期刊
MATERIALS LETTERS
卷 178, 期 -, 页码 31-34出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2016.04.177
关键词
Polymeric composites; Proteins; Electrospinning; Fiber technology; Drug-loading; Controlled release
资金
- National Natural Science Foundation of China [21274028]
In this article, the regenerated silk fibroin/2-hydroxypropyl-beta-cyclodextrin/tamoxifen (RSF/2-HP-beta-CD/TAM) composite fibers are successfully prepared via an electrospinning technique. 2-HP-beta-CD/TAM inclusion complex is firstly formed to increase the TAM solubility in the spinning dope. The morphology of the electrospun fibers is investigated, which shows the addition of 2-HP-beta-CD/TAM significantly decreases the fiber diameter. Raman spectra confirm the effective loading of TAM in the resulting electrospun fibers. The drug release behavior of RSF/2-HP-beta-CD/TAM composite fibers indicates that the TAM loaded in such a composite fibers is able to perform a sustainable release. Thus, the TAM-loaded RSF electrospun fibers presented in this report may have a great potential as be a promising local drug delivery system for breast cancer therapy. (C) 2016 Elsevier B.V. All rights reserved.
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