Bacillus subtilis application on decolonisation of Staphylococcus aureus

Summary: Conventional antibiotics and topical strategies have limited success in reducing Staphylococcus aureus infection rates. However, the use of the probiotic Bacillus subtilis can effectively control colonisation in the intestine and nose. This probiotic strategy offers several advantages and is suitable for patients at long-term risk of S aureus infection.

Summary: The safety and tolerability of the unique strain Bacillus subtilis MB40 was assessed through in silico, in vitro, and in vivo studies. The study confirmed the absence of undesirable genetic elements encoding toxins and antibiotic resistance, and found that MB40 was well tolerated in both rats and healthy human volunteers. Based on the research, it was concluded that Bacillus subtilis MB40 does not pose any human health concerns under the tested conditions.