期刊
MARINE DRUGS
卷 14, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/md14120224
关键词
keratan sulfate; gut microbiota; modulation; Lactobacillus spp; shark cartilage
资金
- National Natural Science Foundation of China [31670811]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1406402]
- National Science & Technology Support Program of China [2013BAB01B02]
- Qingdao National Laboratory for Marine Science and Technology [2015ASKJ02]
- Taishan scholar project special funds
- Major science and technology projects in Shandong Province [2015ZDJS04002]
Keratan sulfate (KS) represents an important family of glycosaminoglycans that are critical in diverse physiological processes. Recently, accumulating evidence has provided a wealth of information on the bioactivity of KS, which established it as an attractive candidate for drug development. However, although KS has been widely explored, less attention has been given to its effect on gut microbiota. Therefore, given that gut microbiota plays a pivotal role in health homeostasis and disease pathogenesis, we investigated here in detail the effect of KS on gut microbiota by high-throughput sequencing. As revealed by heatmap and principal component analysis, the mice gut microbiota was readily altered at different taxonomic levels by intake of low (8 mg/kg) and high dosage (40 mg/kg) of KS. Interestingly, KS exerted a differing effect on male and female microbiota. Specifically, KS induced a much more drastic increase in the abundance of Lactobacillus spp. in female (sixteen-fold) versus male mice (two-fold). In addition, combined with alterations in gut microbiota, KS also significantly reduced body weight while maintaining normal gut homeostasis. Altogether, we first demonstrated a sex-dependent effect of KS on gut microbiota and highlighted that it may be used as a novel prebiotic for disease management.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据