期刊
MARINE DRUGS
卷 14, 期 10, 页码 -出版社
MDPI AG
DOI: 10.3390/md14100180
关键词
soft coral; Umbellulifera petasites; steroid; cytotoxic activity; anti-inflammatory activity
资金
- Ministry of Science and Technology [MOST 102-2628-B-110-002-MY2, 104-2320-B-110-001-MY2]
- NSYSU-KMU Joint Research Project of Taiwan [NSYSUKMU 105-I008]
- Taiwan Protein Project (MOST) [105-0210-01-12-01]
Three new steroids, petasitosterones A and B (1 and 2) and a spirosteroid petasitosterone C (3), along with eight known steroids (4-11), were isolated from a Formosan marine soft coral Umbellulifera petasites. The structures of these compounds were elucidated by extensive spectroscopic analysis and comparison of spectroscopic data with those reported. Compound 3 is a marine steroid with a rarely found A/B spiro[4,5]decane ring system. Compounds 1-3 and 5 displayed inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 2 and 5 exhibited significant anti-inflammatory activity to inhibit nitric oxide (NO) production. The inhibitory activities for superoxide anion generation and elastase release of compounds 1-11 were also examined to evaluate the anti-inflammatory potential, and 2-4 were shown to exhibit significant activities.
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