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Untangling the Role of Tau in Huntington's Disease Pathology

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Summary: Tau protein is associated with neurodegenerative diseases. The presence of hyperphosphorylated tau has been found in the brains of Huntington's disease (HD) patients. However, the role of tau in the development of HD is not well understood. This study investigates the impact of tau expression and knockout in an HD mouse model and finds that tau expression or ablation does not affect the progression of HD symptoms.

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Inhibition of GSK-3 ameliorates the pathogenesis of Huntington?s disease

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Summary: The inhibition of GSK-3 reduces the toxicity of mHtt and improves HD symptoms by reducing mHtt aggregates in the striatum, increasing levels of autophagic and lysosomal markers. The treatment with L807mts also lowers hyperglycemia and enhances motor-coordination functions in R6/2 mouse model of HD. Additionally, L807mts restores the expression levels of critical neuroprotective factors in the HD striatum, providing neurotrophic support and improving HD symptoms.

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Selected CSF biomarkers indicate no evidence of early neuroinflammation in Huntington disease

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Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease

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Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

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