; Silk fibroin; Drug delivery system; Curcumin
资金
- Hong Kong Polytechnic University [PolyU5242/09E, G-YM63]
- Guangdong Provincial Department of Science and Technology [2012B050800002, 2012B091000143]
A silk fibroin (SF)-derived nanofibrous drug delivery system was fabricated by solution-enhanced dispersion via supercritical CO2 (SEDS) (20 MPa pressure, 8 mL/min flow rate, 35 degrees C temperature) in this study. Curcumin (CM) was used as a water-insoluble drug model. Nanofibrous structure with controllable fiber diameter (< 100 nm) was obtained, and inter-molecular hydrogen bonds were formed between CM and SF; the crystallinity of the incorporated CM was remarkably decreased, which led to a significant enhancement in solubility of incorporated CM. In conclusion, SEDS could be developed to fabricate polymeric nanofibrous drug delivery system. (C) 2016 Published by Elsevier B.V.
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