Bioavailability of nanoenulsions modified with curcumin and cerium dioxide nanopar-ticles

In this work, the physicochemical properties and biological activity of nanoemulsions prepared from paraffin oil and stabilized by nonionic surfactants as carriers of curcumin and cerium dioxide nanoparticles were studied. An analysis of the results showed that curcumin was incorporated into the oil droplets while cerium dioxide nanoparticles were adsorbed on the surface of oil droplets. The nanoemulsion droplet size did not exceed 100 nm. The absence of toxicity to mouse embryonic fibroblasts in vitro and after a single intraperi-toneal injection to mice in vivo makes the nanoemulsions promising drug carriers for advanced biomedical applications.

Automated summary

This work investigated the physicochemical properties and biological activity of nanoemulsions prepared from paraffin oil and stabilized by nonionic surfactants as carriers of curcumin and cerium dioxide nanoparticles. The results showed that curcumin was incorporated into the oil droplets while cerium dioxide nanoparticles were adsorbed on the surface of oil droplets. The nanoemulsion droplet size did not exceed 100 nm. The nanoemulsions demonstrated no toxicity to mouse embryonic fibroblasts in vitro and after a single intraperitoneal injection to mice in vivo, indicating their potential as drug carriers for advanced biomedical applications.