期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 63, 期 11, 页码 955-960出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c15-00504
关键词
Juniperus chinensis; Cupressaceae; 9 '-methoxycalocedrin; alpha-methyl artoflavanocoumarin; 5,7,4 '-trihydroxy-2-styrylchromone; beta-site amyloid precursor protein cleaving enzyme 1 (BACE1)
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2012R1A6A1028677]
Two new compounds (2, 3) and 20 known compounds (1, 4-22) were isolated from the heartwood of Juniperus chinensis LINNE (Cupressaceae), and their structures were elucidated as 9'-methoxycalocedrin (1); a-methyl artoflavanocoumarin (2); 5,7,4'-trihydroxy-2-styrylchromone (3); cedrol (4); widdrol (5); savinin (6); calocedrin (7); 10-oxowiddrol (8); 12-hydroxywiddrol (9); (+)-naringenin (10); vanillic acid methyl ester (11); (+)-taxifolin (12); (+)-aromadendrin (13); kaempferol (14); quercetin (15); (7S,8R)-dihydro-3'-hydroxy-8-hydroxymethyl-7-(4-hydroxy-3-methoxyphenyl)-1'-benzofuranpropanol (16); styraxlignolide C (17); protocatechuic acid (18); vanillic acid (19); (7R,8S)-dihydro-3'-methoxy-8-hydroxymethyl-7-(4-hydroxy-3-methoxyphenyl)-1'-benzofuranpropanol 4-O-beta-D-glucopyranoside (20); (7S,8S)-dihydro-3'-hydroxy-8-hydroxymethyl-7-(4-hydroxy-3-methoxyphenyl)-1'-benzofuranpropanol 4-O-alpha-L-rhamnopyranoside (21); and (+)-catechin (22) on the basis of spectroscopic evidence. The new compounds (2, 3) exhibited good inhibitory activities against beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), with IC50 values of 6.25, and 11.91 mu m, respectively.
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