Assay of iodine monochloride via iodination of 2-chloroaniline using reversed-phase liquid chromatography

Summary: A sulfated polyborate catalyst has been developed for efficient iodination of arenes with high regioselectivity and yield. This method is versatile for mono and diiodination of various substrates, including the synthesis of intermediates for thyroid treatment drugs and specialty chemicals.

Summary: The in situ iodine monochloride (I-Cl) generation followed by iodination of aromatics using NCBSI/KI system is efficient for mono- and diiodination of a wide range of moderate to highly activated arenes, with good yield and purity. Moreover, the precursor N-(benzenesulfonyl)benzenesulfonamide can be recovered and transformed to NCBSI, making the protocol eco-friendly and cost-effective.