Cyclic Sulfoxides-Garlicnins K1, K2, and H1-Extracted from Allium sativum

Newly identified cyclic sulfoxides-garlicnins K-1 (1), K-2 (2), and H-1 (3)-were isolated from the acetone extracts of the bulbs of garlic, Allium sativum. Garlicnin Hi (3) demonstrated potential to suppress tumor cell proliferation by regulating macrophage activation. The structures of garlicnins K-1 and K-2, 3,4-dimethyl-5-allyl-tetrahydrothiophen-2-one-S-oxides, and the structure of garlicnin H-1, 3-carboxy-3-hydroxy-4-methyl-5-allylsulfoxide-tetrahydrothiophen-2-(ethane-1,2-diol)-S-oxide were characterized by spectroscopic analysis.