期刊
MARINE DRUGS
卷 14, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/md14060118
关键词
marine organisms; pelorol; total synthesis; PI3K inhibitor; anti-tumor activity
资金
- National High-tech R&D Program of China (863 Program) [2013AA092903]
- Guangdong Province Natural Science Foundation [2015A030313184]
There are numerous biologically active substances with novel structures and unique physiological functions in marine organisms. These substances are important sources of new lead compounds. Pelorol is a natural product isolated from marine organisms that possesses a novel structure with high bioactivity. In this paper, the synthesis of pelorol has been completed, and the synthesis of some intermediates has been optimized and scaled up. Five pelorol analogs have also been prepared. Preliminary biological activity testing demonstrated that compounds 5 and 6 might be potential lead compounds for cancer therapy.
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