Pharmacokinetic study about compatibility of Eucommia ulmoides and Psoralea corylifolia

Objective: The compatibility of Eucommia ulmoides (Eu) and Psoralea corylifolia (Pc) on the pharmacoki-netic (PK) properties in the rat was explored in this study.Methods: Eu extract, Pc extract and the combined extracts (crude drug ratio was 2:1) was administered by gavage, respectively. Two PK experiments were conducted. In first one, the blood samples were col-lected via the occuli chorioideae vein to get the PK properties of the components. In second one, the blood samples were simultaneously collected via the internal jugular vein or portal vein at different time points and the concentrations of target ingredients were detected by LC/MS/MS to clear the location where the interaction of Eu and Pc took place in vivo.Results: Eight of 11 ingredients in Eu and Pc extract were determined in rat plasma. The exposure levels of geniposidic acid (GPA), aucubin (AU), geniposide (GP), pinoresinol diglucoside (PDG), psoralen glyco-sides (PLG) and isopsoralen glycosides (IPLG) were decreased 1/5-2/3 after administration of combined extracts. Comparing to the combined administration, the exposure of GPA and AU in plasma of single Eu administration collected via the portal vein were decreased 1/3-2/3, and the values of AUC0-24h and AUC0-1 of GP collected from the portal vein or internal jugular vein were double increased. The other components' parameters were not significantly changed.Conclusion: In summary, the Pc and Eu combined administration could affect the exposure of the main components of Eu extract in rats due to the changed intestinal absorption. The research on the compat-ibility of Pc and Eu was helpful to guide the clinical administration of Eu and Pc simultaneously.(c) 2022 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Automated summary

The study investigated the pharmacokinetic properties of Eucommia ulmoides and Psoralea corylifolia in rats. It was found that the combined administration of the two herbs could affect the exposure of the main components of Eucommia ulmoides extract in rats due to altered intestinal absorption. This research provides guidance for the simultaneous clinical administration of Eucommia ulmoides and Psoralea corylifolia.