期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 63, 期 12, 页码 992-997出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c15-00497
关键词
polysaccharide; hydroxyethylcellulose; polymeric prodrug; mechanochemical solid-state copolymerization; drug release; 5-fluorouracil
Novel polymeric prodrugs were synthesized by mechanochemical solid-state copolymerization of hydroxyethylcellulose and the methacryloyloxy derivative of 5-fluorouracil (5-FU). Copolymerization was about 94% complete after 4h, and the polymeric prodrug was quantitatively obtained after 14h of reaction. The number average molecular weight (M-n) and polydispersity (H) of the polymeric prodrug were 39000 g/mol and 6.20, respectively. Mechanical fracturing of the polymer in a stainless steel twin-shell blender improved these properties (M-n=16000 g/mol and H=1.94). 5-FU was sustainably released from the polymeric prodrugs, and the rate was not affected by the molecular weight or molecular weight distribution of the prodrug under the experimental conditions used. These results suggest that novel polymeric prodrugs composed of a polysaccharide and a synthetic polymer can be fabricated by mechanochemical solid-state copolymerization under anaerobic conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据