Surgical treatment of hepatocellular carcinoma after Fontan operation: three case reports and review of the literature

Article Gastroenterology & Hepatology

The absence of warfarin treatment and situs inversus are associated with the occurrence of hepatocellular carcinoma after Fontan surgery

Ryotaro Sakamori et al.

Summary: This study found that warfarin absence and situs inversus are associated with the development of HCC after Fontan procedure. Warfarin absence and situs inversus are potential risk factors for HCC occurrence.

JOURNAL OF GASTROENTEROLOGY (2022)

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Article Multidisciplinary Sciences

Risk factors for Fontan-associated hepatocellular carcinoma

Tomomi Kogiso et al.

Summary: This study found that the complication of polysplenia and a higher MELD-XI score may be independent risk factors for the development of hepatocellular carcinoma (HCC) in patients with Fontan-associated liver disease (FALD), and patients with these risk factors tend to have a poor prognosis.

PLOS ONE (2022)

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Article Cardiac & Cardiovascular Systems

Hepatocellular carcinoma and the Fontan circulation: Clinical presentation and outcomes

Mathias Possner et al.

Summary: Hepatocellular carcinoma (HCC) in Fontan patients occurs at a young age with many patients being asymptomatic at diagnosis. 65% of the tumors are located in the right hepatic lobe. 48% of patients died during a median follow-up duration.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Incidence, Predictors, and Mortality in Patients With Liver Cancer After Fontan Operation

Hideo Ohuchi et al.

Summary: The study evaluated the incidence and prognosis of LC after Fontan operation, revealing a rapid increase in LC incidence ≥ 30 years post-operation. Liver fibrosis indices and AFP were predictive of new-onset LC, emphasizing the importance of close monitoring for early detection and better prognosis.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Article Surgery

Laparoscopic partial liver resection for hepatocellular carcinoma arising from Fontan-associated liver disease: a case report

Miku Iwata et al.

Summary: The Fontan procedure is a palliative surgery for functional single ventricle, often leading to chronic congestive liver. Increasing cases of hepatocellular carcinoma (HCC) arising from liver fibrosis and cirrhosis post-Fontan procedure have been reported. This case study describes a successful laparoscopic partial liver resection for a 31-year-old male patient with HCC after FP, leading to a disease-free outcome after 7 months of follow-up.

SURGICAL CASE REPORTS (2021)

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Article Gastroenterology & Hepatology