期刊
MARINE DRUGS
卷 14, 期 6, 页码 -出版社
MDPI AG
DOI: 10.3390/md14060111
关键词
soft coral; Lobophytum crassum; cembrane-based diterpenes; NO inhibition
资金
- NSFC [21202123]
- ZJNSF [LQ12B02002]
- CSC [201408330121]
- Wenzhou Medical University [QTJ10018]
- NIH, National Cancer Institute, Center for Cancer Research
Ten new cembrane-based diterpenes, locrassumins A-G (1-7), (-)-laevigatol B (8), (-)-isosarcophine (9), and (-)-7R, 8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11-18). The structures of the new compounds were determined by extensive spectroscopic analysis and by comparison with previously reported data. Locrassumin C (3) possesses an unprecedented tetradecahydrobenzo[3,4]cyclobuta[1,2][8]annulene ring system. Compounds 1, 7, 12, 13, and 17 exhibited moderate inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 8-24 mu M.
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